Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00009  |
| T6SS type | Type i3 |
| Strain | Bordetella bronchiseptica RB50 |
| Replicon (RefSeq) | chromosome (NC_002927) |
| Location | 825621..868006 |
| Function | anti-eukaryotic; virulence |
| Comment | Required for Bordetella bronchiseptica immunomodulation and persistence in vivo; T6SS contributes to cytotoxicity of murine macrophages; T6SS is required for persistence in the murine respiratory tract; T6SS mediates increased pathology and cell recruitment in vivo; T6SS modulates a Th1 immune response. |
| References | [1] Weyrich LS et al (2012) A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo. PLoS One. 7(10):e45892. [PudMed:23071529] [2] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AYT36_RS03965 | 821685..822587 | - | 903 | WP_003808247.1 | tetratricopeptide repeat protein | ||
| AYT36_RS03970 (mshL) | 822584..824221 | - | 1638 | WP_003808249.1 | pilus (MSHA type) biogenesis protein MshL | ||
| AYT36_RS03975 | 824235..824999 | - | 765 | WP_010925939.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | ||
| AYT36_RS03980 | 824996..825595 | - | 600 | WP_010925940.1 | hypothetical protein | ||
| AYT36_RS03985 | 825621..826130 | - | 510 | WP_003808255.1 | hypothetical protein | ||
| AYT36_RS03990 | 826127..827497 | - | 1371 | WP_010925941.1 | hypothetical protein | ||
| AYT36_RS03995 | 827502..828008 | - | 507 | WP_003819516.1 | hypothetical protein | ||
| AYT36_RS04000 | 828015..828809 | - | 795 | WP_003808263.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | ||
| AYT36_RS04005 | 828844..829884 | - | 1041 | WP_003808265.1 | type IV pilus twitching motility protein PilT | ||
| AYT36_RS04010 | 830131..830958 | + | 828 | WP_010925942.1 | A24 family peptidase | ||
| T6CP000065 | TssI | AYT36_RS04015 (tssI) | 831107..833470 | + | 2364 | WP_003808272.1 | type VI secretion system tip protein VgrG |
| AYT36_RS04020 | 833487..833900 | + | 414 | WP_010925943.1 | DUF3592 domain-containing protein | ||
| AYT36_RS04025 | 833897..836521 | + | 2625 | WP_010925944.1 | DUF2169 domain-containing protein | ||
| AYT36_RS04030 | 836511..837572 | + | 1062 | WP_010925945.1 | pentapeptide repeat-containing protein | ||
| AYT36_RS04035 | 837603..838511 | + | 909 | WP_003808280.1 | DUF4150 domain-containing protein | ||
| AYT36_RS04040 | 838552..839112 | + | 561 | WP_003808282.1 | suppressor of fused domain protein | ||
| T6CP000066 | TssA | AYT36_RS04045 (tssA) | 839536..840564 | + | 1029 | WP_033446914.1 | type VI secretion system protein TssA |
| T6CP000067 | TssB | AYT36_RS04050 (tssB) | 840607..841170 | + | 564 | WP_003808284.1 | type VI secretion system contractile sheath small subunit |
| T6CP000068 | TssC | AYT36_RS04055 (tssC) | 841192..842694 | + | 1503 | WP_003808286.1 | type VI secretion system contractile sheath large subunit |
| T6CP000069 | TssD | AYT36_RS04060 | 842752..843237 | + | 486 | WP_033449640.1 | type VI secretion system tube protein Hcp |
| T6CP012695 | TagJ | AYT36_RS04065 | 843287..844096 | + | 810 | WP_010925947.1 | hypothetical protein |
| T6CP000070 | TssE | AYT36_RS04070 (tssE) | 844093..844611 | + | 519 | WP_003808292.1 | type VI secretion system baseplate subunit TssE |
| T6CP000071 | TssF | AYT36_RS04075 (tssF) | 844611..846524 | + | 1914 | WP_010925948.1 | type VI secretion system baseplate subunit TssF |
| AYT36_RS04080 | 846559..847218 | + | 660 | WP_010925949.1 | DUF3540 domain-containing protein | ||
| T6CP000072 | TssG | AYT36_RS04085 (tssG) | 847215..848309 | + | 1095 | WP_010925950.1 | type VI secretion system baseplate subunit TssG |
| AYT36_RS04090 | 848306..848839 | + | 534 | WP_003808301.1 | DUF2778 domain-containing protein | ||
| AYT36_RS04095 | 848829..849206 | + | 378 | WP_003808303.1 | DUF2195 family protein | ||
| T6CP000073 | TssH | AYT36_RS04100 (tssH) | 849230..851839 | + | 2610 | WP_010925951.1 | type VI secretion system ATPase TssH |
| T6CP011386 | FHA | AYT36_RS04105 | 851938..852738 | - | 801 | WP_003808308.1 | hypothetical protein |
| AYT36_RS04110 | 852766..853161 | - | 396 | WP_010925952.1 | TssQ family T6SS-associated lipoprotein | ||
| T6CP000074 | TssJ | AYT36_RS04115 (tssJ) | 853426..853968 | + | 543 | WP_010925953.1 | type VI secretion system lipoprotein TssJ |
| T6CP000075 | TssK | AYT36_RS04120 (tssK) | 854014..855348 | + | 1335 | WP_003808316.1 | type VI secretion system baseplate subunit TssK |
| T6CP000076 | TssL | AYT36_RS04125 | 855369..856649 | + | 1281 | WP_003808318.1 | DotU family type VI secretion system protein |
| T6CP000077 | TssM | AYT36_RS04130 (tssM) | 856646..860251 | + | 3606 | WP_010925954.1 | type VI secretion system membrane subunit TssM |
| AYT36_RS04135 (tagF) | 860248..860982 | + | 735 | WP_010925955.1 | type VI secretion system-associated protein TagF | ||
| AYT36_RS04140 | 861007..862185 | + | 1179 | WP_010925956.1 | hypothetical protein | ||
| AYT36_RS04145 | 862283..863449 | + | 1167 | WP_003808328.1 | calcium:proton antiporter | ||
| AYT36_RS04150 | 863623..865035 | + | 1413 | WP_010925957.1 | DUF1254 domain-containing protein | ||
| AYT36_RS04155 | 865043..868006 | - | 2964 | WP_003808333.1 | BB0821 family autotransporter | ||
| AYT36_RS04160 | 868456..869934 | + | 1479 | WP_003808335.1 | phospholipase D family protein | ||
| AYT36_RS04165 (modC) | 869941..871050 | - | 1110 | WP_010925958.1 | molybdenum ABC transporter ATP-binding protein | ||
| AYT36_RS04170 (modB) | 871062..871742 | - | 681 | WP_003808339.1 | molybdate ABC transporter permease subunit | ||
| AYT36_RS04175 (modA) | 871764..872519 | - | 756 | WP_003808340.1 | molybdate ABC transporter substrate-binding protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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