Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00344  |
| T6SS type | Type i2 |
| Strain | Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 |
| Replicon (RefSeq) | chromosome (NC_012731) |
| Location | 2298791..2328477 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Klebsiella pneumoniae type VI secretion system contributes to bacterial competition, type-1 fimbriae expression, in vivo colonization, and cell invasion. |
| References | [1] Sarris PF et al (2011) Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 11(1):157-66. [PudMed:20932940] [2] Pei-Fang Hsieh, Yi-Rou Lu, Tzu-Lung Lin, Li-Yin Lai, Jin-Town Wang et al (2019) Klebsiella Pneumoniae Type VI Secretion System Contributes to Bacterial Competition, Cell Invasion, Type-1 Fimbriae Expression, and In Vivo Colonization. J Infect Dis. 219(4):637-647. [PudMed:30202982] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Loading, please wait
Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| KP1_RS11195 | 2293921..2294835 | - | 915 | WP_015874717.1 | LysR family transcriptional regulator | ||
| KP1_RS11200 | 2294944..2295705 | + | 762 | WP_040146303.1 | SDR family oxidoreductase | ||
| KP1_RS11205 | 2295922..2297454 | + | 1533 | WP_004224331.1 | HD domain-containing protein | ||
| KP1_RS11210 | 2297653..2298219 | - | 567 | WP_014907729.1 | DJ-1/PfpI family protein | ||
| T6CP003497 | TssB | KP1_RS11220 (tssB) | 2298860..2299351 | + | 492 | WP_004176434.1 | type VI secretion system contractile sheath small subunit |
| T6CP003498 | TssC | KP1_RS11225 (tssC) | 2299394..2300938 | + | 1545 | WP_014907727.1 | type VI secretion system contractile sheath large subunit |
| T6CP003499 | TssK | KP1_RS11230 (tssK) | 2300948..2302291 | + | 1344 | WP_004224345.1 | type VI secretion system baseplate subunit TssK |
| T6CP009312 | TssL | KP1_RS11235 | 2302288..2302977 | + | 690 | WP_004176431.1 | type VI secretion system protein TssL, short form |
| T6CP011754 | TagL | KP1_RS11240 | 2302974..2304680 | + | 1707 | WP_014907726.1 | OmpA family protein |
| T6CP009456 | TssD | KP1_RS11245 (hcp) | 2304685..2305176 | + | 492 | WP_002902160.1 | type VI secretion system effector Hcp |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Loading, please wait
Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0203 | KP1_3314 (hns) | protein | Global regulator | Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 | chromosome (NC_012731) | 3140175..3140582 (+) | 238895262 | KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑) |
Showing 1 to 1 of 1 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
Loading, please wait
Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
Loading, please wait
Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||