Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01292  |
| T6SS type | Type i3 |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (GenBank) | chromosome II (CP009537) |
| Location | 1455143..1478378 |
| Function | - |
| Comment | The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection. |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AQ15_4673 | 1450693..1450950 | + | 258 | 772957316 | putative transposase for transposon | ||
| AQ15_4674 | 1451682..1452467 | + | 786 | 772958182 | hypothetical protein | ||
| AQ15_4675 | 1453017..1453523 | + | 507 | 772957151 | hypothetical protein | ||
| AQ15_4676 | 1453624..1454457 | - | 834 | 772958775 | RHS Repeat family protein | ||
| AQ15_4677 | 1454417..1455085 | - | 669 | 772957991 | hypothetical protein | ||
| T6CP013053 | TssI | AQ15_4678 | 1455143..1457347 | - | 2205 | 772957992 | Rhs element Vgr family protein |
| T6CP013054 | TssH | AQ15_4679 (clpV) | 1457344..1460010 | - | 2667 | 772957930 | type VI secretion ATPase, ClpV1 family |
| T6CP013055 | TssG | AQ15_4680 | 1459989..1461467 | - | 1479 | 772958403 | hypothetical protein |
| T6CP013056 | TssF | AQ15_4681 | 1461464..1463335 | - | 1872 | 772957615 | hypothetical protein |
| T6CP013057 | TssE | AQ15_4682 | 1463340..1463888 | - | 549 | 772957379 | 25-like lysozyme family protein |
| T6CP013058 | TssD | AQ15_4683 | 1463907..1464398 | - | 492 | 772956492 | hypothetical protein |
| T6CP013059 | TssC | AQ15_4684 | 1464458..1465966 | - | 1509 | 772957625 | hypothetical protein |
| T6CP013060 | TssB | AQ15_4685 | 1465959..1466537 | - | 579 | 772956821 | hypothetical protein |
| T6CP013061 | TssA | AQ15_4686 | 1466600..1467679 | - | 1080 | 772956845 | hypothetical protein |
| AQ15_4687 | 1467732..1470347 | - | 2616 | 772957665 | tyrosine kinase family protein | ||
| AQ15_4688 | 1470558..1471514 | - | 957 | 772957557 | hypothetical protein | ||
| T6CP013062 | TssM | AQ15_4689 | 1471496..1475125 | - | 3630 | 772957590 | intracellular multiplication and macrophage-killing family protein |
| T6CP013063 | TssL | AQ15_4690 | 1475128..1476444 | - | 1317 | 772957883 | type VI secretion system peptidoglycan-associated domain protein |
| T6CP013064 | TssK | AQ15_4691 | 1476460..1477863 | - | 1404 | 772956650 | hypothetical protein |
| T6CP013065 | TssJ | AQ15_4692 | 1477860..1478378 | - | 519 | 772957978 | type VI secretion lipofamily protein |
| AQ15_4693 | 1479018..1479419 | + | 402 | 772956569 | hypothetical protein | ||
| AQ15_4694 | 1479474..1480910 | + | 1437 | 772956607 | FHA domain protein | ||
| AQ15_4695 | 1480953..1482857 | - | 1905 | 772958106 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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