Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00935 ![]() |
T6SS type | Type i2 |
Strain | Escherichia coli 17-2 |
Replicon (RefSeq) | chromosome (NZ_JACEFV010000001) |
Location | 909481..942047 |
Function | anti-eukaryotic; effector translocation |
Comment | sci-1 gene cluster is involved in biofilm formation. |
References | [1] Aschtgen MS et al (2008) SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. J Bacteriol. 190(22):7523-31. [PudMed:18805985] [2] Zoued A et al (2013) TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384] [3] Nguyen VS et al (2015) Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody. PLoS One. 10(3):e0122187. [PudMed:25811612] [4] Durand E et al (2012) Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492] [5] Aschtgen MS et al (2012) The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. Microbiologyopen. 1(1):71-82. [PudMed:22950014] [6] Felisberto-Rodrigues C et al (2011) Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820] [7] Aschtgen MS et al (2010) The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall. Mol Microbiol. 75(4):886-99. [PudMed:20487285] [8] Brunet YR et al (2013) Imaging Type VI Secretion-Mediated Bacterial Killing. Cell Rep. 3(1):36-41. [PudMed:23291094] |

T6SS components and genome coordinates
Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |

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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
H1D38_RS04315 | 904569..904892 | - | 324 | 485761811 | hypothetical protein | ||
H1D38_RS04320 | 904958..905602 | - | 645 | 485761812 | hypothetical protein | ||
H1D38_RS04325 | 905623..905892 | - | 270 | 446148662 | PerC family transcriptional regulator | ||
H1D38_RS04330 | 905971..906615 | - | 645 | 446425008 | ParB N-terminal domain-containing protein | ||
H1D38_RS04335 | 906600..907832 | - | 1233 | 447127386 | phosphoadenosine phosphosulfate reductase | ||
H1D38_RS04340 | 907873..908703 | - | 831 | 446293040 | hypothetical protein | ||
H1D38_RS04345 | 908706..909266 | - | 561 | 446508647 | hypothetical protein | ||
T6CP016069 | TssA | H1D38_RS04350 | 909481..910848 | - | 1368 | 446122356 | type VI secretion system ImpA family N-terminal domain-containing protein |
H1D38_RS04355 | 910903..911208 | - | 306 | 485799642 | hypothetical protein | ||
H1D38_RS04360 | 911273..913018 | - | 1746 | 485765580 | AAA family ATPase |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.


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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
---|---|---|---|---|---|---|---|---|
No matching records found |


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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|---|
No matching records found |


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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|
No matching records found |

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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
---|---|---|---|---|---|---|---|---|
No matching records found |