Detailed information of regulator

Summary

Regulator ID	REG0270
Regulator type	protein
Regulatory pathway (from literatures)	Transcription regulator
KEGG pathway (determined by BlastKOALA)	-
Related T6SS	T6SS00904 (Type i2)
Strain	Escherichia coli strain ExPEC XM
Replicon	chromosome
Sequence	Protein sequence (149 a.a.); Nucleotide sequence (447 bp)
Description	Fur directly suppressed the expression of hcp1 clusters through binding directly on the promotor of T6SS1 in the iron replete condition.
Reference	[1] Ma J, Sun M, Pan Z, et al. Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli. Emerg Microbes Infect. 2018 Mar 29;7(1):49. doi: 10.1038/s41426-018-0042-0. PMID: 29593238

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External database links

Locus tag (Gene)	CXG97_03740 (Fur)
Coordinates (Strand)	729474..729920 (-)
NCBI ID	446053847
RefSeq	NZ_CP025328
Uniprot ID	A0A1Z3UTC1_ECOLX, M9FYP0_ECOLX, A0A0E0Y275_ECO1C, S1PU11_ECOLX, L3BQK0_ECOLX, S1EU97_ECOLX, L3QCZ0_ECOLX, S1IH10_ECOLX, L4JEM8_ECOLX, U9XEA5_ECOLX, U9XMU0_ECOLX, V0SEL7_ECOLX, U9Z797_ECOLX, V0UHX9_ECOLX, V0XSD8_ECOLX, V0YEN0_ECOLX, U9ZKF7_ECOLX, A0A0E2L7T8_ECOU3, W0AKV1_9ESCH, A0A080J9N9_ECOLX, A0A029I9Z0_ECOLX, A0A0A0F9M7_ECOLX, FUR_ECOL6, A0A2T3RWP1_9ESCH, D3GXD5_ECO44, Q32IP1_SHIDS, E3PH77_ECOH1, A7ZJ68_ECO24, A0A0E1T3G9_ECOLX, Q1REN4_ECOUT, A0A0H2YX47_ECOK1, B6HYP3_ECOSE, B1LLC7_ECOSM, A0A140NE13_ECOBD, J7RR56_ECOLX, A0A0H3PSJ7_ECO5C, B1EK62_ESCAT, D6I6Q9_ECOLX, D6J7Z7_ECOLX, A0A1X3JTQ8_9ESCH, F4NLS6_ECOLX, A0A2S7SP25_ESCFE, E0J1S2_ECOLW, A0A168XF98_KLEOX, B7UKW4_ECO27, B7MFV0_ECO45, B7LKT0_ESCF3, B7L9M0_ECO55, B7N9S9_ECOLU, A0A0H3MEC8_ECO7I, B7MPI8_ECO81, A0A1Q8NB34_SHIDY, A0A0H7UAJ9_SHISO, A0A1X3JKL5_ECOLX, A0A1X3L6Q9_ECOLX, A0A1X3K9F4_ECOLX, F4VBA2_ECOLX, F4SKN9_ECOLX, A0A1X3I973_ECOLX, A0A0K9TEK7_ECOLX, F4SW14_ECOLX, F4TBP4_ECOLX, A0A1X3LGH2_ECOLX, A0A1X3LUX6_ECOLX, A0A1X3J5F0_ECOLX, E9XNY3_ECOLX, E6BKX3_ECOLX, E1IR72_ECOLX, E1J1I7_ECOLX, D8EDV9_ECOLX, A0A0H3EH26_ECO8N, D3QMM1_ECOCB, A0A0E1LUJ9_ECOLX, D8A8A1_ECOMS, D7XXD9_ECOLX, D7Y974_ECOM1, E9TNB1_ECOLX, I4SMJ0_ECOLX, FUR_ECOLI, FUR_ECO57, I2SYC3_ECOLX, I2UM10_ECOLX, I2WQK1_ECOLX, A0A192CIN2_ECOLX, W8ZEV5_ECOLX, F0JLI7_ESCFE
KEGG ID	ecz:ECS88_0719, eal:EAKF1_ch0779, eci:UTI89_C0687, eco:b0683, ecq:ECED1_0664, elh:ETEC_0700, ebd:ECBD_2978, ecc:c0770, sdy:SDY_0623, eln:NRG857_03085, ecy:ECSE_0745, ect:ECIAI39_0640, elw:ECW_m0735, ecos:EC958_0801, eum:ECUMN_0768, eck:EC55989_0669, efe:EFER_2426, esl:O3K_18225, ecm:EcSMS35_0705, eok:G2583_0844, ecv:APECO1_1381, ecw:EcE24377A_0711, ece:Z0831, ecj:JW0669, elo:EC042_0711, ecg:E2348C_0574, ecs:ECs0714
KEGG pathway (determined by BlastKOALA)	-
PDB ID	2FU4

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  Target

Target	Regulation (↓/↑)	Target sequence
T6SS1 (TssB) promotor	↑	TTGTATATTTTCCTCATCATCATTGCTTTTTATTTAAATCATCCGATAATCCCCTGAATATAATTATGTTAATAACCATCAGAAAAAGTGGATGATGAGGAAAAGGAT Fur box predicted are indicated in red

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Pfam domain hit(s) of regulator

Domain	Pfam ID	E-value	Aligned region
FUR	PF01475.21	1.4e-49	10..130

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Inside	1-148	MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHEGK

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9976	-	-

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  Protein sequence of regulator: 149 a.a.    .Download


  Nucleotide sequence of regulator: 447 bp    .Download