Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01212  |
| T6SS type | Type i4a |
| Strain | Pseudomonas aeruginosa PAK |
| Replicon (RefSeq) | chromosome (NZ_CP020659) |
| Location | 1913764..1933758 |
| Function | - |
| Comment | - |
| References | [1] Aragon IM et al (2015) Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections. Environ Microbiol. doi: 10.1111/1462-2920.12856. [PudMed:25809128] [2] Marden JN et al (2013) An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 110(37):15055-60. [PudMed:23980177] [3] Li K et al (2013) SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa. MBio. 4(6):e00419-13. [PudMed:24169572] [4] Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. et al (2016) Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa.. Front Microbiol. 0.463194444. [PudMed:26973625] [5] Brencic A et al (2009) Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol. 72(3):612-32. [PudMed:19426209] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | IglG | TssA | TssB | TssC | TssD | TssE | TssG | TssH | TssI | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| Y880_RS09120 | 1908994..1910162 | - | 1169 | pseudogene | acyl-CoA dehydrogenase family protein | ||
| Y880_RS09125 (ssuD) | 1910192..1911337 | - | 1146 | WP_003104713.1 | FMNH2-dependent alkanesulfonate monooxygenase | ||
| Y880_RS09130 (msuE) | 1911347..1911907 | - | 561 | WP_003089470.1 | FMN reductase | ||
| Y880_RS09135 | 1912067..1912333 | - | 267 | WP_003104712.1 | hypothetical protein | ||
| Y880_RS09140 | 1912569..1913654 | - | 1086 | WP_016253426.1 | sigma-54-dependent transcriptional regulator | ||
| T6CP015334 | TssA | Y880_RS09145 (tssA) | 1913764..1914864 | - | 1101 | WP_016253425.1 | type VI secretion system protein TssA |
| T6CP015335 | TssM | Y880_RS09150 | 1914861..1918676 | - | 3816 | WP_016253424.1 | hypothetical protein |
| T6CP015336 | TssL | Y880_RS09155 | 1918673..1918825 | - | 153 | WP_020750951.1 | hypothetical protein |
| Y880_RS09160 (tssK) | 1918878..1919980 | - | 1103 | WP_033893990.1 | type VI secretion system baseplate subunit TssK | ||
| Y880_RS09165 | 1920040..1920516 | - | 477 | WP_003089492.1 | hypothetical protein | ||
| T6CP015338 | TssB | Y880_RS09170 (tssB) | 1920724..1921269 | + | 546 | WP_003089493.1 | type VI secretion system contractile sheath small subunit |
| T6CP015339 | TssC | Y880_RS09175 (tssC) | 1921292..1922776 | + | 1485 | WP_016253422.1 | type VI secretion system contractile sheath large subunit |
| T6CP015340 | TssD | Y880_RS09180 | 1922850..1923347 | + | 498 | WP_003089495.1 | type VI secretion system tube protein Hcp |
| T6CP015341 | TssE | Y880_RS09185 (tssE) | 1923360..1923785 | + | 426 | WP_003122696.1 | type VI secretion system baseplate subunit TssE |
| Y880_RS09190 (tssF) | 1923769..1925431 | + | 1663 | pseudogene | type VI secretion system baseplate subunit TssF | ||
| T6CP015342 | TssG | Y880_RS09195 (tssG) | 1925395..1926411 | + | 1017 | WP_003124579.1 | type VI secretion system baseplate subunit TssG |
| T6CP015343 | TssH | Y880_RS09200 (tssH) | 1926413..1928962 | + | 2550 | WP_016253421.1 | type VI secretion system ATPase TssH |
| Y880_RS09205 | 1929053..1929928 | + | 876 | WP_003116944.1 | hypothetical protein | ||
| Y880_RS09210 | 1929998..1930783 | + | 786 | WP_003116945.1 | hypothetical protein | ||
| T6CP015344 | TssI | Y880_RS09215 (tssI) | 1930790..1932793 | + | 2004 | WP_016253420.1 | type VI secretion system tip protein VgrG |
| Y880_RS09220 | 1932804..1933340 | + | 537 | WP_003114514.1 | toxin-antitoxin system YwqK family antitoxin | ||
| T6CP015345 | IglG | Y880_RS09225 | 1933363..1933758 | - | 396 | WP_003089513.1 | DUF4280 domain-containing protein |
| Y880_RS09230 | 1934035..1934676 | + | 642 | WP_003110901.1 | response regulator transcription factor | ||
| Y880_RS09235 | 1934877..1936082 | + | 1206 | WP_016253419.1 | ABC transporter substrate-binding protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|