Detailed information of effector


Summary

Effector ID EFF01495 experimental
Effector type Tre
Cognate immunity protein IMU00317 experimental; IMU00330 experimental; IMU00331 experimental; IMU00332 experimental
Related T6SS (Type) T6SS00234 insolico (Type i3)
Strain Serratia proteamaculans 568
Replicon chromosome
Sequence Protein sequence (445 a.a.); Nucleotide sequence (1335 bp)
Description Tre1 (type VI secretion ADP-ribosyltransferase effector 1), contains an N-terminal PAAR domain,h the toxicity of Tre1 deriving from its ART-like domain.
Reference
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
External database links

Locus tag (Gene) Spro_3017 (Tre1)
Coordinates (Strand) 3321185..3322519 (+)
NCBI ID 157371257
RefSeq NC_009832
Uniprot ID UPI0000E791AD
KEGG ID -
PDB ID -
Pfam domain hit(s)

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Domain
Pfam ID
E-value
Aligned region
ARTPF01129.201.3e-15274..441
PAAR_motifPF05488.153.3e-1472..140
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Inside1-19MSELSAARELDEIAHTASE
Transmembrane helix20-39GWMIAGLIGGAIVGAALIAV
Outside40-43TGGT
Transmembrane helix44-66AAVAVAAVVAGASAGGGLGEVLG
Inside67-178SMSWAPRHVTGVLADGSPNVYINGRPAIRAHISTGECSEDGPAKKVVAQGSAKVYINDFPAARINDLLACSAEIHTGSPNVIIGGEKEQTDDIEPEIPDWVNWTLLAAGAGA
Transmembrane helix179-201AAVLATPAIAILGTLGGLGGGFA
Outside202-444GSLIGGAFFGEGSDGQKWSMLAGGFVGGFAGGKGGAKFDAWRNTKIVEPPPRVTTKVDPISPPRMTLAEAVGQEQAKVWTQTARANAEKNNAQLSTLLTDDQIGAIYGYTTNEGYTALNPALRGQTPLTPELEAFTGHVTDGLNKLPAYNGETYRGTTLPAHILEQNQIGGTVSDGGFMSTSAKTPFDGDVSISVRGNSGKQIDFLSKYKNEAEVLYPPNTRFEVINRIEQNGTTHLLYREIP


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.8037--


  Protein sequence: 445 a.a.    .

>EFF01495 NC_009832:3321185-3322519 Type VI ADP-Ribosyltransferase Effector (Tre) [Serratia proteamaculans 568]
MSELSAARELDEIAHTASEGWMIAGLIGGAIVGAALIAVTGGTAAVAVAAVVAGASAGGGLGEVLGSMSWAPRHVTGVLA
DGSPNVYINGRPAIRAHISTGECSEDGPAKKVVAQGSAKVYINDFPAARINDLLACSAEIHTGSPNVIIGGEKEQTDDIE
PEIPDWVNWTLLAAGAGAAAVLATPAIAILGTLGGLGGGFAGSLIGGAFFGEGSDGQKWSMLAGGFVGGFAGGKGGAKFD
AWRNTKIVEPPPRVTTKVDPISPPRMTLAEAVGQEQAKVWTQTARANAEKNNAQLSTLLTDDQIGAIYGYTTNEGYTALN
PALRGQTPLTPELEAFTGHVTDGLNKLPAYNGETYRGTTLPAHILEQNQIGGTVSDGGFMSTSAKTPFDGDVSISVRGNS
GKQIDFLSKYKNEAEVLYPPNTRFEVINRIEQNGTTHLLYREIP*

  Nucleotide sequence: 1335 bp    .

>EFF01495 NC_009832:3321185-3322519 Type VI ADP-Ribosyltransferase Effector (Tre) [Serratia proteamaculans 568]
ATGAGTGAGCTTAGTGCAGCGCGCGAGTTGGATGAAATAGCCCACACTGCGTCCGAAGGCTGGATGATCGCCGGTTTGAT
TGGCGGCGCGATTGTCGGTGCCGCACTAATCGCCGTTACTGGTGGCACGGCGGCGGTCGCTGTCGCAGCCGTAGTTGCAG
GCGCTTCTGCCGGAGGCGGGCTTGGTGAAGTGCTGGGCAGCATGTCCTGGGCACCTCGCCATGTCACCGGGGTACTTGCC
GATGGCTCGCCGAATGTCTACATCAATGGTAGACCTGCCATACGCGCGCATATCTCAACAGGAGAATGCAGTGAAGATGG
CCCGGCCAAAAAGGTCGTTGCTCAAGGCTCAGCCAAAGTCTATATCAATGATTTCCCTGCGGCCCGTATCAATGATTTGC
TGGCATGTAGCGCCGAAATTCACACCGGTTCACCTAACGTCATTATTGGCGGAGAAAAAGAGCAAACGGATGATATTGAA
CCAGAGATCCCCGACTGGGTGAACTGGACGCTGCTTGCGGCGGGTGCCGGTGCCGCTGCCGTGCTCGCCACCCCTGCCAT
AGCGATACTGGGTACGCTGGGCGGATTGGGAGGCGGTTTCGCAGGCAGTTTAATTGGCGGGGCTTTCTTCGGTGAAGGCA
GTGATGGTCAGAAATGGTCAATGCTGGCGGGAGGATTCGTCGGCGGATTTGCCGGTGGCAAAGGCGGTGCCAAGTTTGAT
GCTTGGCGTAATACGAAAATCGTCGAACCTCCACCTCGGGTCACTACAAAAGTAGACCCCATTTCTCCGCCCCGTATGAC
TCTGGCAGAGGCTGTAGGCCAAGAACAAGCGAAGGTGTGGACACAAACGGCAAGGGCCAATGCTGAAAAGAATAACGCTC
AGTTGTCAACCTTGCTCACTGATGACCAAATAGGCGCCATTTACGGTTATACGACTAATGAAGGCTACACAGCATTAAAT
CCAGCATTACGAGGACAAACACCATTGACTCCAGAACTTGAGGCTTTTACTGGACATGTAACTGATGGGCTCAATAAGTT
GCCTGCTTACAACGGGGAGACATATCGCGGAACGACATTACCAGCACATATTTTGGAACAAAATCAGATTGGCGGCACCG
TTTCAGATGGCGGTTTCATGAGTACGTCGGCAAAAACTCCTTTTGACGGTGACGTTAGCATCTCGGTACGAGGAAACTCA
GGTAAACAAATTGACTTTTTGTCAAAGTATAAAAACGAAGCAGAGGTTCTATATCCTCCGAATACTCGGTTTGAAGTTAT
TAATCGCATAGAGCAAAATGGCACAACACATCTTTTATACAGGGAAATTCCATGA