Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00127  |
| T6SS type | Type i1 |
| Strain | Myxococcus xanthus DK 1622 |
| Replicon (RefSeq) | chromosome (NC_008095) |
| Location | 5996770..6055445 |
| Function | effector translocation |
| Comment | A deletion covering MXAN_4807-MXAN_4813 shows no growth defects or motility defects; however, the mutant is unable to form mature fruiting bodies (A. Konovalova, unpublished data). |
| References | [1] Chang YW et al (2014) Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography. Nat Methods. 11(7):737-9. [PudMed:24813625] [2] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] [3] Konovalova A et al (2010) Extracellular biology of Myxococcus xanthus. FEMS Microbiol Rev. 34(2):89-106. [PudMed:19895646] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagL | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 |
Loading, please wait
Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| MXAN_RS23295 | 5992055..5993263 | + | 1209 | WP_011554780.1 | ceramide glucosyltransferase | ||
| MXAN_RS23300 | 5993383..5993763 | + | 381 | WP_171452214.1 | response regulator | ||
| MXAN_RS23305 | 5993842..5995125 | + | 1284 | WP_011554782.1 | hemolysin family protein | ||
| MXAN_RS23310 | 5995148..5996368 | - | 1221 | WP_020478478.1 | fibronectin type III domain-containing protein | ||
| MXAN_RS23320 | 5996770..6001965 | - | 5196 | WP_011554784.1 | hypothetical protein | ||
| T6CP011373 | TagL | MXAN_RS23325 | 6001993..6003840 | - | 1848 | WP_011554785.1 | OmpA family protein |
| T6CP001230 | TssI | MXAN_RS23330 (tssI) | 6004071..6006335 | + | 2265 | WP_011554786.1 | type VI secretion system tip protein VgrG |
| T6CP001231 | TssJ | MXAN_RS23335 (tssJ) | 6006481..6007098 | + | 618 | WP_011554787.1 | type VI secretion system lipoprotein TssJ |
| T6CP001232 | TssK | MXAN_RS23340 (tssK) | 6007095..6008462 | + | 1368 | WP_011554788.1 | type VI secretion system baseplate subunit TssK |
| T6CP001233 | TssL | MXAN_RS23345 | 6008478..6009194 | + | 717 | WP_011554789.1 | DotU family type IV/VI secretion system protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Loading, please wait
Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01476 | MXAN_5572 (TsxE) | Tae | IMU00302 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 6920542..6922551 (-) | 108462560 |
| EFF01483 | MXAN_RS00265 | Tde | IMU00308 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 57099..57971 (-) | 499869465 |
| EFF01808 | MXAN_RS36995 (PAAR-CTD) | Tde | IMU00377 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 6338694..6339836 (-) | 1174098909 |
| EFF01809 | MXAN_RS08765 (PAAR-CTD) | Tse | IMU00378 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 2144359..2145612 (-) | 499871184 |
| EFF01313 | MXAN_4809 (hcp) | - | - | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 6018067..6018558 (+) | 108762846 |
Showing 1 to 5 of 5 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00302 | MXAN_5571 (TsxI) | EFF01476 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 6919379..6920530 (-) | 108762153 |
| IMU00308 | MXAN_RS00260 | EFF01483 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 56489..57073 (-) | 499869464 |
| IMU00377 | MXAN_RS24590 | EFF01808 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 6337957..6338418 (-) | 521967099 |
| IMU00378 | MXAN_RS08760 | EFF01809 | Myxococcus xanthus DK 1622 | chromosome (NC_008095) | 2143618..2143965 (-) | 521967337 |
Showing 1 to 4 of 4 rows
Experimental investigation has been performed.
Loading, please wait
Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||