Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00935 |
T6SS type | Type i2 |
Strain | Escherichia coli 17-2 |
Replicon (RefSeq) | chromosome (NZ_JACEFV010000001) |
Location | 909481..942047 |
Function | anti-eukaryotic; effector translocation |
Comment | sci-1 gene cluster is involved in biofilm formation. |
References | [1] Aschtgen MS et al (2008) SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. J Bacteriol. 190(22):7523-31. [PudMed:18805985] [2] Zoued A et al (2013) TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384] [3] Nguyen VS et al (2015) Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody. PLoS One. 10(3):e0122187. [PudMed:25811612] [4] Durand E et al (2012) Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492] [5] Aschtgen MS et al (2012) The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. Microbiologyopen. 1(1):71-82. [PudMed:22950014] [6] Felisberto-Rodrigues C et al (2011) Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820] [7] Aschtgen MS et al (2010) The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall. Mol Microbiol. 75(4):886-99. [PudMed:20487285] [8] Brunet YR et al (2013) Imaging Type VI Secretion-Mediated Bacterial Killing. Cell Rep. 3(1):36-41. [PudMed:23291094] |
T6SS components and genome coordinates
Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
H1D38_RS04315 | 904569..904892 | - | 324 | 485761811 | hypothetical protein | ||
H1D38_RS04320 | 904958..905602 | - | 645 | 485761812 | hypothetical protein | ||
H1D38_RS04325 | 905623..905892 | - | 270 | 446148662 | PerC family transcriptional regulator | ||
H1D38_RS04330 | 905971..906615 | - | 645 | 446425008 | ParB N-terminal domain-containing protein | ||
H1D38_RS04335 | 906600..907832 | - | 1233 | 447127386 | phosphoadenosine phosphosulfate reductase | ||
H1D38_RS04340 | 907873..908703 | - | 831 | 446293040 | hypothetical protein | ||
H1D38_RS04345 | 908706..909266 | - | 561 | 446508647 | hypothetical protein | ||
T6CP016069 | TssA | H1D38_RS04350 | 909481..910848 | - | 1368 | 446122356 | type VI secretion system ImpA family N-terminal domain-containing protein |
H1D38_RS04355 | 910903..911208 | - | 306 | 485799642 | hypothetical protein | ||
H1D38_RS04360 | 911273..913018 | - | 1746 | 485765580 | AAA family ATPase | ||
H1D38_RS04365 | 913254..914504 | - | 1251 | 446819774 | GIY-YIG nuclease family protein | ||
H1D38_RS04370 | 914660..915061 | - | 402 | 485781047 | hypothetical protein | ||
T6CP016070 | TssE | H1D38_RS04375 (tssE) | 915218..915649 | - | 432 | 447060676 | type VI secretion system baseplate subunit TssE |
T6CP016071 | TssJ | H1D38_RS04380 (tssJ) | 915652..916188 | - | 537 | 446897213 | type VI secretion system lipoprotein TssJ |
T6CP016072 | TssG | H1D38_RS04385 (tssG) | 916169..917269 | - | 1101 | 446475927 | type VI secretion system baseplate subunit TssG |
T6CP016073 | TssF | H1D38_RS04390 (tssF) | 917224..918987 | - | 1764 | 446264608 | type VI secretion system baseplate subunit TssF |
H1D38_RS04395 | 918995..919687 | - | 693 | 446037502 | hypothetical protein | ||
T6CP016074 | TssA | H1D38_RS04400 (tssA) | 919689..921287 | - | 1599 | 446068660 | type VI secretion system protein TssA |
H1D38_RS04405 | 921287..924676 | - | 3390 | 446959833 | type VI secretion protein VasK | ||
H1D38_RS04410 | 924669..925817 | - | 1149 | 485781045 | hypothetical protein | ||
H1D38_RS04415 | 925821..926087 | - | 267 | 445955555 | PAAR domain-containing protein | ||
H1D38_RS04420 (tli1) | 926119..926795 | - | 677 | pseudogene | T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC | ||
H1D38_RS04425 (tli1) | 926939..927615 | - | 677 | pseudogene | T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC | ||
H1D38_RS04430 (tle1) | 927635..929317 | - | 1683 | 446092701 | T6SS effector phospholipase Tle1-EAEC | ||
T6CP016075 | TssI | H1D38_RS04435 (vgrG) | 929314..931839 | - | 2526 | 446977247 | type VI secretion system tip protein VgrG |
H1D38_RS04440 | 931826..932368 | - | 543 | 485781044 | hypothetical protein | ||
H1D38_RS04445 | 932362..932928 | - | 567 | 446070506 | hypothetical protein | ||
T6CP016076 | TssH | H1D38_RS04450 (tssH) | 932925..935582 | - | 2658 | 446353791 | type VI secretion system ATPase TssH |
T6CP016077 | TssD | H1D38_RS04455 (hcp) | 935751..936242 | - | 492 | 446930057 | type VI secretion system effector Hcp |
H1D38_RS04460 | 936248..937978 | - | 1731 | 446480629 | OmpA family protein | ||
T6CP016078 | TssL | H1D38_RS04465 (tssL) | 937981..938634 | - | 654 | 446962789 | type VI secretion system protein TssL, short form |
T6CP016079 | TssK | H1D38_RS04470 (tssK) | 938631..939968 | - | 1338 | 446631292 | type VI secretion system baseplate subunit TssK |
T6CP016080 | TssC | H1D38_RS04475 (tssC) | 939984..941528 | - | 1545 | 446852935 | type VI secretion system contractile sheath large subunit |
T6CP016081 | TssB | H1D38_RS04480 (tssB) | 941550..942047 | - | 498 | 446021084 | type VI secretion system contractile sheath small subunit |
H1D38_RS04485 | 942554..942745 | + | 192 | 447210540 | DUF4222 domain-containing protein | ||
H1D38_RS04490 | 942798..943031 | - | 234 | 446046326 | hypothetical protein | ||
H1D38_RS04495 | 943127..943750 | - | 624 | 447183010 | hypothetical protein | ||
H1D38_RS04500 | 944059..944478 | - | 420 | 485761816 | hypothetical protein | ||
H1D38_RS04505 | 944468..944851 | - | 384 | 446193167 | hypothetical protein | ||
H1D38_RS04510 | 944823..944981 | - | 159 | 446415670 | hypothetical protein | ||
H1D38_RS04515 | 945019..945588 | - | 570 | 446142872 | inovirus Gp2 family protein | ||
H1D38_RS04520 | 945792..945965 | + | 174 | 485761819 | hypothetical protein | ||
H1D38_RS04525 (hha) | 946205..946417 | - | 213 | 446375476 | hemolysin expression modulator Hha |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.
Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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