Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00904  |
| T6SS type | Type i2 |
| Strain | Escherichia coli strain TW-XM |
| Replicon (GenBank) | chromosome (KF678349) |
| Location | 1..29754 |
| Function | anti-eukaryotic; effector translocation |
| Comment | T6SS1-associated mutants presented diminished adherence and invasion of several host cells cultured in vitro, decreased pathogenicity in duck and mouse infection models in vivo, and decreased biofilm formation and bacterial competitive advantage. |
| References | [1] Ma J et al (2014) Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP011013 | TssB | Locus_01 (xmoA) | 1..501 | + | 501 | 611963679 | XmoA |
| T6CP011014 | TssC | Locus_02 (xmoB) | 554..2098 | + | 1545 | 611963680 | XmoB |
| T6CP011015 | TssK | Locus_03 (xmoC) | 2116..3453 | + | 1338 | 611963681 | XmoC |
| T6CP011016 | TssL | Locus_04 (xmoD) | 3450..4115 | + | 666 | 611963682 | XmoD |
| T6CP012399 | TagL | Locus_05 (xmoE) | 4167..5780 | + | 1614 | 611963683 | XmoE |
| T6CP011017 | TssD | Locus_06 (xmoF) | 5838..6329 | + | 492 | 611963684 | Hcp-like protein |
| T6CP011018 | TssH | Locus_07 (xmoG) | 6521..9166 | + | 2646 | 611963685 | putative ATP-dependent Clp protease |
| T6CP011019 | TssI | Locus_08 (xmoH) | 9178..11658 | + | 2481 | 611963686 | XmoH |
| Locus_09 (xmoI) | 11678..13447 | + | 1770 | 611963687 | hypothetical protein | ||
| Locus_10 (xmoJ) | 13422..14132 | + | 711 | 611963688 | hypothetical protein | ||
| Locus_11 (xmoK) | 14223..14516 | + | 294 | 611963689 | hypothetical protein | ||
| T6CP012397 | PAAR | Locus_12 (xmoL) | 14905..15240 | + | 336 | 611963690 | hypothetical protein |
| Locus_13 (xmoM) | 15161..16378 | + | 1218 | 611963691 | hypothetical protein | ||
| T6CP011020 | TssM | Locus_14 (xmoN) | 16388..19741 | + | 3354 | 611963692 | IcmF-like protein |
| T6CP011021 | TssA | Locus_15 (xmoO) | 19707..21344 | + | 1638 | 611963693 | XmoO |
| T6CP012398 | PAAR | Locus_16 (xmoP) | 21344..22927 | + | 1584 | 611963694 | hypothetical protein |
| Locus_17 (xmoQ) | 22927..23556 | + | 630 | 611963695 | hypothetical protein | ||
| Locus_18 (xmoR) | 23813..24256 | + | 444 | 611963696 | hypothetical protein | ||
| T6CP011022 | TssF | Locus_19 (xmoS) | 24626..26386 | + | 1761 | 611963697 | XmoS |
| T6CP011023 | TssG | Locus_20 (xmoT) | 26350..27429 | + | 1080 | 611963698 | XmoT |
| T6CP011024 | TssJ | Locus_21 (xmoU) | 27410..27814 | + | 405 | 611963699 | XmoU |
| T6CP011025 | TssE | Locus_22 (xmoV) | 27950..28378 | + | 429 | 611963700 | XmoV |
| T6CP011026 | TssA | Locus_23 (xmoW) | 28378..29754 | + | 1377 | 611963701 | XmoW |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0270 |
CXG97_03740 (Fur) | protein | Transcription regulator | Escherichia coli strain ExPEC XM | chromosome (NZ_CP025328) | 729474..729920 (-) | 446053847 | T6SS1 (TssB) promotor (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01348 |
xmoI (Tle4) | Tle | IMU00254 |
Escherichia coli strain TW-XM | chromosome (KF678349) | 11678..13447 (+) | 611963687 |
| EFF01309 |
xmoF (Hcp1) | - | - | Escherichia coli strain TW-XM | chromosome (KF678349) | 5838..6329 (+) | 611963684 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00254 |
XmoJ (Tli4) | EFF01348 |
Escherichia coli strain TW-XM | chromosome (KF678349) | 13422..14132 (+) | 611963688 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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