Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00929  |
| T6SS type | Type i3 |
| Strain | Serratia marcescens subsp. marcescens Db11 |
| Replicon (GenBank) | chromosome I (HG326223) |
| Location | 2365124..2402670 |
| Function | anti-bacterial |
| Comment | Killing of E. coli, P. fluorescens, Enterobacter cloacae, another strain of S. marcescens and susceptible mutants of Db10. |
| References | [1] Heymann JB et al (2013) Three-dimensional structure of the toxin-delivery particle antifeeding prophage of Serratia entomophila. J Biol Chem. 288(35):25276-84. [PudMed:23857636] [2] Srikannathasan V et al (2013) Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. Acta Crystallogr D Biol Crystallogr. 69(Pt 12):2468-82. [PudMed:24311588] [3] Rao VA et al (2011) The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system. Acta Crystallogr D Biol Crystallogr. 67(Pt 12):1065-72. [PudMed:22120744] [4] Fritsch MJ et al (2013) Proteomic identification of novel secreted anti-bacterial toxins of the Serratia marcescens Type VI secretion system. Mol Cell Proteomics. 12(10):2735-2749. [PudMed:23842002] [5] English G et al (2012) New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens. Mol Microbiol. 86(4):921-36. [PudMed:22957938] [6] Murdoch SL et al (2011) The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors. J Bacteriol. 193(21):6057-69. [PudMed:21890705] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| SMDB11_2239 (cnu) | 2360950..2361165 | + | 216 | CDG12814.1 | OriC-binding nucleoid-associated protein | ||
| SMDB11_2240 (uspC) | 2361363..2361782 | + | 420 | CDG12815.1 | universal stress protein | ||
| SMDB11_2241 | 2361868..2362899 | + | 1032 | CDG12816.1 | putative zinc-binding alcohol dehydrogenase | ||
| SMDB11_2242 (pcp) | 2362934..2363581 | - | 648 | CDG12817.1 | pyrrolidone-carboxylate peptidase | ||
| SMDB11_2243 | 2363679..2364611 | + | 933 | CDG12818.1 | LysR-family transcriptional regulator | ||
| T6CP012947 | TssI | SMDB11_2244 | 2365103..2367463 | + | 2361 | CDG12819.1 | type VI secretion system, effector protein VgrG-like |
| SMDB11_2245 | 2367474..2367863 | + | 390 | CDG12820.1 | hypothetical protein | ||
| SMDB11_2246 | 2367965..2368465 | + | 501 | CDG12821.1 | hypothetical protein | ||
| SMDB11_2247 | 2368637..2371189 | + | 2553 | CDG12822.1 | pentapeptide repeat-containing protein | ||
| SMDB11_2248 | 2371186..2372253 | + | 1068 | CDG12823.1 | pentapeptide repeat-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00316 | SMDB11_0928 | EFF01501 | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 972883..973656 (+) | 560172776 |
| IMU00318 | SMDB11_0929 | EFF01501 | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 973746..974489 (+) | 560172777 |
| IMU00319 | SMDB11_2278A (RhsI1) | EFF01500 | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 2407591..2408079 (+) | 560174122 |
| IMU00320 | SMDB11_1611 (RhsI2) | EFF01499 | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 1693944..1694432 (+) | 560173454 |
| IMU00354 | SMDB11_0809 | EFF01836 | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 838572..838787 (-) | 560172662 |
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00028 | SMDB11_4101 (dsbA1) | chaperone | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 4377737..4378360 (-) | 560175924 | SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269 | SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2) |
| ACP00029 | SMDB11_0239 (dsbA2) | chaperone | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 265001..265642 (+) | 560172104 | SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269 | SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2) |
| ACP00030 | SMDB11_1609 (eagR2) | adaptor | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 1689187..1689618 (+) | 560173452 | SMDB11_2276 (VgrG2b) | SMDB11_1610 (Rhs2) |
| ACP00031 | SMDB11_2245 (eagR1) | adaptor | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 2367474..2367863 (+) | 560174088 | SMDB11_2276 (VgrG2b) | SMDB11_2278 (Rhs1) |
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