Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00396  |
| T6SS type | Type i2 |
| Strain | Enterobacter cloacae subsp. cloacae ATCC 13047 |
| Replicon (RefSeq) | chromosome (NC_014121) |
| Location | 1819466..1844686 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | T6SS-2 is implicated in biofilm formation and adherence to epithelial cells. Both T6SSs are required for intestinal colonization. |
| References | [1] Soria-Bustos J, Ares MA, G��mez-Aldapa CA, Gonz��lez-Y-Merchand JA, Gir��n JA, De la Cruz MA. et al (2020) Two Type VI Secretion Systems of Enterobacter cloacae Are Required for Bacterial Competition, Cell Adherence, and Intestinal Colonization.. Front Microbiol. 11:560488. [PudMed:33072020] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagL | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| ECL_RS08855 (tpx) | 1814799..1815305 | - | 507 | WP_013096423.1 | thiol peroxidase | ||
| ECL_RS08860 (ycjG) | 1815413..1816378 | + | 966 | WP_013096424.1 | L-Ala-D/L-Glu epimerase | ||
| ECL_RS08865 (mpaA) | 1816369..1817082 | - | 714 | WP_013096425.1 | murein tripeptide amidase MpaA | ||
| ECL_RS08870 | 1817265..1818881 | + | 1617 | WP_013096426.1 | peptide ABC transporter substrate-binding protein | ||
| T6CP004069 | TssB | ECL_RS08875 (tssB) | 1819466..1819957 | + | 492 | WP_013096428.1 | type VI secretion system contractile sheath small subunit |
| T6CP004070 | TssC | ECL_RS08880 (tssC) | 1819999..1821540 | + | 1542 | WP_044159362.1 | type VI secretion system contractile sheath large subunit |
| T6CP004071 | TssK | ECL_RS08885 (tssK) | 1821558..1822898 | + | 1341 | WP_013096430.1 | type VI secretion system baseplate subunit TssK |
| T6CP009321 | TssL | ECL_RS08890 (tssL) | 1822895..1823587 | + | 693 | WP_013096431.1 | type VI secretion system protein TssL, short form |
| ECL_RS08895 | 1823584..1825056 | + | 1473 | pseudogene | OmpA family protein | ||
| T6CP004072 | TssH | ECL_RS08900 (tssH) | 1825083..1827341 | + | 2259 | pseudogene | type VI secretion system ATPase TssH |
| ECL_RS08905 (vgrG) | 1827338..1830130 | + | 2793 | pseudogene | type VI secretion system tip protein VgrG | ||
| ECL_RS08910 | 1830127..1830558 | + | 432 | WP_077681880.1 | DUF4431 domain-containing protein | ||
| ECL_RS08915 | 1831369..1832409 | + | 1041 | WP_109455520.1 | TIGR02594 family protein | ||
| ECL_RS08920 | 1832493..1832921 | + | 429 | WP_044159353.1 | hypothetical protein | ||
| ECL_RS08925 | 1833017..1833250 | + | 234 | WP_013096436.1 | hypothetical protein | ||
| ECL_RS08930 | 1833664..1834872 | + | 1209 | WP_013096437.1 | hypothetical protein | ||
| T6CP004073 | TssM | ECL_RS08935 | 1834869..1838342 | + | 3474 | WP_013096438.1 | type VI secretion system protein ImpL |
| T6CP009510 | TssA | ECL_RS08940 (tssA) | 1838342..1839940 | + | 1599 | WP_013096439.1 | type VI secretion system protein TssA |
| ECL_RS08945 | 1839974..1840135 | + | 162 | pseudogene | PAAR domain-containing protein | ||
| ECL_RS08950 | 1840167..1841135 | + | 969 | WP_013087110.1 | IS5-like element IS903B family transposase | ||
| T6CP004074 | TssF | ECL_RS08955 (tssF) | 1841163..1842659 | + | 1497 | pseudogene | type VI secretion system baseplate subunit TssF |
| T6CP004075 | TssG | ECL_RS08960 (tssG) | 1842623..1843708 | + | 1086 | WP_013096442.1 | type VI secretion system baseplate subunit TssG |
| T6CP004076 | TssJ | ECL_RS08965 (tssJ) | 1843686..1844231 | + | 546 | WP_013096443.1 | type VI secretion system lipoprotein TssJ |
| T6CP004077 | TssE | ECL_RS08970 (tssE) | 1844231..1844686 | + | 456 | WP_013096444.1 | type VI secretion system baseplate subunit TssE |
| T6CP009327 | TssA | ECL_RS08975 | 1844710..1846026 | + | 1317 | WP_013096445.1 | type VI secretion system protein VasL |
| ECL_RS08980 | 1846145..1846624 | + | 480 | WP_013096446.1 | hypothetical protein | ||
| ECL_RS08985 | 1846659..1847222 | - | 564 | WP_013096447.1 | DJ-1/PfpI family protein | ||
| ECL_RS08990 | 1847440..1847580 | - | 141 | WP_013096448.1 | Ecr family regulatory small membrane protein | ||
| ECL_RS08995 | 1847655..1848887 | - | 1233 | WP_013096449.1 | sensor domain-containing diguanylate cyclase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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