Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00929 ![]() |
T6SS type | Type i3 |
Strain | Serratia marcescens subsp. marcescens Db11 |
Replicon (GenBank) | chromosome I (HG326223) |
Location | 2365124..2402670 |
Function | anti-bacterial |
Comment | Killing of E. coli, P. fluorescens, Enterobacter cloacae, another strain of S. marcescens and susceptible mutants of Db10. |
References | [1] Heymann JB et al (2013) Three-dimensional structure of the toxin-delivery particle antifeeding prophage of Serratia entomophila. J Biol Chem. 288(35):25276-84. [PudMed:23857636] [2] Srikannathasan V et al (2013) Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. Acta Crystallogr D Biol Crystallogr. 69(Pt 12):2468-82. [PudMed:24311588] [3] Rao VA et al (2011) The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system. Acta Crystallogr D Biol Crystallogr. 67(Pt 12):1065-72. [PudMed:22120744] [4] Fritsch MJ et al (2013) Proteomic identification of novel secreted anti-bacterial toxins of the Serratia marcescens Type VI secretion system. Mol Cell Proteomics. 12(10):2735-2749. [PudMed:23842002] [5] English G et al (2012) New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens. Mol Microbiol. 86(4):921-36. [PudMed:22957938] [6] Murdoch SL et al (2011) The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors. J Bacteriol. 193(21):6057-69. [PudMed:21890705] |

T6SS components and genome coordinates
Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |

Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
SMDB11_2239 (cnu) | 2360950..2361165 | + | 216 | CDG12814.1 | OriC-binding nucleoid-associated protein | ||
SMDB11_2240 (uspC) | 2361363..2361782 | + | 420 | CDG12815.1 | universal stress protein | ||
SMDB11_2241 | 2361868..2362899 | + | 1032 | CDG12816.1 | putative zinc-binding alcohol dehydrogenase | ||
SMDB11_2242 (pcp) | 2362934..2363581 | - | 648 | CDG12817.1 | pyrrolidone-carboxylate peptidase | ||
SMDB11_2243 | 2363679..2364611 | + | 933 | CDG12818.1 | LysR-family transcriptional regulator | ||
T6CP012947 | TssI | SMDB11_2244 | 2365103..2367463 | + | 2361 | CDG12819.1 | type VI secretion system, effector protein VgrG-like |
SMDB11_2245 | 2367474..2367863 | + | 390 | CDG12820.1 | hypothetical protein | ||
SMDB11_2246 | 2367965..2368465 | + | 501 | CDG12821.1 | hypothetical protein | ||
SMDB11_2247 | 2368637..2371189 | + | 2553 | CDG12822.1 | pentapeptide repeat-containing protein | ||
SMDB11_2248 | 2371186..2372253 | + | 1068 | CDG12823.1 | pentapeptide repeat-containing protein | ||
SMDB11_2249 | 2372284..2372919 | + | 636 | CDG12824.1 | hypothetical protein | ||
SMDB11_2250 | 2372936..2373328 | + | 393 | CDG12825.1 | hypothetical protein | ||
SMDB11_2251 | 2373377..2373877 | + | 501 | CDG12826.1 | hypothetical protein | ||
T6CP012948 | TssJ | SMDB11_2252 | 2373907..2374437 | + | 531 | CDG12827.1 | type VI secretion system-associated protein,SciN-like |
T6CP012949 | TssK | SMDB11_2253 | 2374478..2375824 | + | 1347 | CDG12828.1 | type VI secretion system-associated protein |
T6CP012950 | TssL | SMDB11_2254 | 2375828..2377048 | + | 1221 | CDG12829.1 | type VI secretion system-associated protein |
T6CP012951 | TssM | SMDB11_2255 | 2377048..2380683 | + | 3636 | CDG12830.1 | type VI secretion system-associated protein,IcmF-like |
SMDB11_2256 | 2380702..2381421 | + | 720 | CDG12831.1 | type VI secretion system-associated protein | ||
T6CP012952 | TssA | SMDB11_2257 | 2381445..2382476 | + | 1032 | CDG12832.1 | type VI secretion system-associated protein |
T6CP012953 | TssB | SMDB11_2258 | 2382597..2383133 | + | 537 | CDG12833.1 | type VI secretion system-associated protein |
T6CP012954 | TssC | SMDB11_2259 | 2383137..2384642 | + | 1506 | CDG12834.1 | type VI secretion system-associated protein |
SMDB11_2260 | 2384710..2385093 | + | 384 | CDG12835.1 | hypothetical protein | ||
SMDB11_2261 | 2385090..2385581 | + | 492 | CDG12836.1 | hypothetical protein | ||
SMDB11_2262 | 2385581..2386036 | + | 456 | CDG12837.1 | hypothetical protein | ||
T6CP012955 | TssD | SMDB11_2263 | 2386232..2386714 | + | 483 | CDG12838.1 | type VI secretion system, effector protein Hcp-like |
SMDB11_2264 | 2386769..2387245 | + | 477 | CDG12839.1 | hypothetical protein | ||
SMDB11_2265 | 2387230..2387604 | + | 375 | CDG12840.1 | hypothetical protein | ||
SMDB11_2266 | 2387650..2388009 | + | 360 | CDG12841.1 | hypothetical protein | ||
SMDB11_2267 | 2388490..2390232 | + | 1743 | CDG12842.1 | type VI secretion system-associated protein,containing FHA domain | ||
SMDB11_2268 | 2390232..2391005 | + | 774 | CDG12843.1 | type VI secretion system, serine/threonine protein phosphatase, PppA-like | ||
SMDB11_2269 | 2391034..2392020 | + | 987 | CDG12844.1 | hypothetical protein | ||
SMDB11_2270 | 2392036..2392857 | + | 822 | CDG12845.1 | type VI secretion system-associated protein,SciE-like | ||
T6CP012956 | TssE | SMDB11_2271 | 2392860..2393435 | + | 576 | CDG12846.1 | type VI secretion system,lysozyme-relatedprotein |
T6CP012957 | TssF | SMDB11_2272 | 2393440..2395326 | + | 1887 | CDG12847.1 | type VI secretion system-associated protein |
T6CP012958 | TssG | SMDB11_2273 | 2395323..2396393 | + | 1071 | CDG12848.1 | type VI secretion system-associated protein |
T6CP012959 | TssH | SMDB11_2274 | 2396450..2399104 | + | 2655 | CDG12849.1 | type VI secretion system ATPase, ClpV1-like |
SMDB11_2275 | 2399154..2400599 | + | 1446 | CDG12850.1 | type VI secretion system, serine/threonine protein kinase | ||
T6CP012960 | TssI | SMDB11_2276 | 2400742..2402670 | + | 1929 | CDG12851.1 | type VI secretion system, effector protein VgrG-like |
SMDB11_2277 | 2402725..2403165 | + | 441 | CDG12852.1 | hypothetical protein | ||
SMDB11_2278 | 2403168..2407589 | + | 4422 | CDG12853.1 | Rhs-family protein |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.






Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|
IMU00316 ![]() |
SMDB11_0928 | EFF01501 ![]() |
Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 972883..973656 (+) | 560172776 |
IMU00318 ![]() |
SMDB11_0929 | EFF01501 ![]() |
Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 973746..974489 (+) | 560172777 |
IMU00319 ![]() |
SMDB11_2278A (RhsI1) | EFF01500 ![]() |
Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 2407591..2408079 (+) | 560174122 |
IMU00320 ![]() |
SMDB11_1611 (RhsI2) | EFF01499 ![]() |
Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 1693944..1694432 (+) | 560173454 |
IMU00354 ![]() |
SMDB11_0809 | EFF01836 ![]() |
Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 838572..838787 (-) | 560172662 |

Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
---|---|---|---|---|---|---|---|---|
ACP00028 ![]() |
SMDB11_4101 (dsbA1) | chaperone | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 4377737..4378360 (-) | 560175924 | SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269 | SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2) |
ACP00029 ![]() |
SMDB11_0239 (dsbA2) | chaperone | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 265001..265642 (+) | 560172104 | SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269 | SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2) |
ACP00030 ![]() |
SMDB11_1609 (eagR2) | adaptor | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 1689187..1689618 (+) | 560173452 | SMDB11_2276 (VgrG2b) | SMDB11_1610 (Rhs2) |
ACP00031 ![]() |
SMDB11_2245 (eagR1) | adaptor | Serratia marcescens subsp. marcescens Db11 | chromosome (HG326223) | 2367474..2367863 (+) | 560174088 | SMDB11_2276 (VgrG2b) | SMDB11_2278 (Rhs1) |