Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS01213 experimental
T6SS type Type i3
Strain Pseudomonas aeruginosa PAK
Replicon (RefSeq) chromosome (NZ_CP020659)
Location 5670794..5696508
Function -
Comment -
References
[1] Aragon IM et al (2015) Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections. Environ Microbiol. doi: 10.1111/1462-2920.12856. [PudMed:25809128]
[2] Marden JN et al (2013) An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 110(37):15055-60. [PudMed:23980177]
[3] Li K et al (2013) SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa. MBio. 4(6):e00419-13. [PudMed:24169572]
[4] Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. et al (2016) Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa.. Front Microbiol. 0.463194444. [PudMed:26973625]
[5] Brencic A et al (2009) Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol. 72(3):612-32. [PudMed:19426209]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTssBTssCTssDTssETssFTssGTssHTssITssJTssKTssM
Number11111112111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
Y880_RS26975 5666463..5667182 - 720 WP_003118568.1 type IV secretion associated ABC transporter ATP-binding protein TagT
Y880_RS26980 5667179..5669371 - 2193 pseudogene protein kinase
Y880_RS26985 5669379..5670107 - 729 WP_003106965.1 serine/threonine phosphatase PppA
Y880_RS26990 (tagF) 5670117..5670797 - 681 WP_003106966.1 type VI secretion system-associated protein TagF
T6CP015346 TssM Y880_RS26995 (tssM) 5670794..5674327 - 3534 WP_016252830.1 type VI secretion system membrane subunit TssM
Y880_RS27000 5674324..5675635 - 1312 pseudogene DotU family type VI secretion system protein
T6CP015347 TssK Y880_RS27005 (tssK) 5675642..5676976 - 1335 WP_003115052.1 type VI secretion system baseplate subunit TssK
T6CP015348 TssJ Y880_RS27010 (tssJ) 5676992..5677456 - 465 WP_003083660.1 type VI secretion system lipoprotein TssJ
Y880_RS27015 (tagH) 5677501..5678748 - 1248 pseudogene type VI secretion system-associated FHA domain protein TagH
Y880_RS27020 (tssA) 5679116..5680145 + 1030 pseudogene type VI secretion system protein TssA
T6CP015349 TssB Y880_RS27025 (tssB) 5680234..5680752 + 519 WP_003083666.1 type VI secretion system contractile sheath small subunit
T6CP015350 TssC Y880_RS27030 (tssC) 5680765..5682261 + 1497 WP_003104973.1 type VI secretion system contractile sheath large subunit
T6CP015351 TssD Y880_RS27035 5682337..5682825 + 489 WP_003083670.1 type VI secretion system receptor/chaperone Hcp
Y880_RS27040 5682993..5683838 + 846 WP_003119488.1 type VI secretion system accessory protein TagJ
T6CP015352 TssE Y880_RS27045 (tssE) 5683840..5684349 + 510 WP_003083674.1 type VI secretion system baseplate subunit TssE
T6CP015353 TssF Y880_RS27050 (tssF) 5684346..5686205 + 1860 WP_033894378.1 type VI secretion system baseplate subunit TssF
T6CP015354 TssG Y880_RS27055 (tssG) 5686169..5687215 + 1047 WP_003104969.1 type VI secretion system baseplate subunit TssG
T6CP015355 TssH Y880_RS27060 (tssH) 5687208..5689916 + 2709 WP_003115056.1 type VI secretion system ATPase TssH
T6CP015356 TssI Y880_RS27065 5689963..5691894 + 1932 WP_003142374.1 type VI secretion system spike protein VgrG1a
Y880_RS27070 5692009..5692293 - 285 WP_003104961.1 hypothetical protein
Y880_RS27075 5692290..5693582 - 1293 WP_003104959.1 PAAR domain-containing protein
Y880_RS27080 5693598..5694032 - 435 WP_003083692.1 DcrB-related protein
T6CP015357 TssI Y880_RS27085 (vgrG) 5694286..5696508 + 2223 WP_016252832.1 type VI secretion system spike protein VgrG1b
Y880_RS27090 5696536..5696988 + 453 WP_004351979.1 hypothetical protein
Y880_RS27095 5696918..5698117 + 1200 WP_079276184.1 DUF2169 domain-containing protein
Y880_RS27100 5698114..5699151 + 1038 WP_003161052.1 3-oxoacyl-ACP synthase
Y880_RS27105 5699152..5700099 + 948 WP_003123791.1 DUF4150 domain-containing protein
Y880_RS27110 5700110..5701024 + 915 WP_003110650.1 hypothetical protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0007 experimental Y880_04683 (pnp) protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 4637120..4639225 (-) 489185761 PA0527.1 (RsmY) (↑); PA3621.1 (RsmZ) (↑)
REG0008 experimental PA0527.1 (RsmY) ncRNA RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NZ_CP020659) 586867..586990 (+) - RsmA (Y880_06257) (↓)
REG0009 experimental PA3621.1 (RsmZ) ncRNA RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NZ_CP020659) 4057543..4057658 (-) - RsmA (Y880_06257) (↓)
REG0010 experimental Y880_06257 (rsmA) protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 6213838..6214644 (-) 510932573 PA4492 mRNA (↑)
REG0011 experimental Y880_05180 (rmsF) protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5147809..5148024 (-) 489186811 tssA1 expression (↑)
REG0012 experimental Y880_02189 (gacA/uvrY) protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0013 experimental Y880_03649 (suhB) protein TCS regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 3616623..3617438 (+) 489183406 Y880_02189 (gacA/uvrY) (↓)
REG0037 experimental Y880_05519 (dgcP) protein c-di-GMP regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5487251..5489266 (-) 489205065 the levels of c-di-GMP (↓)

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector