Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01213  |
| T6SS type | Type i3 |
| Strain | Pseudomonas aeruginosa PAK |
| Replicon (RefSeq) | chromosome (NZ_CP020659) |
| Location | 5670794..5696508 |
| Function | - |
| Comment | - |
| References | [1] Aragon IM et al (2015) Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections. Environ Microbiol. doi: 10.1111/1462-2920.12856. [PudMed:25809128] [2] Marden JN et al (2013) An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 110(37):15055-60. [PudMed:23980177] [3] Li K et al (2013) SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa. MBio. 4(6):e00419-13. [PudMed:24169572] [4] Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. et al (2016) Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa.. Front Microbiol. 0.463194444. [PudMed:26973625] [5] Brencic A et al (2009) Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol. 72(3):612-32. [PudMed:19426209] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| Y880_RS26975 | 5666463..5667182 | - | 720 | WP_003118568.1 | type IV secretion associated ABC transporter ATP-binding protein TagT | ||
| Y880_RS26980 | 5667179..5669371 | - | 2193 | pseudogene | protein kinase | ||
| Y880_RS26985 | 5669379..5670107 | - | 729 | WP_003106965.1 | serine/threonine phosphatase PppA | ||
| Y880_RS26990 (tagF) | 5670117..5670797 | - | 681 | WP_003106966.1 | type VI secretion system-associated protein TagF | ||
| T6CP015346 | TssM | Y880_RS26995 (tssM) | 5670794..5674327 | - | 3534 | WP_016252830.1 | type VI secretion system membrane subunit TssM |
| Y880_RS27000 | 5674324..5675635 | - | 1312 | pseudogene | DotU family type VI secretion system protein | ||
| T6CP015347 | TssK | Y880_RS27005 (tssK) | 5675642..5676976 | - | 1335 | WP_003115052.1 | type VI secretion system baseplate subunit TssK |
| T6CP015348 | TssJ | Y880_RS27010 (tssJ) | 5676992..5677456 | - | 465 | WP_003083660.1 | type VI secretion system lipoprotein TssJ |
| Y880_RS27015 (tagH) | 5677501..5678748 | - | 1248 | pseudogene | type VI secretion system-associated FHA domain protein TagH | ||
| Y880_RS27020 (tssA) | 5679116..5680145 | + | 1030 | pseudogene | type VI secretion system protein TssA | ||
| T6CP015349 | TssB | Y880_RS27025 (tssB) | 5680234..5680752 | + | 519 | WP_003083666.1 | type VI secretion system contractile sheath small subunit |
| T6CP015350 | TssC | Y880_RS27030 (tssC) | 5680765..5682261 | + | 1497 | WP_003104973.1 | type VI secretion system contractile sheath large subunit |
| T6CP015351 | TssD | Y880_RS27035 | 5682337..5682825 | + | 489 | WP_003083670.1 | type VI secretion system receptor/chaperone Hcp |
| Y880_RS27040 | 5682993..5683838 | + | 846 | WP_003119488.1 | type VI secretion system accessory protein TagJ | ||
| T6CP015352 | TssE | Y880_RS27045 (tssE) | 5683840..5684349 | + | 510 | WP_003083674.1 | type VI secretion system baseplate subunit TssE |
| T6CP015353 | TssF | Y880_RS27050 (tssF) | 5684346..5686205 | + | 1860 | WP_033894378.1 | type VI secretion system baseplate subunit TssF |
| T6CP015354 | TssG | Y880_RS27055 (tssG) | 5686169..5687215 | + | 1047 | WP_003104969.1 | type VI secretion system baseplate subunit TssG |
| T6CP015355 | TssH | Y880_RS27060 (tssH) | 5687208..5689916 | + | 2709 | WP_003115056.1 | type VI secretion system ATPase TssH |
| T6CP015356 | TssI | Y880_RS27065 | 5689963..5691894 | + | 1932 | WP_003142374.1 | type VI secretion system spike protein VgrG1a |
| Y880_RS27070 | 5692009..5692293 | - | 285 | WP_003104961.1 | hypothetical protein | ||
| Y880_RS27075 | 5692290..5693582 | - | 1293 | WP_003104959.1 | PAAR domain-containing protein | ||
| Y880_RS27080 | 5693598..5694032 | - | 435 | WP_003083692.1 | DcrB-related protein | ||
| T6CP015357 | TssI | Y880_RS27085 (vgrG) | 5694286..5696508 | + | 2223 | WP_016252832.1 | type VI secretion system spike protein VgrG1b |
| Y880_RS27090 | 5696536..5696988 | + | 453 | WP_004351979.1 | hypothetical protein | ||
| Y880_RS27095 | 5696918..5698117 | + | 1200 | WP_079276184.1 | DUF2169 domain-containing protein | ||
| Y880_RS27100 | 5698114..5699151 | + | 1038 | WP_003161052.1 | 3-oxoacyl-ACP synthase | ||
| Y880_RS27105 | 5699152..5700099 | + | 948 | WP_003123791.1 | DUF4150 domain-containing protein | ||
| Y880_RS27110 | 5700110..5701024 | + | 915 | WP_003110650.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF76647 |
Y880_RS10855 (tse5) | Tse | IMU38220 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2306683..2310636 (-) | WP_016253337.1 |
| EFF76642 |
Y880_RS19070 (tse8) | Tae | IMU38215 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 3986374..3988083 (+) | WP_003101313.1 |
| EFF76643 |
Y880_RS06360 (tse1) | Tae | IMU38216 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 1318816..1319280 (-) | WP_016253554.1 |
| EFF76644 |
Y880_RS10940 (tse2) | Tse | IMU38217 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2330486..2330962 (+) | WP_003119469.1 |
| EFF76645 |
Y880_RS15550 (tse3) | Tge | IMU38218 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 3243308..3244534 (+) | WP_003092026.1 |
| EFF76646 |
Y880_RS11390 (tse4) | Tse | IMU38219 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2409831..2410418 (-) | WP_003099160.1 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU38215 |
Y880_RS19075 (tsi8) | EFF76642 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 3988145..3988471 (+) | WP_003093540.1 |
| IMU38216 |
Y880_RS06365 (tsi1) | EFF76643 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 1319322..1320002 (-) | WP_174243846.1 |
| IMU38217 |
Y880_RS10945 (tsi2) | EFF76644 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2330972..2331205 (+) | WP_003114383.1 |
| IMU38218 |
Y880_RS15555 (tsi3) | EFF76645 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 3244531..3244968 (+) | WP_003113900.1 |
| IMU38219 |
Y880_RS11395 (tsi4) | EFF76646 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2410423..2410860 (-) | WP_003099162.1 |
| IMU38220 |
Y880_RS10850 (tsi5) | EFF76647 |
Pseudomonas aeruginosa PAK | chromosome (NZ_CP020659) | 2306495..2306686 (-) | WP_003090543.1 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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