Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00464  |
| T6SS type | Type i4b |
| Strain | Escherichia coli 042 |
| Replicon (RefSeq) | chromosome (NC_017626) |
| Location | 4893076..4921378 |
| Function | effector translocation |
| Comment | - |
| References | [1] Dudley EG et al (2006) Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] [2] Morin N et al (2013) Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| EC042_RS24320 | 4888303..4888947 | + | 645 | WP_000502863.1 | ParB N-terminal domain-containing protein | ||
| EC042_RS24325 | 4889026..4889295 | + | 270 | WP_000226517.1 | PerC family transcriptional regulator | ||
| EC042_RS24330 | 4889316..4889960 | + | 645 | WP_001387055.1 | hypothetical protein | ||
| EC042_RS24335 | 4890026..4890349 | + | 324 | WP_001387054.1 | hypothetical protein | ||
| EC042_RS24340 | 4890380..4890959 | - | 580 | pseudogene | transposase family protein | ||
| EC042_RS24350 | 4891169..4891555 | + | 387 | WP_014966195.1 | hypothetical protein | ||
| EC042_RS28855 | 4891533..4891658 | + | 126 | WP_001420591.1 | hypothetical protein | ||
| EC042_RS24355 | 4891664..4892680 | - | 1017 | pseudogene | IS630 family transposase | ||
| T6CP005141 | TssB | EC042_RS24360 (tssB) | 4893076..4893552 | + | 477 | WP_000072549.1 | type VI secretion system contractile sheath small subunit |
| T6CP005142 | TssC | EC042_RS24365 (tssC) | 4893555..4895033 | + | 1479 | WP_000215053.1 | type VI secretion system contractile sheath large subunit |
| EC042_RS24370 (aaiC) | 4895043..4895549 | + | 507 | WP_000233190.1 | type VI secretion system protein AaiC/Hcp2 | ||
| T6CP009340 | TssE | EC042_RS24375 | 4895559..4895981 | + | 423 | WP_000555548.1 | hypothetical protein |
| T6CP005143 | TssF | EC042_RS24380 (tssF) | 4895974..4897776 | + | 1803 | WP_001390300.1 | type VI secretion system baseplate subunit TssF |
| T6CP005144 | TssG | EC042_RS24385 (tssG) | 4897767..4898699 | + | 933 | WP_001173973.1 | type VI secretion system baseplate subunit TssG |
| T6CP005145 | TssI | EC042_RS24390 (tssI) | 4898712..4900694 | + | 1983 | WP_000198270.1 | type VI secretion system tip protein VgrG |
| EC042_RS24395 | 4900705..4901172 | + | 468 | WP_000005080.1 | hypothetical protein | ||
| T6CP011360 | PAAR | EC042_RS24400 | 4901182..4901481 | + | 300 | WP_001390299.1 | PAAR domain-containing protein |
| T6CP005146 | TssA | EC042_RS24405 (tssA) | 4901485..4902561 | + | 1077 | WP_001033155.1 | type VI secretion system protein TssA |
| T6CP009341 | TssJ | EC042_RS24410 | 4902569..4903120 | + | 552 | WP_000152745.1 | type VI secretion lipoprotein TssJ |
| T6CP005147 | TssK | EC042_RS24415 (tssK) | 4903139..4904551 | + | 1413 | WP_001154665.1 | type VI secretion system baseplate subunit TssK |
| T6CP005148 | TssL | EC042_RS24425 | 4904890..4905480 | + | 591 | WP_001028111.1 | DotU family type IV/VI secretion system protein |
| T6CP009063 | TssM | EC042_RS24430 | 4905486..4908890 | + | 3405 | WP_001403210.1 | hypothetical protein |
| T6CP005149 | TssH | EC042_RS24435 (tssH) | 4908894..4911443 | + | 2550 | WP_000029849.1 | type VI secretion system ATPase TssH |
| EC042_RS29735 | 4911640..4912851 | + | 1212 | pseudogene | IS3 family transposase | ||
| EC042_RS30855 | 4914614..4915180 | + | 567 | WP_000587872.1 | hypothetical protein | ||
| EC042_RS30410 | 4915245..4915525 | + | 281 | pseudogene | transposase | ||
| EC042_RS24460 | 4915659..4916813 | + | 1155 | WP_000359994.1 | type VI secretion system ImpA family N-terminal domain-containing protein | ||
| EC042_RS24470 | 4917879..4918067 | - | 189 | pseudogene | IS66 family transposase | ||
| EC042_RS24475 | 4918128..4919261 | + | 1134 | WP_000555380.1 | IS110 family transposase | ||
| EC042_RS27045 | 4919301..4919663 | + | 363 | WP_077577697.1 | IS3 family transposase | ||
| EC042_RS28895 | 4919667..4919810 | + | 144 | pseudogene | IS3 family transposase | ||
| EC042_RS24485 | 4919996..4920184 | - | 189 | pseudogene | IS66 family transposase | ||
| EC042_RS24490 | 4920245..4921378 | + | 1134 | WP_000555401.1 | IS110-like element ISEc45 family transposase | ||
| EC042_RS24495 | 4921632..4923056 | - | 1425 | pseudogene | IS66-like element ISEc43 family transposase | ||
| EC042_RS24500 (tnpB) | 4923087..4923437 | - | 351 | WP_000624688.1 | IS66 family insertion sequence element accessory protein TnpB | ||
| EC042_RS24505 | 4923434..4923868 | - | 435 | WP_001309734.1 | IS66 family insertion sequence hypothetical protein | ||
| EC042_RS24510 | 4923956..4924408 | + | 453 | pseudogene | transposase | ||
| EC042_RS24515 | 4924447..4924689 | + | 243 | pseudogene | IS256 family transposase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00561 |
EC042_4564 (AaiC) | - | - | Escherichia coli 042 | chromosome (NC_017626) | 4895043..4895549 (+) | 387609980 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|