Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS17506  |
| T6SS type | Type i1 |
| Strain | Aliivibrio fischeri strain ES401 |
| Replicon (RefSeq) | chromosome (NZ_SRJG01000005) |
| Location | 345059..392876 |
| Function | anti-bacterial |
| Comment | Although the T6SS did not confer a competitive advantage for V. fischeri strain ES401 under planktonic conditions, a combination of both host-like pH and viscosity was necessary for T6SS competition. For ES401, high viscosity activates T6SS expression and neutral/acidic pH promotes cell-cell contact for killing, and this pH-dependent phenotype was conserved in the majority of T6SS-encoding strains examined. |
| References | [1] Speare L, Woo M, Bultman KM, Mandel MJ, Wollenberg MS, Septer AN. et al (2021) Host-Like Conditions Are Required for T6SS-Mediated Competition among Vibrio fischeri Light Organ Symbionts.. mSphere. 6(4):e0128820. [PudMed:34287008] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VFES401_RS15675 | 340423..342714 | - | 2292 | WP_167816890.1 | patatin-like phospholipase family protein | ||
| VFES401_RS15680 | 342985..343587 | + | 603 | WP_063646018.1 | hypothetical protein | ||
| VFES401_RS15685 (tagH) | 343597..345057 | + | 1461 | WP_135354009.1 | type VI secretion system-associated FHA domain protein TagH | ||
| T6CP259573 | TssJ | VFES401_RS15690 (tssJ) | 345059..345559 | + | 501 | WP_012535132.1 | type VI secretion system lipoprotein TssJ |
| T6CP259574 | TssK | VFES401_RS15695 (tssK) | 345571..346896 | + | 1326 | WP_063658833.1 | type VI secretion system baseplate subunit TssK |
| T6CP259575 | TssL | VFES401_RS15700 (icmH) | 346893..347684 | + | 792 | WP_012534924.1 | type IVB secretion system protein IcmH/DotU |
| VFES401_RS15705 | 347725..349182 | + | 1458 | WP_135354010.1 | DUF4150 domain-containing protein | ||
| VFES401_RS15710 | 350767..351378 | + | 612 | WP_081251060.1 | glycoside hydrolase family 19 protein | ||
| VFES401_RS15715 | 351371..352171 | + | 801 | WP_063658827.1 | hypothetical protein | ||
| T6CP259576 | TssL | VFES401_RS15720 (icmH) | 352287..352976 | + | 690 | WP_081251043.1 | type IVB secretion system protein IcmH/DotU |
| VFES401_RS15725 | 353016..354515 | + | 1500 | WP_063658823.1 | DUF4150 domain-containing protein | ||
| VFES401_RS15730 | 354528..355268 | + | 741 | WP_063658821.1 | AHH domain-containing protein | ||
| VFES401_RS15735 | 355279..355851 | + | 573 | WP_063644920.1 | hypothetical protein | ||
| VFES401_RS15740 | 355863..356354 | + | 492 | WP_063658819.1 | hypothetical protein | ||
| VFES401_RS15745 | 356563..356991 | + | 429 | WP_135354011.1 | hypothetical protein | ||
| VFES401_RS15750 | 357081..367673 | - | 10593 | WP_135354012.1 | tandem large repeat | ||
| VFES401_RS15755 | 367921..368850 | + | 930 | WP_063645629.1 | peptidoglycan DD-metalloendopeptidase family protein | ||
| T6CP259577 | TssA | VFES401_RS15760 | 369086..370393 | + | 1308 | WP_063659069.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP259578 | TssM | VFES401_RS15765 (tssM) | 370428..373826 | + | 3399 | WP_063658813.1 | type VI secretion system membrane subunit TssM |
| VFES401_RS15770 | 373862..374311 | + | 450 | WP_012535053.1 | Lrp/AsnC family transcriptional regulator | ||
| T6CP259579 | TssG | VFES401_RS15775 (tssG) | 374383..375381 | - | 999 | WP_063647519.1 | type VI secretion system baseplate subunit TssG |
| T6CP259580 | TssF | VFES401_RS15780 (tssF) | 375378..377126 | - | 1749 | WP_135354013.1 | type VI secretion system baseplate subunit TssF |
| T6CP259581 | TssE | VFES401_RS15785 (tssE) | 377139..377549 | - | 411 | WP_063645633.1 | type VI secretion system baseplate subunit TssE |
| T6CP259582 | TssC | VFES401_RS15790 (tssC) | 377609..379087 | - | 1479 | WP_063645634.1 | type VI secretion system contractile sheath large subunit |
| T6CP259583 | TssB | VFES401_RS15795 (tssB) | 379096..379605 | - | 510 | WP_012535409.1 | type VI secretion system contractile sheath small subunit |
| T6CP259584 | TssA | VFES401_RS15800 (tssA) | 379664..381223 | - | 1560 | WP_135354014.1 | type VI secretion system protein TssA |
| VFES401_RS15805 | 381225..383210 | - | 1986 | WP_135354015.1 | protein kinase | ||
| VFES401_RS15810 | 383364..384305 | - | 942 | WP_063645637.1 | hypothetical protein | ||
| VFES401_RS15815 | 384305..385282 | - | 978 | WP_063645638.1 | DUF2169 domain-containing protein | ||
| VFES401_RS15820 | 385263..386588 | - | 1326 | WP_135354016.1 | hypothetical protein | ||
| VFES401_RS15825 | 386597..387091 | - | 495 | WP_135354017.1 | hypothetical protein | ||
| T6CP259585 | TssI | VFES401_RS15830 (vgrG) | 387078..389156 | - | 2079 | WP_135354018.1 | type VI secretion system tip protein VgrG |
| T6CP259586 | TssD | VFES401_RS15835 | 389226..389744 | - | 519 | WP_012533499.1 | Hcp family type VI secretion system effector |
| T6CP259587 | TssH | VFES401_RS15840 (tssH) | 390210..392876 | + | 2667 | WP_135354019.1 | type VI secretion system ATPase TssH |
| VFES401_RS15845 | 392863..394467 | + | 1605 | WP_063645642.1 | sigma-54-dependent Fis family transcriptional regulator | ||
| VFES401_RS15850 | 394468..394968 | + | 501 | WP_063658802.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0371 |
VFES401_RS15770 (tasR) | protein | Unknown | Aliivibrio fischeri strain ES401 | chromosome (NZ_SRJG01000005) | 373862..374311 (+) | WP_012535053.1 | hcp promotor (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|