Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01033  |
| T6SS type | Type i3 |
| Strain | Serratia sp. FS14 |
| Replicon (RefSeq) | chromosome (NZ_CP005927) |
| Location | 2830818..2854234 |
| Function | - |
| Comment | Hcp2 protein secretion is dependent on T6SS in FS14. |
| References | [1] Li P, Xu D, Ma T, Wang D, Li W, He J, Ran T, Wang W. et al (2018) Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism.. Biochem J. 475(13):2209-2224. [PudMed:29858276] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| L085_RS12845 | 2825943..2826755 | + | 813 | WP_033643667.1 | helix-turn-helix domain-containing protein | ||
| L085_RS12850 | 2826850..2827482 | + | 633 | WP_044030907.1 | DNA-binding protein | ||
| L085_RS12855 | 2827766..2828728 | + | 963 | WP_044030908.1 | hypothetical protein | ||
| L085_RS12860 | 2828776..2829210 | - | 435 | WP_044030909.1 | DoxX family protein | ||
| T6CP013388 | TssA | L085_RS12865 | 2830818..2831783 | + | 966 | WP_004935378.1 | ImpA family type VI secretion system protein |
| T6CP013389 | TssB | L085_RS12870 (tssB) | 2831808..2832365 | + | 558 | WP_004935376.1 | type VI secretion system contractile sheath small subunit |
| T6CP013390 | TssC | L085_RS12875 (tssC) | 2832362..2833888 | + | 1527 | WP_004935371.1 | type VI secretion system contractile sheath large subunit |
| T6CP013391 | TssD | L085_RS12880 | 2834120..2834644 | + | 525 | WP_004935369.1 | type VI secretion system tube protein Hcp |
| T6CP013392 | TssE | L085_RS12885 | 2834726..2835172 | + | 447 | WP_015378391.1 | GPW/gp25 family protein |
| T6CP013393 | TssF | L085_RS12890 (tssF) | 2835184..2837025 | + | 1842 | WP_015378390.1 | type VI secretion system baseplate subunit TssF |
| T6CP013394 | TssG | L085_RS12895 (tssG) | 2837018..2838046 | + | 1029 | WP_004935359.1 | type VI secretion system baseplate subunit TssG |
| T6CP013395 | TssH | L085_RS12900 (tssH) | 2838063..2840648 | + | 2586 | WP_021505820.1 | type VI secretion system ATPase TssH |
| T6CP013396 | TssI | L085_RS12905 (vgrG) | 2840713..2842974 | + | 2262 | WP_004935351.1 | type VI secretion system tip protein VgrG |
| L085_RS12910 | 2842987..2845212 | + | 2226 | WP_044030910.1 | DUF2169 domain-containing protein | ||
| L085_RS12915 | 2845196..2846356 | + | 1161 | WP_044032033.1 | pentapeptide repeat-containing protein | ||
| L085_RS12920 | 2846349..2846963 | + | 615 | WP_021505818.1 | DUF3540 domain-containing protein | ||
| L085_RS12925 | 2846970..2847335 | + | 366 | WP_004935338.1 | DUF4150 domain-containing protein | ||
| T6CP013397 | TssJ | L085_RS12930 | 2847345..2847851 | + | 507 | WP_004935335.1 | type VI secretion lipoprotein TssJ |
| T6CP013398 | TssK | L085_RS12935 (tssK) | 2847853..2849211 | + | 1359 | WP_044030911.1 | type VI secretion system baseplate subunit TssK |
| T6CP013399 | TssL | L085_RS12940 | 2849208..2850719 | + | 1512 | WP_044030912.1 | type IVB secretion system protein IcmH/DotU |
| T6CP013400 | TssM | L085_RS12945 (tssM) | 2850755..2854234 | + | 3480 | WP_044030913.1 | type VI secretion system membrane subunit TssM |
| L085_RS12950 | 2854260..2854613 | + | 354 | WP_004935323.1 | hypothetical protein | ||
| L085_RS12955 | 2854879..2855106 | - | 228 | WP_004935320.1 | hypothetical protein | ||
| L085_RS12960 | 2855351..2855641 | + | 291 | WP_004935318.1 | hypothetical protein | ||
| L085_RS12965 | 2856346..2856921 | + | 576 | WP_004935315.1 | LuxR family transcriptional regulator | ||
| L085_RS12970 | 2857030..2857899 | + | 870 | WP_015378383.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0006 |
L085_RS13655 (ppka) | protein | Tpp | Serratia sp. FS14 | chromosome (NZ_CP005927) | 3028273..3029718 (-) | 763151328 | Unknown (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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