Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00926  |
| T6SS type | Type iii |
| Strain | Bacteroides fragilis 638R |
| Replicon (RefSeq) | chromosome (NC_016776) |
| Location | 2330059..2352459 |
| Function | anti-bacterial |
| Comment | T6SS is functional in the mammalian gut and necessary for antagonism and protection. |
| References | [1] Chatzidaki-Livanis M, Geva-Zatorsky N, Comstock LE et al (2016) Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species. Proc Natl Acad Sci U S A. 113(13):3627-32. [PudMed:26951680] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssN | TssO | TssP |
| Number | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BF638R_RS09250 | 2327276..2327644 | - | 369 | WP_008768461.1 | hypothetical protein | ||
| BF638R_RS09255 | 2327685..2330057 | - | 2373 | WP_014298723.1 | type VI secretion system protein TssR | ||
| T6CP011289 | TssP | BF638R_RS09260 | 2330059..2330952 | - | 894 | WP_008768463.1 | PKD domain-containing protein |
| T6CP011290 | TssO | BF638R_RS09265 | 2330949..2331476 | - | 528 | WP_008768464.1 | type VI secretion system transmembrane protein TssO |
| T6CP011291 | TssO | BF638R_RS09270 | 2331489..2331992 | - | 504 | WP_005787050.1 | hypothetical protein |
| T6CP011292 | TssG | BF638R_RS09275 | 2331998..2332954 | - | 957 | WP_008768465.1 | type VI secretion system baseplate subunit TssG |
| T6CP011293 | TssK | BF638R_RS09280 | 2332956..2334098 | - | 1143 | WP_008768466.1 | hypothetical protein |
| T6CP011294 | TssN | BF638R_RS09285 | 2334126..2334974 | - | 849 | WP_008768467.1 | TssN family type VI secretion system protein |
| BF638R_RS09290 | 2335034..2336050 | - | 1017 | WP_014298724.1 | hypothetical protein | ||
| BF638R_RS09295 | 2336050..2339019 | - | 2970 | WP_014298725.1 | hypothetical protein | ||
| T6CP012412 | PAAR | BF638R_RS09300 | 2339030..2339716 | - | 687 | WP_008768470.1 | PAAR domain-containing protein |
| T6CP011295 | TssI | BF638R_RS09305 | 2339735..2341585 | - | 1851 | WP_008768471.1 | hypothetical protein |
| T6CP011296 | TssF | BF638R_RS09310 | 2341611..2343428 | - | 1818 | WP_008768472.1 | type VI secretion system baseplate subunit TssF |
| T6CP011297 | TssE | BF638R_RS09315 | 2343459..2343899 | - | 441 | WP_008768473.1 | GPW/gp25 family protein |
| BF638R_RS09320 | 2343896..2344354 | - | 459 | WP_005787085.1 | DUF5456 family protein | ||
| T6CP011298 | TssD | BF638R_RS09325 | 2344359..2344778 | - | 420 | WP_005794665.1 | hypothetical protein |
| T6CP011299 | TssD | BF638R_RS09330 | 2344781..2345188 | - | 408 | WP_005794664.1 | hypothetical protein |
| BF638R_RS09335 | 2345381..2345782 | - | 402 | WP_005794661.1 | hypothetical protein | ||
| BF638R_RS09340 | 2345779..2346774 | - | 996 | WP_008768475.1 | hypothetical protein | ||
| T6CP011300 | TssD | BF638R_RS09345 | 2346787..2347191 | - | 405 | WP_005794657.1 | hypothetical protein |
| T6CP011301 | TssD | BF638R_RS09350 | 2347197..2347625 | - | 429 | WP_008768476.1 | hypothetical protein |
| T6CP011302 | TssH | BF638R_RS09355 | 2347641..2350124 | - | 2484 | WP_005794654.1 | ATP-dependent Clp protease ATP-binding subunit |
| T6CP011303 | TssC | BF638R_RS09360 | 2350137..2351516 | - | 1380 | WP_005787102.1 | DUF5458 family protein |
| T6CP011304 | TssB | BF638R_RS09365 | 2351532..2351981 | - | 450 | WP_005787103.1 | hypothetical protein |
| T6CP011305 | TssD | BF638R_RS09370 | 2352070..2352459 | - | 390 | WP_005787106.1 | hypothetical protein |
| BF638R_RS09375 | 2352900..2353640 | - | 741 | WP_010992806.1 | TetR/AcrR family transcriptional regulator | ||
| BF638R_RS09380 | 2353988..2355259 | + | 1272 | WP_008768478.1 | pyridoxal phosphate-dependent aminotransferase family protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01497 |
Bf638R_1979 (Bfe2) | Tme | IMU00312 |
Bacteroides fragilis 638R | chromosome (NC_016776) | 2336050..2339019 (-) | 504064731 |
| EFF01451 |
BF638R_1988 | Tse | IMU00311 |
Bacteroides fragilis 638R | chromosome (NC_016776) | 2345779..2346774 (-) | 301162963 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00311 |
Bf638R_1987 (Bfi1) | EFF01451 |
Bacteroides fragilis 638R | chromosome (NC_016776) | 2345381..2345809 (-) | 496043967 |
| IMU00312 |
Bf638R_1978 (Bfi2) | EFF01497 |
Bacteroides fragilis 638R | chromosome (NC_016776) | 2335034..2336062 (-) | 499516015 |
| IMU00362 |
BF638R_RS09610 (i7) | - | Bacteroides fragilis 638R | chromosome (NC_016776) | 2402650..2403639 (+) | 504064765 |
| IMU00363 |
BF638R_RS09665 (i6) | - | Bacteroides fragilis 638R | chromosome (NC_016776) | 2411584..2412630 (+) | 504064776 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|