Detailed information of accessory protein


Summary

Accessory protein ID ACP00044 experimental
Type chaperone
Related T6SS (Type) T6SS00004 (Type i1)
Strain Pseudomonas aeruginosa PAO1
Replicon chromosome
Related structure protein -
Related effector PA1863 (ModA)
Description ModA binds to molybdate in the periplasm and ModBC harbors two integral membrane permeases.
Reference [1] Wang T, Du X, Ji L, et al. Pseudomonas aeruginosa T6SS-mediated molybdate transport contributes to bacterial competition during anaerobiosis. Cell Rep. 2021 Apr 13;35(2):108957. doi: 10.1016/j.celrep.2021.108957. PMID: 33852869; [2] Pederick VG, Eijkelkamp BA, Ween MP, et al. Acquisition and role of molybdate in Pseudomonas aeruginosa. Appl Environ Microbiol. 2014 Nov;80(21):6843-52. doi: 10.1128/AEM.02465-14. Epub 2014 Aug 29. PMID: 25172858; [3] Périnet S, Jeukens J, Kukavica-Ibrulj I, et al. Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection. BMC Res Notes. 2016 Jan 12;9:23. doi: 10.1186/s13104-016-1840-x. PMID: 26758577
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
External database links

Locus tag (Gene) PA1862 (ModB)
Coordinates (Strand) 2021712..2022398 (-)
NCBI ID 15597059
RefSeq NC_002516
Uniprot ID Q9I2N3_PSEAE
KEGG ID pae:PA1862
PDB ID -
Pfam domain hit(s)

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Domain
Pfam ID
E-value
Aligned region
BPD_transp_1PF00528.244.5e-1831..217
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-14MALPLDSTDLAAIW
Transmembrane helix15-37LTIELASLTTLLLLLIGTPIAWW
Inside38-48LARTRSWLKGP
Transmembrane helix49-71IGAVVALPLVLPPTVIGFYLLVS
Outside72-85MGPNGFIGQLTQSL
Transmembrane helix86-108GLGTLPFTFAGLVVGSVFYSLPF
Inside109-138VVQPLQNAFEAIGEKPLEAAATLRASPVDR
Transmembrane helix139-161FFSVVLPLARPGFVTAAILGFAH
Outside162-196TVGEFGVVLMIGGNIPEKTRVVSVQIFDHVEAMEY
Transmembrane helix197-219AQAHWLAGGMVAFSFVVLLALYS
Inside220-228GRRRRPGWA


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.9988--


  Protein sequence: 229 a.a.    

>ACP00044 NC_002516:c2022398-2021712 [Pseudomonas aeruginosa PAO1]
MALPLDSTDLAAIWLTIELASLTTLLLLLIGTPIAWWLARTRSWLKGPIGAVVALPLVLPPTVIGFYLLVSMGPNGFIGQ
LTQSLGLGTLPFTFAGLVVGSVFYSLPFVVQPLQNAFEAIGEKPLEAAATLRASPVDRFFSVVLPLARPGFVTAAILGFA
HTVGEFGVVLMIGGNIPEKTRVVSVQIFDHVEAMEYAQAHWLAGGMVAFSFVVLLALYSGRRRRPGWA*

  Nucleotide sequence: 687 bp    

>ACP00044 NC_002516:c2022398-2021712 [Pseudomonas aeruginosa PAO1]
ATGGCGTTGCCACTCGACAGTACGGACCTGGCGGCCATCTGGCTGACCATCGAGCTGGCTTCGCTCACCACCCTCCTCCT
GCTGCTGATCGGCACGCCCATCGCCTGGTGGCTGGCGCGCACCCGCTCCTGGCTGAAGGGGCCGATCGGCGCGGTGGTGG
CCCTGCCGCTGGTGCTGCCGCCGACGGTGATCGGCTTCTACCTGCTGGTCAGCATGGGTCCCAACGGTTTCATCGGCCAG
CTCACCCAGAGCCTCGGTCTCGGCACCCTGCCCTTCACCTTCGCCGGTCTGGTGGTCGGTTCGGTGTTCTACTCGCTGCC
CTTCGTCGTGCAACCGTTGCAGAACGCCTTCGAGGCGATCGGCGAGAAACCGCTGGAGGCTGCCGCGACCCTGCGCGCGA
GCCCCGTCGACCGTTTCTTCAGCGTGGTCCTGCCGCTGGCCCGGCCGGGTTTCGTCACCGCCGCGATCCTCGGCTTCGCC
CATACCGTCGGCGAGTTCGGCGTGGTGCTGATGATCGGCGGCAACATCCCGGAGAAAACCCGCGTGGTCTCGGTGCAGAT
ATTCGATCACGTCGAAGCCATGGAATACGCCCAGGCCCACTGGCTGGCCGGCGGCATGGTGGCGTTCTCCTTCGTCGTCC
TCCTCGCCCTCTATTCGGGCCGGCGCCGCCGGCCGGGCTGGGCCTGA