Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01006  |
| T6SS type | Type i4b |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (GenBank) | chromosome I (CP009538) |
| Location | 2062195..2082181 |
| Function | - |
| Comment | The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection. |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagF | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AQ15_1806 | 2057657..2058490 | - | 834 | 772960263 | integrase core domain protein | ||
| AQ15_1807 | 2058514..2058777 | - | 264 | 772959349 | transposase family protein | ||
| AQ15_1808 | 2059060..2060130 | - | 1071 | 772962104 | helix-turn-helix family protein | ||
| AQ15_1809 | 2060137..2060865 | - | 729 | 772961109 | hypothetical protein | ||
| AQ15_1810 | 2061372..2061710 | + | 339 | 772961230 | hypothetical protein | ||
| T6CP259666 | TssL | AQ15_1811 | 2062195..2062980 | - | 786 | 772961401 | type IV/VI secretion system, DotU family domain protein |
| T6CP259665 | TssK | AQ15_1812 | 2062977..2064323 | - | 1347 | 772962531 | hypothetical protein |
| T6CP259664 | TssJ | AQ15_1813 | 2064432..2065046 | - | 615 | 772961283 | type VI secretion lipofamily protein |
| AQ15_1814 | 2065421..2066092 | + | 672 | 772960562 | tetratricopeptide repeat family protein | ||
| T6CP259663 | TssB | AQ15_1815 | 2066129..2066647 | + | 519 | 772959868 | hypothetical protein |
| T6CP259662 | TssC | AQ15_1816 | 2066664..2068154 | + | 1491 | 772959296 | hypothetical protein |
| T6CP259661 | TssD | AQ15_1817 | 2068227..2068730 | + | 504 | 772959419 | type VI secretion system effector, Hcp1 family protein |
| T6CP259660 | TssE | AQ15_1818 | 2068788..2069270 | + | 483 | 772960468 | 25-like lysozyme family protein |
| T6CP259659 | TssF | AQ15_1819 | 2069350..2071188 | + | 1839 | 772962258 | hypothetical protein |
| T6CP259658 | TssG | AQ15_1820 | 2071152..2072252 | + | 1101 | 772962007 | hypothetical protein |
| T6CP259657 | TssH | AQ15_1821 (clpV) | 2072286..2074955 | + | 2670 | 772962497 | type VI secretion ATPase, ClpV1 family |
| T6CP259656 | TssA | AQ15_1822 | 2075045..2076166 | + | 1122 | 772961378 | hypothetical protein |
| AQ15_1823 | 2076365..2077297 | - | 933 | 772960690 | ompA family protein | ||
| T6CP259655 | TagF | AQ15_1824 | 2077302..2078291 | - | 990 | 772959816 | hypothetical protein |
| T6CP259654 | TssM | AQ15_1825 | 2078288..2082181 | - | 3894 | 772960163 | intracellular multiplication and macrophage-killing family protein |
| AQ15_1826 | 2082460..2082987 | - | 528 | 772959383 | D-alanyl-D-alanine carboxypeptidase family protein | ||
| AQ15_1827 | 2083437..2084423 | + | 987 | 772962611 | hypothetical protein | ||
| AQ15_1828 | 2084633..2086081 | - | 1449 | 772959401 | outer membrane efflux family protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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