Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS01006 experimental
T6SS type Type i4b
Strain Burkholderia pseudomallei K96243
Replicon (GenBank) chromosome I (CP009538)
Location 2062195..2082181
Function -
Comment The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection.
References
[1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTagFTssATssBTssCTssDTssETssFTssGTssHTssJTssKTssLTssM
Number1111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
AQ15_1806 2057657..2058490 - 834 772960263 integrase core domain protein
AQ15_1807 2058514..2058777 - 264 772959349 transposase family protein
AQ15_1808 2059060..2060130 - 1071 772962104 helix-turn-helix family protein
AQ15_1809 2060137..2060865 - 729 772961109 hypothetical protein
AQ15_1810 2061372..2061710 + 339 772961230 hypothetical protein
T6CP259666 TssL AQ15_1811 2062195..2062980 - 786 772961401 type IV/VI secretion system, DotU family domain protein
T6CP259665 TssK AQ15_1812 2062977..2064323 - 1347 772962531 hypothetical protein
T6CP259664 TssJ AQ15_1813 2064432..2065046 - 615 772961283 type VI secretion lipofamily protein
AQ15_1814 2065421..2066092 + 672 772960562 tetratricopeptide repeat family protein
T6CP259663 TssB AQ15_1815 2066129..2066647 + 519 772959868 hypothetical protein
T6CP259662 TssC AQ15_1816 2066664..2068154 + 1491 772959296 hypothetical protein
T6CP259661 TssD AQ15_1817 2068227..2068730 + 504 772959419 type VI secretion system effector, Hcp1 family protein
T6CP259660 TssE AQ15_1818 2068788..2069270 + 483 772960468 25-like lysozyme family protein
T6CP259659 TssF AQ15_1819 2069350..2071188 + 1839 772962258 hypothetical protein
T6CP259658 TssG AQ15_1820 2071152..2072252 + 1101 772962007 hypothetical protein
T6CP259657 TssH AQ15_1821 (clpV) 2072286..2074955 + 2670 772962497 type VI secretion ATPase, ClpV1 family
T6CP259656 TssA AQ15_1822 2075045..2076166 + 1122 772961378 hypothetical protein
AQ15_1823 2076365..2077297 - 933 772960690 ompA family protein
T6CP259655 TagF AQ15_1824 2077302..2078291 - 990 772959816 hypothetical protein
T6CP259654 TssM AQ15_1825 2078288..2082181 - 3894 772960163 intracellular multiplication and macrophage-killing family protein
AQ15_1826 2082460..2082987 - 528 772959383 D-alanyl-D-alanine carboxypeptidase family protein
AQ15_1827 2083437..2084423 + 987 772962611 hypothetical protein
AQ15_1828 2084633..2086081 - 1449 772959401 outer membrane efflux family protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector