Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00464  |
| T6SS type | Type i4b |
| Strain | Escherichia coli 042 |
| Replicon (RefSeq) | chromosome (NC_017626) |
| Location | 4893076..4921378 |
| Function | effector translocation |
| Comment | - |
| References | [1] Dudley EG et al (2006) Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] [2] Morin N et al (2013) Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| EC042_RS24320 | 4888303..4888947 | + | 645 | WP_000502863.1 | ParB N-terminal domain-containing protein | ||
| EC042_RS24325 | 4889026..4889295 | + | 270 | WP_000226517.1 | PerC family transcriptional regulator | ||
| EC042_RS24330 | 4889316..4889960 | + | 645 | WP_001387055.1 | hypothetical protein | ||
| EC042_RS24335 | 4890026..4890349 | + | 324 | WP_001387054.1 | hypothetical protein | ||
| EC042_RS24340 | 4890380..4890959 | - | 580 | pseudogene | transposase family protein | ||
| EC042_RS24350 | 4891169..4891555 | + | 387 | WP_014966195.1 | hypothetical protein | ||
| EC042_RS28855 | 4891533..4891658 | + | 126 | WP_001420591.1 | hypothetical protein | ||
| EC042_RS24355 | 4891664..4892680 | - | 1017 | pseudogene | IS630 family transposase | ||
| T6CP005141 | TssB | EC042_RS24360 (tssB) | 4893076..4893552 | + | 477 | WP_000072549.1 | type VI secretion system contractile sheath small subunit |
| T6CP005142 | TssC | EC042_RS24365 (tssC) | 4893555..4895033 | + | 1479 | WP_000215053.1 | type VI secretion system contractile sheath large subunit |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0248 | EC042_RS26480 (aggR) | protein | Transcription regulator | Escherichia coli 042 | plasmid (NC_017627) | 41080..41877 (-) | 446692110 | EC042_RS26480 (aggR) promoter (↓); EC042_RS26480 (aggR) promoter (↓) |
| REG0249 | EC042_RS18855 (FIS) | protein | Transcription regulator | Escherichia coli 042 | chromosome (NC_017626) | 3772795..3773091 (+) | 446385050 | EC042_RS26480 (aggR) promoter (↓) |
| REG0250 | EC042_RS06800 (Hns) | protein | Global regulator | Escherichia coli 042 | chromosome (NC_017626) | 1376831..1377244 (-) | 447210122 | EC042_RS26480 (aggR) promoter (↑) |
| REG0251 | EC042_RS03685 (Fur) | protein | Global regulator | Escherichia coli 042 | chromosome (NC_017626) | 786918..787364 (-) | 446053847 | EC042_4532 promoter (↑); EC042_4524 (TssB) promotor (↑) |
| REG0252 | EC042_RS19435 (Dam) | protein | Global regulator | Escherichia coli 042 | chromosome (NC_017626) | 3861171..3862007 (-) | 446664793 | EC042_4532 promoter (↑) |
Showing 1 to 5 of 5 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00561 | EC042_4564 (AaiC) | - | - | Escherichia coli 042 | chromosome (NC_017626) | 4895043..4895549 (+) | 387609980 |
Showing 1 to 1 of 1 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||