Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01247  |
| T6SS type | Type i1 |
| Strain | Vibrio parahaemolyticus strain T9109 |
| Replicon (RefSeq) | chromosome (NZ_JTGR01000038) |
| Location | 206703..237535 |
| Function | anti-bacterial |
| Comment | The T9109 T6SS1 was active under warm marine-like conditions, as evident by VgrG1 secretion. |
| References | [1] Fridman CM, Keppel K, Gerlic M, Bosis E, Salomon D. et al (2020) A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors.. Nat Commun. 11(1):1085. [PudMed:32109231] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagA | TagE | TagH | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PO79_RS04510 | 202460..203062 | - | 603 | 527097397 | 2OG-Fe(II) oxygenase | ||
| PO79_RS04515 | 203222..203440 | - | 219 | pseudogene | hypothetical protein | ||
| PO79_RS04520 | 203472..203963 | - | 492 | 835942973 | hypothetical protein | ||
| PO79_RS04525 | 203972..204547 | - | 576 | 835942977 | hypothetical protein | ||
| PO79_RS04530 | 204718..205209 | - | 492 | 835942980 | hypothetical protein | ||
| PO79_RS04535 | 205212..205817 | - | 606 | 491637645 | hypothetical protein | ||
| PO79_RS04540 | 205822..206703 | - | 882 | 491637646 | AHH domain-containing protein | ||
| T6CP015643 | PAAR | PO79_RS04545 | 206703..208226 | - | 1524 | 1159843676 | DUF4150 domain-containing protein |
| T6CP015644 | TssL | PO79_RS04550 (icmH) | 208376..209167 | - | 792 | 491591893 | type IVB secretion system protein IcmH/DotU |
| T6CP015645 | TssK | PO79_RS04555 (tssK) | 209164..210489 | - | 1326 | 491623174 | type VI secretion system baseplate subunit TssK |
| T6CP015646 | TssJ | PO79_RS04560 (tssJ) | 210501..211001 | - | 501 | 499418365 | type VI secretion system lipoprotein TssJ |
| T6CP015647 | TagH | PO79_RS04565 | 210994..212508 | - | 1515 | 835942998 | FHA domain-containing protein |
| PO79_RS04570 | 212518..213117 | - | 600 | 491637654 | hypothetical protein | ||
| T6CP015648 | TagA | PO79_RS04575 | 213637..214932 | + | 1296 | 646710470 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP015649 | TssM | PO79_RS04580 (tssM) | 214954..218343 | + | 3390 | 835943002 | type VI secretion system membrane subunit TssM |
| PO79_RS04585 | 218376..218828 | + | 453 | 491623128 | Lrp/AsnC family transcriptional regulator | ||
| T6CP015650 | TssG | PO79_RS04590 (tssG) | 218892..219890 | - | 999 | 491623152 | type VI secretion system baseplate subunit TssG |
| T6CP015651 | TssF | PO79_RS04595 (tssF) | 219887..221635 | - | 1749 | 491623126 | type VI secretion system baseplate subunit TssF |
| T6CP015652 | TssE | PO79_RS04600 (tssE) | 221646..222056 | - | 411 | 491623044 | type VI secretion system baseplate subunit TssE |
| T6CP015653 | TssC | PO79_RS04605 (tssC) | 222118..223593 | - | 1476 | 491623191 | type VI secretion system contractile sheath large subunit |
| T6CP015654 | TssB | PO79_RS04610 (tssB) | 223602..224108 | - | 507 | 491623049 | type VI secretion system contractile sheath small subunit |
| T6CP015655 | TssA | PO79_RS04615 (tssA) | 224135..225709 | - | 1575 | 659047759 | type VI secretion system protein TssA |
| T6CP015656 | TagE | PO79_RS04620 | 225709..227712 | - | 2004 | 646462483 | protein kinase family protein |
| PO79_RS04625 | 227947..228891 | - | 945 | 639552101 | hypothetical protein | ||
| PO79_RS04630 | 228884..229876 | - | 993 | 505109566 | DUF2169 domain-containing protein | ||
| PO79_RS04635 | 229857..231176 | - | 1320 | 670462303 | hypothetical protein | ||
| PO79_RS04640 | 231254..231739 | - | 486 | 835943030 | hypothetical protein | ||
| T6CP015657 | TssI | PO79_RS04645 (tssI) | 231739..233817 | - | 2079 | 491637679 | type VI secretion system tip protein VgrG |
| T6CP015658 | TssD | PO79_RS04650 | 233890..234408 | - | 519 | 491623110 | Hcp family type VI secretion system effector |
| T6CP015659 | TssH | PO79_RS04655 (tssH) | 234863..237535 | + | 2673 | 545084342 | type VI secretion system ATPase TssH |
| PO79_RS04660 | 237522..239153 | + | 1632 | 835943047 | sigma-54-dependent Fis family transcriptional regulator |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01834 |
PO79_RS05910 (Tme2) | Tme | IMU00353 |
Vibrio parahaemolyticus strain T9109 | chromosome (NZ_JTGR01000043) | 165330..166532 (+) | 835943566 |
| EFF01833 |
PO79_RS04645 (VgrG1) | - | - | Vibrio parahaemolyticus strain T9109 | chromosome (NZ_JTGR01000038) | 231739..233817 (-) | 491637679 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00353 |
PO79_RS05915 (Tmi2) | EFF01834 |
Vibrio parahaemolyticus strain T9109 | chromosome (NZ_JTGR01000043) | 166529..166984 (+) | 646368409 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|