Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS14097  |
| T6SS type | Type i3 |
| Strain | Enterobacter cloacae strain DSM 30054 |
| Replicon (RefSeq) | chromosome (NZ_CP056776) |
| Location | 4037435..4081387 |
| Function | anti-bacterial |
| Comment | Deletion of the tssB1 gene in those predatory strains that were genetically tractable, which abrogated their interbacterial killing capacity. |
| References | [1] Flaugnatti N, Isaac S, Lemos Rocha LF, Stutzmann S, Rendueles O, Stoudmann C, Vesel N, Garcia-Garcera M, Buffet A, Sana TG, Rocha EPC, Blokesch M. et al (2021) Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms.. Nat Commun. 12(1):5751. [PudMed:34599171] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| HWQ16_RS19685 | 4033009..4033800 | + | 792 | WP_044158197.1 | PhnD/SsuA/transferrin family substrate-binding protein | ||
| HWQ16_RS19690 | 4033766..4036054 | - | 2289 | WP_013096172.1 | FdhF/YdeP family oxidoreductase | ||
| HWQ16_RS19695 | 4036917..4037411 | + | 495 | WP_013096174.1 | hypothetical protein | ||
| T6CP210266 | TssJ | HWQ16_RS19700 (tssJ) | 4037435..4037938 | + | 504 | WP_013096175.1 | type VI secretion system lipoprotein TssJ |
| T6CP210267 | TssK | HWQ16_RS19705 (tssK) | 4037964..4039307 | + | 1344 | WP_013096176.1 | type VI secretion system baseplate subunit TssK |
| T6CP210268 | TssL | HWQ16_RS19710 | 4039325..4040563 | + | 1239 | WP_013096177.1 | DotU family type VI secretion system protein |
| T6CP210269 | TssM | HWQ16_RS19715 (tssM) | 4040566..4044186 | + | 3621 | WP_013096178.1 | type VI secretion system membrane subunit TssM |
| HWQ16_RS19720 (tagF) | 4044203..4044919 | + | 717 | WP_013096179.1 | type VI secretion system-associated protein TagF | ||
| T6CP210271 | TssA | HWQ16_RS19725 (tssA) | 4044931..4045947 | + | 1017 | WP_013096180.1 | type VI secretion system protein TssA |
| T6CP210272 | TssB | HWQ16_RS19730 (tssB) | 4046023..4046547 | + | 525 | WP_008502644.1 | type VI secretion system contractile sheath small subunit |
| T6CP210273 | TssC | HWQ16_RS19735 (tssC) | 4046551..4048050 | + | 1500 | WP_013096181.1 | type VI secretion system contractile sheath large subunit |
| T6CP210274 | TssD | HWQ16_RS19740 | 4048386..4048868 | + | 483 | WP_008502640.1 | type VI secretion system tube protein Hcp |
| HWQ16_RS19745 | 4048927..4049418 | + | 492 | WP_013096182.1 | type VI secretion system amidase effector protein Tae4 | ||
| HWQ16_RS19750 | 4049415..4049768 | + | 354 | WP_013096183.1 | hypothetical protein | ||
| HWQ16_RS19755 (tagH) | 4049856..4051625 | + | 1770 | WP_013096184.1 | type VI secretion system-associated FHA domain protein TagH | ||
| HWQ16_RS19760 | 4051622..4052419 | + | 798 | WP_013096185.1 | protein phosphatase 2C domain-containing protein | ||
| HWQ16_RS19765 | 4052436..4053422 | + | 987 | WP_013096186.1 | hypothetical protein | ||
| HWQ16_RS19770 | 4053432..4054244 | + | 813 | WP_013096187.1 | type VI secretion system protein ImpE | ||
| T6CP210278 | TssE | HWQ16_RS19775 (tssE) | 4054237..4054800 | + | 564 | WP_013096188.1 | type VI secretion system baseplate subunit TssE |
