Regulators of regulatory pathway: Tpp

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0006 experimental L085_RS13655 (ppka) T6SS01033 experimental protein Tpp Serratia sp. FS14 chromosome (NZ_CP005927) 3028273..3029718 (-) 763151328 Unknown (↓)
REG0014 experimental SMDB11_2275 (PpKA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2399154..2400599 (+) 560174118 SMDB11_2267 (FHA) (↓)
REG0015 experimental SMDB11_2268 (PppA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2390232..2391005 (+) 560174111 SMDB11_2267 (FHA) (↑)
REG0016 experimental SMDB11_2269 (RtkS) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2391034..2392020 (+) 560174112 SMDB11_2275 (PpKA) (↓)
REG0017 experimental SMDB11_2256 (TagF) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2380702..2381421 (+) 560174099 Unknown (↑)
REG0042 experimental PA0075 (PppA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90106..90834 (-) 15595273 PA0081 (Fha-1/TagH) (↑)
REG0043 experimental PA0074 (PpkA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 87000..90098 (-) 15595272 PA0081 (Fha-1/TagH) (↓)
REG0047 experimental PA0072 (TagS) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 85085..86284 (-) 15595270 PA0073 (TagT) (↓)
REG0048 experimental PA0070 (TagQ) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 82404..83318 (-) 15595268 PA0071 (tagR) (↓)
REG0049 experimental PA0073 (TagT) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 86284..87003 (-) 15595271 PA0072 (TagS) (↓)
REG0052 experimental PA0071 (tagR) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 83380..85092 (-) 15595269 PA0074 (PpkA) (↓)
REG0056 experimental PA0076 (TagF) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90844..91524 (-) 15595274 hcp1 (PA0086) secretion (↑)
REG0057 experimental PA0081 (Fha-1/TagH) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 98263..99756 (-) 15595279 Unknown (↓); clpV (↓)
REG0077 experimental Atu4335 (Fha/TagH) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1467064..1468263 (-) 499280697 Unknown (↓)
REG0078 experimental Atu4330 (PpkA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1458366..1459271 (-) 737274050 Unknown (↓)
REG0079 experimental Atu4331 (TagF-PppA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1459258..1460673 (-) 159186120 Fha (Atu4335) (↑)
REG0092 experimental PFL_RS30815 (pppA) T6SS00035 experimental protein Tpp Pseudomonas protegens Pf-5 chromosome (NC_004129) 6902924..6903658 (-) 499376669 Hcp secretion (↑)
REG0257 experimental VEPGS_0614 (PppA) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 15765..16880 (+) 225382180 LuxR (↓)
REG0258 experimental VEPGS_0606 (PpkA2) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 3227..5377 (-) 225382172 LuxR (↓); VEPGS_0610 (DotU2) (↓)
REG0259 experimental VEPGS_0607 (Fha2) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 5690..6775 (+) 225382173 VEPGS_0610 (DotU2) (↓)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0348 experimental SMDB11_2275 (PpkA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2399154..2400599 (+) 560174118 SMDB11_2267/SMA2267 (Fha) (↓); SMDB11_2267/SMA2267 (Fha) (↑)
REG0349 experimental SMDB11_2267 (Fha) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2388490..2390232 (+) 560174110 Unknown (↓)
REG0376 experimental PA3648 (bamA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4085062..4087455 (-) NP_252338.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0377 experimental PA0595 (lptD) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 653753..656527 (-) NP_249286.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0378 experimental PA0972 (tolB) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1056049..1057347 (+) NP_249663.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0006 experimental L085_RS13655 (ppka) T6SS01033 experimental protein Tpp Serratia sp. FS14 chromosome (NZ_CP005927) 3028273..3029718 (-) 763151328 Unknown (↓)
REG0014 experimental SMDB11_2275 (PpKA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2399154..2400599 (+) 560174118 SMDB11_2267 (FHA) (↓)
REG0015 experimental SMDB11_2268 (PppA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2390232..2391005 (+) 560174111 SMDB11_2267 (FHA) (↑)
REG0016 experimental SMDB11_2269 (RtkS) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2391034..2392020 (+) 560174112 SMDB11_2275 (PpKA) (↓)
REG0017 experimental SMDB11_2256 (TagF) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2380702..2381421 (+) 560174099 Unknown (↑)
REG0042 experimental PA0075 (PppA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90106..90834 (-) 15595273 PA0081 (Fha-1/TagH) (↑)
REG0043 experimental PA0074 (PpkA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 87000..90098 (-) 15595272 PA0081 (Fha-1/TagH) (↓)
REG0047 experimental PA0072 (TagS) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 85085..86284 (-) 15595270 PA0073 (TagT) (↓)
REG0048 experimental PA0070 (TagQ) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 82404..83318 (-) 15595268 PA0071 (tagR) (↓)
REG0049 experimental PA0073 (TagT) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 86284..87003 (-) 15595271 PA0072 (TagS) (↓)
REG0052 experimental PA0071 (tagR) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 83380..85092 (-) 15595269 PA0074 (PpkA) (↓)
REG0056 experimental PA0076 (TagF) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 90844..91524 (-) 15595274 hcp1 (PA0086) secretion (↑)
REG0057 experimental PA0081 (Fha-1/TagH) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 98263..99756 (-) 15595279 Unknown (↓); clpV (↓)
REG0077 experimental Atu4335 (Fha/TagH) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1467064..1468263 (-) 499280697 Unknown (↓)
REG0078 experimental Atu4330 (PpkA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1458366..1459271 (-) 737274050 Unknown (↓)
REG0079 experimental Atu4331 (TagF-PppA) T6SS00016 experimental protein Tpp Agrobacterium fabrum str. C58 chromosome (NC_003063) 1459258..1460673 (-) 159186120 Fha (Atu4335) (↑)
REG0092 experimental PFL_RS30815 (pppA) T6SS00035 experimental protein Tpp Pseudomonas protegens Pf-5 chromosome (NC_004129) 6902924..6903658 (-) 499376669 Hcp secretion (↑)
REG0257 experimental VEPGS_0614 (PppA) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 15765..16880 (+) 225382180 LuxR (↓)
REG0258 experimental VEPGS_0606 (PpkA2) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 3227..5377 (-) 225382172 LuxR (↓); VEPGS_0610 (DotU2) (↓)
REG0259 experimental VEPGS_0607 (Fha2) T6SS00794 experimental protein Tpp Vibrio alginolyticus strain EPJS chromosome (FJ790777) 5690..6775 (+) 225382173 VEPGS_0610 (DotU2) (↓)
REG0264 experimental VEPGS_0621 (pppA) T6SS00793 experimental protein Tpp; QS regulatory pathway Vibrio alginolyticus strain EPJS chromosome (FJ790777) 23577..24245 (+) 225382187 Unknown (↑); T6SS1 transcript (↑); hcp1 transcript (↓)
REG0348 experimental SMDB11_2275 (PpkA) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2399154..2400599 (+) 560174118 SMDB11_2267/SMA2267 (Fha) (↓); SMDB11_2267/SMA2267 (Fha) (↑)
REG0349 experimental SMDB11_2267 (Fha) T6SS00929 experimental protein Tpp Serratia marcescens subsp. marcescens Db11 chromosome (HG326223) 2388490..2390232 (+) 560174110 Unknown (↓)
REG0376 experimental PA3648 (bamA) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 4085062..4087455 (-) NP_252338.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0377 experimental PA0595 (lptD) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 653753..656527 (-) NP_249286.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)
REG0378 experimental PA0972 (tolB) T6SS00003 experimental protein Tpp Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 1056049..1057347 (+) NP_249663.1 ClpV-GFP foci accumulate; H1-T6SS transcript (↑)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)