Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01295  |
| T6SS type | Type i3 |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (GenBank) | chromosome II (CP009537) |
| Location | 2499073..2525393 |
| Function | - |
| Comment | The LD50 values for the Δhcp2 through Δhcp6 mutants were indistinguishable from that of the wild type, suggesting that T6SS-2, T6SS-3, T6SS-4, T6SS-5, and T6SS-6 are not required for virulence in this animal model of infection. |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| AQ15_5498 | 2494785..2495474 | - | 690 | 772957374 | CDP-alcohol phosphatidyltransferase family protein | ||
| AQ15_5499 | 2495839..2497353 | + | 1515 | 772957312 | succinate CoA transferase family protein | ||
| T6CP013092 | TssA | AQ15_5500 | 2499073..2500011 | + | 939 | 772957581 | hypothetical protein |
| T6CP013093 | TssB | AQ15_5501 | 2500045..2500593 | + | 549 | 772956950 | hypothetical protein |
| T6CP013094 | TssC | AQ15_5502 | 2500596..2502101 | + | 1506 | 772956927 | hypothetical protein |
| T6CP013095 | TssD | AQ15_5503 | 2502245..2502772 | + | 528 | 772958313 | hypothetical protein |
| T6CP013096 | TssE | AQ15_5504 | 2502852..2503283 | + | 432 | 772956961 | 25-like lysozyme family protein |
| T6CP013097 | TssF | AQ15_5505 | 2503297..2505159 | + | 1863 | 772956941 | hypothetical protein |
| T6CP013098 | TssG | AQ15_5506 | 2505156..2506145 | + | 990 | 772958337 | hypothetical protein |
| T6CP013099 | TssH | AQ15_5507 (clpV) | 2506148..2509018 | + | 2871 | 772956767 | type VI secretion ATPase, ClpV1 family |
| T6CP013100 | TssI | AQ15_5508 | 2509009..2511300 | + | 2292 | 772958388 | Rhs element Vgr family protein |
| T6CP013101 | TssI | AQ15_5509 | 2511466..2513754 | + | 2289 | 772957586 | Rhs element Vgr family protein |
| AQ15_5510 | 2513758..2515974 | + | 2217 | 772958213 | pentapeptide repeats family protein | ||
| AQ15_5511 | 2515974..2517044 | + | 1071 | 772958375 | pentapeptide repeats family protein | ||
| AQ15_5512 | 2517047..2517763 | + | 717 | 772957188 | hypothetical protein | ||
| AQ15_5513 | 2517806..2518195 | + | 390 | 772957885 | hypothetical protein | ||
| AQ15_5514 | 2518213..2518794 | + | 582 | 772958343 | type VI secretion lipofamily protein | ||
| T6CP013102 | TssK | AQ15_5515 | 2518791..2520152 | + | 1362 | 772957881 | hypothetical protein |
| T6CP013103 | TssL | AQ15_5516 | 2520235..2521893 | + | 1659 | 772957888 | type IV/VI secretion system, DotU family domain protein |
| T6CP013104 | TssM | AQ15_5517 | 2521890..2525393 | + | 3504 | 772957664 | intracellular multiplication and macrophage-killing family protein |
| AQ15_5518 | 2525452..2525811 | + | 360 | 772958036 | hypothetical protein | ||
| AQ15_5519 | 2525966..2526259 | + | 294 | 772956944 | hypothetical protein | ||
| AQ15_5520 | 2526484..2526855 | + | 372 | 772956521 | hypothetical protein | ||
| AQ15_5521 | 2527406..2528305 | + | 900 | 772956775 | alpha/beta hydrolase family protein | ||
| AQ15_5522 | 2528527..2529846 | + | 1320 | 772957018 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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