Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00009  |
| T6SS type | Type i3 |
| Strain | Bordetella bronchiseptica RB50 |
| Replicon (RefSeq) | chromosome (NC_002927) |
| Location | 825621..868006 |
| Function | anti-eukaryotic; virulence |
| Comment | Required for Bordetella bronchiseptica immunomodulation and persistence in vivo; T6SS contributes to cytotoxicity of murine macrophages; T6SS is required for persistence in the murine respiratory tract; T6SS mediates increased pathology and cell recruitment in vivo; T6SS modulates a Th1 immune response. |
| References | [1] Weyrich LS et al (2012) A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo. PLoS One. 7(10):e45892. [PudMed:23071529] [2] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Loading, please wait
Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AYT36_RS03965 | 821685..822587 | - | 903 | WP_003808247.1 | tetratricopeptide repeat protein | ||
| AYT36_RS03970 (mshL) | 822584..824221 | - | 1638 | WP_003808249.1 | pilus (MSHA type) biogenesis protein MshL | ||
| AYT36_RS03975 | 824235..824999 | - | 765 | WP_010925939.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | ||
| AYT36_RS03980 | 824996..825595 | - | 600 | WP_010925940.1 | hypothetical protein | ||
| AYT36_RS03985 | 825621..826130 | - | 510 | WP_003808255.1 | hypothetical protein | ||
| AYT36_RS03990 | 826127..827497 | - | 1371 | WP_010925941.1 | hypothetical protein | ||
| AYT36_RS03995 | 827502..828008 | - | 507 | WP_003819516.1 | hypothetical protein | ||
| AYT36_RS04000 | 828015..828809 | - | 795 | WP_003808263.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | ||
| AYT36_RS04005 | 828844..829884 | - | 1041 | WP_003808265.1 | type IV pilus twitching motility protein PilT | ||
| AYT36_RS04010 | 830131..830958 | + | 828 | WP_010925942.1 | A24 family peptidase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Loading, please wait
Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
Loading, please wait
Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||