Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS01292 experimental
T6SS type Type i3
Strain Burkholderia pseudomallei K96243
Replicon (GenBank) chromosome II (CP009537)
Location 1455143..1478378
Function -
Comment The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection.
References
[1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number1111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
AQ15_4673 1450693..1450950 + 258 772957316 putative transposase for transposon
AQ15_4674 1451682..1452467 + 786 772958182 hypothetical protein
AQ15_4675 1453017..1453523 + 507 772957151 hypothetical protein
AQ15_4676 1453624..1454457 - 834 772958775 RHS Repeat family protein
AQ15_4677 1454417..1455085 - 669 772957991 hypothetical protein
T6CP013053 TssI AQ15_4678 1455143..1457347 - 2205 772957992 Rhs element Vgr family protein
T6CP013054 TssH AQ15_4679 (clpV) 1457344..1460010 - 2667 772957930 type VI secretion ATPase, ClpV1 family
T6CP013055 TssG AQ15_4680 1459989..1461467 - 1479 772958403 hypothetical protein
T6CP013056 TssF AQ15_4681 1461464..1463335 - 1872 772957615 hypothetical protein
T6CP013057 TssE AQ15_4682 1463340..1463888 - 549 772957379 25-like lysozyme family protein
T6CP013058 TssD AQ15_4683 1463907..1464398 - 492 772956492 hypothetical protein
T6CP013059 TssC AQ15_4684 1464458..1465966 - 1509 772957625 hypothetical protein
T6CP013060 TssB AQ15_4685 1465959..1466537 - 579 772956821 hypothetical protein
T6CP013061 TssA AQ15_4686 1466600..1467679 - 1080 772956845 hypothetical protein
AQ15_4687 1467732..1470347 - 2616 772957665 tyrosine kinase family protein
AQ15_4688 1470558..1471514 - 957 772957557 hypothetical protein
T6CP013062 TssM AQ15_4689 1471496..1475125 - 3630 772957590 intracellular multiplication and macrophage-killing family protein
T6CP013063 TssL AQ15_4690 1475128..1476444 - 1317 772957883 type VI secretion system peptidoglycan-associated domain protein
T6CP013064 TssK AQ15_4691 1476460..1477863 - 1404 772956650 hypothetical protein
T6CP013065 TssJ AQ15_4692 1477860..1478378 - 519 772957978 type VI secretion lipofamily protein
AQ15_4693 1479018..1479419 + 402 772956569 hypothetical protein
AQ15_4694 1479474..1480910 + 1437 772956607 FHA domain protein
AQ15_4695 1480953..1482857 - 1905 772958106 hypothetical protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector