Detailed information of accessory protein


Summary

Accessory protein ID ACP00025 experimental
Type adaptor
Related T6SS (Type) T6SS00790 (Type i1)
Strain Vibrio cholerae V52
Replicon chromosome
Related structure protein VgrG-1
Related effector TseL
Description Tap-1, DUF4123 domain-containing protein.
Reference [1] Unterweger D, Kostiuk B, Ötjengerdes R, et al. Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae. EMBO J. 2015 Aug 13;34(16):2198-210. doi: 10.15252/embj.201591163. Epub 2015 Jul 19. PMID: 26194724
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
External database links

Locus tag (Gene) VCV52_1391 (tap-1)
Coordinates (Strand) 434220..435080 (-)
NCBI ID 446336115
RefSeq NZ_KQ410498
Uniprot ID UPI00005F3639
KEGG ID -
PDB ID -
Pfam domain hit(s)

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Domain
Pfam ID
E-value
Aligned region
DUF4123PF13503.88.3e-1628..140
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-286MATHYCLVENGMEKMLLQWLSEQTSNVYWLADHLTFKQAVANNSGIVFDGTQVVFHGETFAPVMALSPWLVPVSDMVSDIDYECLQQGIFLSCSCPSTELLSHLQSLLIAALEGEEVLFRFYDRQVIVPMLERMDEIEKNQFLGKINQLVVFDSHEKNRLVSFTNTSDAQFTAKKTTWWVIKRHHLEAHENLPLVQANLESWLWRHFPKVMNEYLIQGRDIASMLAPSLSVPEQTLTYRVLSAAIVAVVGAEQLTQPSMIEFLRDYNNEEAQLALHALTRQFELRG


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.9975--


  Protein sequence: 287 a.a.    

>ACP00025 NZ_KQ410498:c435080-434220 [Vibrio cholerae V52]
MATHYCLVENGMEKMLLQWLSEQTSNVYWLADHLTFKQAVANNSGIVFDGTQVVFHGETFAPVMALSPWLVPVSDMVSDI
DYECLQQGIFLSCSCPSTELLSHLQSLLIAALEGEEVLFRFYDRQVIVPMLERMDEIEKNQFLGKINQLVVFDSHEKNRL
VSFTNTSDAQFTAKKTTWWVIKRHHLEAHENLPLVQANLESWLWRHFPKVMNEYLIQGRDIASMLAPSLSVPEQTLTYRV
LSAAIVAVVGAEQLTQPSMIEFLRDYNNEEAQLALHALTRQFELRG*

  Nucleotide sequence: 861 bp    

>ACP00025 NZ_KQ410498:c435080-434220 [Vibrio cholerae V52]
ATGGCAACGCATTATTGCTTAGTGGAAAATGGAATGGAAAAGATGCTTTTACAATGGTTGAGTGAACAGACATCAAACGT
CTATTGGCTTGCTGATCATTTAACGTTTAAACAGGCGGTGGCGAATAACAGTGGAATTGTATTTGATGGTACACAAGTTG
TTTTCCACGGAGAGACCTTTGCCCCTGTGATGGCGTTATCGCCCTGGTTAGTCCCTGTCTCTGATATGGTATCGGATATC
GACTACGAGTGCTTACAACAAGGTATATTCCTAAGTTGCTCCTGTCCCTCCACAGAGTTATTAAGCCATCTCCAAAGCCT
TTTGATTGCAGCACTGGAAGGCGAAGAAGTACTGTTTCGTTTTTATGATAGGCAGGTCATTGTGCCTATGCTTGAACGAA
TGGATGAAATAGAAAAAAATCAGTTCTTAGGTAAGATAAATCAGTTAGTCGTGTTCGATAGCCATGAGAAAAATCGGTTA
GTCTCATTTACCAATACATCAGACGCTCAGTTTACGGCCAAAAAGACAACGTGGTGGGTGATCAAACGACACCATTTGGA
GGCTCATGAGAATTTGCCTCTTGTTCAAGCTAACCTCGAATCTTGGCTATGGCGGCATTTTCCAAAAGTGATGAACGAGT
ACTTAATTCAAGGGCGTGATATCGCTTCCATGCTCGCTCCATCTCTCTCTGTTCCTGAACAAACCTTAACATATCGTGTG
TTAAGTGCCGCTATCGTTGCTGTTGTCGGTGCCGAACAATTGACTCAGCCTAGCATGATTGAATTTCTACGAGACTATAA
CAACGAAGAAGCTCAGCTCGCTCTGCATGCTTTAACTCGTCAATTTGAACTAAGGGGATAA