Detailed information of regulator

Summary

Regulator ID	REG0012
Regulator type	protein
Regulatory pathway (from literatures)	TCS-RR
KEGG pathway (determined by BlastKOALA)	Two-component system (map02020); Biofilm formation - Vibrio cholerae (map05111); Biofilm formation - Pseudomonas aeruginosa (map02025); Biofilm formation - Escherichia coli (map02026)
Related T6SS	T6SS01211 (Type i1); T6SS01212 (Type i4a); T6SS01213 (Type i3)
Strain	Pseudomonas aeruginosa PAK
Replicon	chromosome
Sequence	Protein sequence (215 a.a.); Nucleotide sequence (645 bp)
Description	Deletion of gacA or rsmY/rsmZ reduced the level of Hcp1 in the suhB mutant background.
Reference	[1] Li K, Xu C, Jin Y, et al. SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa. mBio. 2013 Oct 29;4(6):e00419-13. doi: 10.1128/mBio.00419-13. PMID: 24169572

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External database links

Locus tag (Gene)	Y880_02189 (gacA/uvrY)
Coordinates (Strand)	2199690..2200334 (-)
NCBI ID	510933056
RefSeq	NZ_CP020659
Uniprot ID	UPI00033DBBF0
KEGG ID	-
KEGG pathway (determined by BlastKOALA)	map02020; map05111; map02025; map02026
PDB ID	-

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  Target

Target	Regulation (↓/↑)	Target sequence
hcp expression	↓	-

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Pfam domain hit(s) of regulator

Domain	Pfam ID	E-value	Aligned region
Response_reg	PF00072.26	1.7e-27	4..116
GerE	PF00196.21	1.2e-14	148..204

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-214	VIKVLVVDDHDLVRTGITRMLADIEGLQVVGQADCGEDCLKLARELKSDVVLMDVKMPGIGGLEATRKLLRSQPDIKVVVVTVCEEDPFPTRLMQAGAAGYMTKGAGLEEMVQAIRQVFAGQRYISPQIAQQLALKSFQPQQHDSPFDSLSEREIQIALMIANCHKVQSISDKLCLSPKTVNTYRYRIFEKLSITSDVELALLAVRHGMVDAAS

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9948	-	-

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  Protein sequence of regulator: 215 a.a.    .Download


  Nucleotide sequence of regulator: 645 bp    .Download