Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01170  |
| T6SS type | Type i1 |
| Strain | Pectobacterium brasiliense 1692 |
| Replicon (RefSeq) | chromosome (NZ_CP047495) |
| Location | 2749401..2774372 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | The T6SS of Pcb1692 inhibits growth of D.chrysanthemi in planta but not in vitro. |
| References | [1] Bellieny-Rabelo D, Tanui CK, Miguel N, Kwenda S, Shyntum DY, Moleleki LN. et al (2019) Transcriptome and Comparative Genomics Analyses Reveal New Functional Insights on Key Determinants of Pathogenesis and Interbacterial Competition in Pectobacterium and Dickeya spp.. Appl Environ Microbiol. 85(2). [PudMed:30413477] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| GT391_RS12265 | 2744417..2746906 | + | 2490 | WP_039320547.1 | S8 family peptidase | ||
| GT391_RS12270 | 2747559..2748191 | - | 633 | WP_010282537.1 | hypothetical protein | ||
| T6CP014884 | TssB | GT391_RS12275 (tssB) | 2749401..2749904 | + | 504 | WP_010282535.1 | type VI secretion system contractile sheath small subunit |
| T6CP014885 | TssC | GT391_RS12280 (tssC) | 2749937..2751415 | + | 1479 | WP_010282534.1 | type VI secretion system contractile sheath large subunit |
| T6CP014886 | TssE | GT391_RS12285 (tssE) | 2751421..2751852 | + | 432 | WP_005972060.1 | type VI secretion system baseplate subunit TssE |
| T6CP014887 | TssF | GT391_RS12290 (tssF) | 2751855..2753621 | + | 1767 | WP_010282521.1 | type VI secretion system baseplate subunit TssF |
| T6CP014888 | TssG | GT391_RS12295 (tssG) | 2753585..2754583 | + | 999 | WP_010282519.1 | type VI secretion system baseplate subunit TssG |
| GT391_RS12300 (tagH) | 2754586..2755806 | + | 1221 | WP_010282517.1 | type VI secretion system-associated FHA domain protein TagH | ||
| T6CP014889 | TssJ | GT391_RS12305 (tssJ) | 2755806..2756327 | + | 522 | WP_010282515.1 | type VI secretion system lipoprotein TssJ |
| T6CP014890 | TssK | GT391_RS12310 (tssK) | 2756330..2757667 | + | 1338 | WP_010282513.1 | type VI secretion system baseplate subunit TssK |
| T6CP014891 | TssL | GT391_RS12315 (icmH) | 2757683..2758459 | + | 777 | WP_010282512.1 | type IVB secretion system protein IcmH/DotU |
| T6CP014892 | TssH | GT391_RS12320 (tssH) | 2758473..2761070 | + | 2598 | WP_039320552.1 | type VI secretion system ATPase TssH |
| GT391_RS12325 | 2761073..2762611 | + | 1539 | WP_010287040.1 | sigma-54 dependent transcriptional regulator | ||
| GT391_RS12330 (tagO) | 2762611..2763171 | + | 561 | WP_010287038.1 | type VI secretion system-associated protein TagO | ||
| T6CP014893 | TssA | GT391_RS12335 (tssA) | 2763183..2764607 | + | 1425 | WP_039320555.1 | type VI secretion system protein TssA |
| T6CP014894 | TssM | GT391_RS12340 (tssM) | 2764632..2768129 | + | 3498 | WP_039320559.1 | type VI secretion system membrane subunit TssM |
| T6CP014895 | TssA | GT391_RS12345 | 2768182..2769618 | + | 1437 | WP_010285391.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| GT391_RS12350 | 2769647..2771002 | + | 1356 | WP_010285388.1 | sel1 repeat family protein | ||
| T6CP014896 | TssD | GT391_RS12355 | 2771621..2772139 | + | 519 | WP_010285381.1 | Hcp family type VI secretion system effector |
| T6CP014897 | TssI | GT391_RS12360 | 2772336..2774372 | + | 2037 | WP_010285378.1 | type VI secretion system tip protein VgrG |
| GT391_RS12365 | 2774382..2775752 | + | 1371 | WP_010285376.1 | PAAR domain-containing protein | ||
| GT391_RS12370 | 2775833..2776531 | + | 699 | WP_010285373.1 | hypothetical protein | ||
| GT391_RS12375 | 2776690..2777646 | + | 957 | WP_010285370.1 | DUF4123 domain-containing protein | ||
| GT391_RS12380 | 2777643..2778560 | + | 918 | WP_010285368.1 | DUF4123 domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0321 |
GT391_RS06470 (expR1) | protein | QS regulatory pathway | Pectobacterium brasiliense strain 1692 | chromosome (NZ_CP047495) | 1453704..1455596 (+) | 746272689 | T6SS transcripts (↓) |
| REG0322 |
GT391_RS06405 (expI) | protein | QS regulatory pathway | Pectobacterium brasiliense strain 1692 | chromosome (NZ_CP047495) | 1436931..1437581 (-) | 497970044 | GT391_RS06470 (expR1) (↓) |
| REG0323 |
GT391_RS16925 (phoP) | protein | TCS-HK | Pectobacterium brasiliense strain 1692 | chromosome (NZ_CP047495) | 3795787..3796476 (-) | 497961604 | GT391_RS06470 (expR1) (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01835 |
GT391_RS21640 (AHH) | Tde | - | Pectobacterium brasiliense strain 1692 | chromosome (NZ_CP047495) | 1694162..1694776 (-) | 1194668254 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|