Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00935 experimental
T6SS type Type i2
Strain Escherichia coli 17-2
Replicon (RefSeq) chromosome (NZ_JACEFV010000001)
Location 909481..942047
Function anti-eukaryotic; effector translocation
Comment sci-1 gene cluster is involved in biofilm formation.
References
[1] Aschtgen MS et al (2008) SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. J Bacteriol. 190(22):7523-31. [PudMed:18805985]
[2] Zoued A et al (2013) TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384]
[3] Nguyen VS et al (2015) Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody. PLoS One. 10(3):e0122187. [PudMed:25811612]
[4] Durand E et al (2012) Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492]
[5] Aschtgen MS et al (2012) The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. Microbiologyopen. 1(1):71-82. [PudMed:22950014]
[6] Felisberto-Rodrigues C et al (2011) Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820]
[7] Aschtgen MS et al (2010) The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall. Mol Microbiol. 75(4):886-99. [PudMed:20487285]
[8] Brunet YR et al (2013) Imaging Type VI Secretion-Mediated Bacterial Killing. Cell Rep. 3(1):36-41. [PudMed:23291094]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssL
Number211111111111


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Component ID
Component
Locus tag (Gene)
Coordinate
Strand
Size (bp)
NCBI ID
Product
H1D38_RS04315904569..904892-324485761811hypothetical protein
H1D38_RS04320904958..905602-645485761812hypothetical protein
H1D38_RS04325905623..905892-270446148662PerC family transcriptional regulator
H1D38_RS04330905971..906615-645446425008ParB N-terminal domain-containing protein
H1D38_RS04335906600..907832-1233447127386phosphoadenosine phosphosulfate reductase
H1D38_RS04340907873..908703-831446293040hypothetical protein
H1D38_RS04345908706..909266-561446508647hypothetical protein
T6CP016069TssAH1D38_RS04350909481..910848-1368446122356type VI secretion system ImpA family N-terminal domain-containing protein
H1D38_RS04355910903..911208-306485799642hypothetical protein
H1D38_RS04360911273..913018-1746485765580AAA family ATPase
Showing 1 to 10 of 43 rows rows per page
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Regulator ID
Locus tag (Gene)
Regulator type
Regulatory pathway
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Target (Regulation)
No matching records found

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Effector ID
Locus tag (Gene)
Classification
Cognate immunity protein
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
No matching records found

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Immunity protein ID
Locus tag (Gene)
Cognate effector
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
No matching records found

experimental Experimental investigation has been performed.
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Accessory protein ID
Locus tag (Gene)
Type            
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Related structure protein
Related effector
No matching records found