Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS13923  |
| T6SS type | Type i3 |
| Strain | Enterobacter sp. DSM 30060 |
| Replicon (RefSeq) | chromosome (NZ_CP056118) |
| Location | 4465150..4496796 |
| Function | anti-bacterial |
| Comment | Deleteion of the tssB1 gene in those predatory strains that were genetically tractable, which abrogated their interbacterial killing capacity. Significant killing of E. coli by the WT E. hormaechei strain DSM 30060 was observed when compared with its T6SS-1-deficient variant, while this was not the case when V. cholerae served as prey, suggesting a certain degree of target specificity. |
| References | [1] Flaugnatti N, Isaac S, Lemos Rocha LF, Stutzmann S, Rendueles O, Stoudmann C, Vesel N, Garcia-Garcera M, Buffet A, Sana TG, Rocha EPC, Blokesch M. et al (2021) Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms.. Nat Commun. 12(1):5751. [PudMed:34599171] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | Tae4 | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| HWQ15_RS21290 | 4463994..4464434 | - | 441 | WP_038416219.1 | DUF1795 domain-containing protein | ||
| HWQ15_RS21295 | 4464642..4465160 | - | 519 | WP_063148595.1 | hypothetical protein | ||
| T6CP207877 | TssI | HWQ15_RS21300 | 4465150..4467732 | - | 2583 | WP_063849903.1 | type VI secretion system tip protein VgrG |
| HWQ15_RS21305 | 4467817..4468272 | - | 456 | WP_032622425.1 | hypothetical protein | ||
| HWQ15_RS21310 | 4468286..4469032 | - | 747 | WP_063216306.1 | Accessory protein | ||
| T6CP207878 | TssI | HWQ15_RS21315 | 4469044..4470510 | - | 1467 | WP_023300317.1 | hypothetical protein |
| HWQ15_RS21320 | 4470536..4471969 | - | 1434 | WP_023300318.1 | serine/threonine protein kinase | ||
| T6CP207880 | TssH | HWQ15_RS21325 (tssH) | 4471994..4474609 | - | 2616 | WP_063138102.1 | type VI secretion system ATPase TssH |
| T6CP207881 | TssG | HWQ15_RS21330 (tssG) | 4474648..4475691 | - | 1044 | WP_022648402.1 | type VI secretion system baseplate subunit TssG |
| T6CP207882 | TssF | HWQ15_RS21335 (tssF) | 4475688..4477559 | - | 1872 | WP_063148593.1 | type VI secretion system baseplate subunit TssF |
| T6CP207883 | TssE | HWQ15_RS21340 (tssE) | 4477562..4478125 | - | 564 | WP_015570336.1 | type VI secretion system baseplate subunit TssE |
| HWQ15_RS21345 | 4478118..4478930 | - | 813 | WP_022648404.1 | type VI secretion system protein ImpE | ||
| HWQ15_RS21350 | 4478940..4479926 | - | 987 | WP_022648405.1 | hypothetical protein | ||
| HWQ15_RS21355 | 4479943..4480740 | - | 798 | WP_022648406.1 | protein phosphatase 2C domain-containing protein | ||
| HWQ15_RS21360 (tagH) | 4480737..4482512 | - | 1776 | WP_063148592.1 | type VI secretion system-associated FHA domain protein TagH | ||
| HWQ15_RS21365 | 4482603..4483019 | - | 417 | WP_063148591.1 | hypothetical protein | ||
| HWQ15_RS21370 | 4483013..4484002 | - | 990 | WP_015570333.1 | hypothetical protein | ||
| T6CP207887 | TssD | HWQ15_RS21375 | 4484078..4484560 | - | 483 | WP_014884229.1 | type VI secretion system tube protein Hcp |
| HWQ15_RS21380 | 4484741..4485142 | - | 402 | WP_045623221.1 | hypothetical protein | ||
| T6CP207888 | Tae4 | HWQ15_RS21385 | 4485175..4485669 | - | 495 | WP_022648411.1 | hypothetical protein |
| HWQ15_RS21390 | 4485673..4486098 | - | 426 | WP_038416233.1 | hypothetical protein | ||
| T6CP207889 | TssC | HWQ15_RS21395 (tssC) | 4486178..4487677 | - | 1500 | WP_006810956.1 | type VI secretion system contractile sheath large subunit |
| T6CP207890 | TssB | HWQ15_RS21400 (tssB) | 4487681..4488205 | - | 525 | WP_022648413.1 | type VI secretion system contractile sheath small subunit |
| T6CP207891 | TssA | HWQ15_RS21405 (tssA) | 4488281..4489297 | - | 1017 | WP_023300332.1 | type VI secretion system protein TssA |
| HWQ15_RS21410 (tagF) | 4489309..4490025 | - | 717 | WP_045308303.1 | type VI secretion system-associated protein TagF | ||
| T6CP207893 | TssM | HWQ15_RS21415 (tssM) | 4490042..4493662 | - | 3621 | WP_063148588.1 | type VI secretion system membrane subunit TssM |
| T6CP207894 | TssL | HWQ15_RS21420 | 4493665..4494903 | - | 1239 | WP_003859963.1 | DotU family type VI secretion system protein |
| T6CP207895 | TssK | HWQ15_RS21425 (tssK) | 4494921..4496264 | - | 1344 | WP_022648417.1 | type VI secretion system baseplate subunit TssK |
| T6CP207896 | TssJ | HWQ15_RS21430 (tssJ) | 4496293..4496796 | - | 504 | WP_022648418.1 | type VI secretion system lipoprotein TssJ |
| HWQ15_RS21435 | 4496820..4497314 | - | 495 | WP_006810964.1 | hypothetical protein | ||
| HWQ15_RS21440 | 4498245..4499225 | + | 981 | WP_022648419.1 | helix-turn-helix domain-containing protein | ||
| HWQ15_RS21445 (gap) | 4499304..4500314 | + | 1011 | WP_023306461.1 | type I glyceraldehyde-3-phosphate dehydrogenase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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