| T6CP210279 | TssF | HWQ16_RS19780 (tssF) | 4054803..4056674 | + | 1872 | WP_038420938.1 | type VI secretion system baseplate subunit TssF |
| T6CP210280 | TssG | HWQ16_RS19785 (tssG) | 4056671..4057714 | + | 1044 | WP_013096190.1 | type VI secretion system baseplate subunit TssG |
| T6CP210281 | TssH | HWQ16_RS19790 (tssH) | 4057753..4060368 | + | 2616 | WP_013096191.1 | type VI secretion system ATPase TssH |
| HWQ16_RS19795 | 4060393..4061826 | + | 1434 | WP_013096192.1 | serine/threonine protein kinase | ||
| HWQ16_RS19800 | 4061863..4063281 | + | 1419 | WP_013096193.1 | hypothetical protein | ||
| HWQ16_RS19805 | 4063278..4064039 | + | 762 | WP_013096194.1 | ankyrin repeat domain-containing protein | ||
| HWQ16_RS19810 | 4064356..4064805 | + | 450 | WP_044159334.1 | hypothetical protein | ||
| HWQ16_RS19815 | 4064901..4065869 | + | 969 | WP_013087110.1 | IS5-like element IS903B family transposase | ||
| HWQ16_RS19820 | 4066122..4066595 | + | 474 | pseudogene | hypothetical protein | ||
| HWQ16_RS19825 | 4067018..4067365 | + | 348 | WP_013096196.1 | hypothetical protein | ||
| T6CP210284 | TssI | HWQ16_RS19830 (tssI) | 4067462..4069390 | + | 1929 | WP_013096197.1 | type VI secretion system tip protein VgrG |
| HWQ16_RS19835 | 4069440..4069883 | + | 444 | WP_082208141.1 | ADP-ribosylglycohydrolase family protein | ||
| HWQ16_RS19840 | 4069885..4070853 | + | 969 | WP_013087110.1 | IS5-like element IS903B family transposase | ||
| HWQ16_RS19845 | 4070911..4071606 | + | 696 | pseudogene | ADP-ribosylglycohydrolase family protein | ||
| HWQ16_RS19850 | 4071752..4072185 | + | 434 | pseudogene | hypothetical protein | ||
| T6CP210285 | TssI | HWQ16_RS19855 (tssI) | 4072428..4074350 | + | 1923 | WP_020690884.1 | type VI secretion system tip protein VgrG |
| HWQ16_RS19860 | 4074424..4074843 | + | 420 | WP_052429247.1 | hypothetical protein | ||
| HWQ16_RS19865 | 4074836..4075399 | + | 564 | WP_044158317.1 | hypothetical protein | ||
| HWQ16_RS19870 | 4075403..4076479 | + | 1077 | WP_013096203.1 | hypothetical protein | ||
| HWQ16_RS19875 | 4076555..4076995 | + | 441 | WP_044158315.1 | DUF1795 domain-containing protein | ||
| HWQ16_RS19880 | 4076999..4081387 | + | 4389 | WP_013096205.1 | RHS domain-containing protein | ||
| HWQ16_RS19885 | 4081387..4082385 | + | 999 | WP_013096206.1 | hypothetical protein | ||
| HWQ16_RS19890 | 4083098..4083580 | + | 483 | WP_044158313.1 | hypothetical protein | ||
| HWQ16_RS19895 | 4084076..4084519 | + | 444 | WP_044158311.1 | hypothetical protein | ||
| HWQ16_RS19900 | 4084563..4084673 | - | 111 | pseudogene | DUF933 domain-containing protein | ||
| HWQ16_RS19905 | 4084830..4085261 | + | 432 | WP_013096210.1 | immunity 26/phosphotriesterase HocA family protein | ||
| HWQ16_RS19910 | 4085512..4086045 | + | 534 | pseudogene | RHS repeat-associated core domain-containing protein | ||
| HWQ16_RS19915 | 4086036..4086296 | + | 261 | WP_013096212.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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