Detailed information of regulator
Summary
| Regulator ID | REG0289  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | c-di-GMP regulatory pathway |
| KEGG pathway (determined by BlastKOALA) | - |
| Related T6SS | T6SS00002 (Type i1) |
| Strain | Vibrio cholerae O1 biovar El Tor str. N16961 |
| Replicon | chromosome |
| Sequence | Protein sequence (71 a.a.); Nucleotide sequence (213 bp) |
| Description | cspV affects the level of c-di-GMP, possibly through upregulation of the phosphodiesterase gene rocS.And ΔcspV strain exhibited a significant decrease in T6SS-mediated killing of E. coli, comparable to that of the Δhcp mutant, at 37°C and 25°C, while no killing was observed at 15°C in any of the strains. |
| Reference |
External database links
| Locus tag (Gene) | VCA0933 (CspV) |
| Coordinates (Strand) | 886068..886280 (+) |
| NCBI ID | 446027150 |
| RefSeq | NC_002506 |
| Uniprot ID | CSPV_VIBCH, A0A0X1L0T7_VIBCO, A0A0H3AEQ6_VIBC3, D7HBL1_VIBCL, A0A0K9UW31_VIBCL, A0A0H3Q5W6_VIBCL, C3LWJ7_VIBCM, A0A085QG16_VIBCL |
| KEGG ID | vcx:VAA049_2057, vcq:EN18_02945, vcz:VAB027_1189, vco:VC0395_0306, vcm:VCM66_A0893, vch:VCA0933 |
| KEGG pathway (determined by BlastKOALA) | - |
| PDB ID | - |
Target
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Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| Unknown | ↓ | - |
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Pfam domain hit(s) of regulator
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Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| CSD | PF00313.24 | 3.3e-29 | 5..69 |
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Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
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Prediction | Region | Sequence |
|---|---|---|
| Inside | 1-70 | MSTKMTGSVKWFNETKGFGFLTQDNGGNDVFVHFNSIQSEGFKTLAEGQRVSFIVEQGKKGPQASNVVAL |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.9881 | - | - |
Protein sequence of regulator: 71 a.a. .
>REG0289 NC_002506:886068-886280 [Vibrio cholerae O1 biovar El Tor str. N16961]
MSTKMTGSVKWFNETKGFGFLTQDNGGNDVFVHFNSIQSEGFKTLAEGQRVSFIVEQGKKGPQASNVVAL*
MSTKMTGSVKWFNETKGFGFLTQDNGGNDVFVHFNSIQSEGFKTLAEGQRVSFIVEQGKKGPQASNVVAL*
Nucleotide sequence of regulator: 213 bp .
>REG0289 NC_002506:886068-886280 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGTCTACTAAAATGACTGGTTCTGTAAAATGGTTCAACGAAACTAAAGGTTTCGGTTTTCTTACTCAAGACAACGGTGG
CAACGATGTGTTTGTTCACTTTAATTCTATTCAGTCAGAAGGTTTCAAAACCTTAGCTGAAGGTCAACGTGTTAGCTTTA
TCGTTGAACAAGGTAAGAAAGGCCCTCAAGCGTCTAACGTAGTCGCACTGTAA
ATGTCTACTAAAATGACTGGTTCTGTAAAATGGTTCAACGAAACTAAAGGTTTCGGTTTTCTTACTCAAGACAACGGTGG
CAACGATGTGTTTGTTCACTTTAATTCTATTCAGTCAGAAGGTTTCAAAACCTTAGCTGAAGGTCAACGTGTTAGCTTTA
TCGTTGAACAAGGTAAGAAAGGCCCTCAAGCGTCTAACGTAGTCGCACTGTAA