Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00344  |
| T6SS type | Type i2 |
| Strain | Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 |
| Replicon (RefSeq) | chromosome (NC_012731) |
| Location | 2298791..2328477 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Klebsiella pneumoniae type VI secretion system contributes to bacterial competition, type-1 fimbriae expression, in vivo colonization, and cell invasion. |
| References | [1] Sarris PF et al (2011) Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 11(1):157-66. [PudMed:20932940] [2] Pei-Fang Hsieh, Yi-Rou Lu, Tzu-Lung Lin, Li-Yin Lai, Jin-Town Wang et al (2019) Klebsiella Pneumoniae Type VI Secretion System Contributes to Bacterial Competition, Cell Invasion, Type-1 Fimbriae Expression, and In Vivo Colonization. J Infect Dis. 219(4):637-647. [PudMed:30202982] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| KP1_RS11195 | 2293921..2294835 | - | 915 | WP_015874717.1 | LysR family transcriptional regulator | ||
| KP1_RS11200 | 2294944..2295705 | + | 762 | WP_040146303.1 | SDR family oxidoreductase | ||
| KP1_RS11205 | 2295922..2297454 | + | 1533 | WP_004224331.1 | HD domain-containing protein | ||
| KP1_RS11210 | 2297653..2298219 | - | 567 | WP_014907729.1 | DJ-1/PfpI family protein | ||
| T6CP003497 | TssB | KP1_RS11220 (tssB) | 2298860..2299351 | + | 492 | WP_004176434.1 | type VI secretion system contractile sheath small subunit |
| T6CP003498 | TssC | KP1_RS11225 (tssC) | 2299394..2300938 | + | 1545 | WP_014907727.1 | type VI secretion system contractile sheath large subunit |
| T6CP003499 | TssK | KP1_RS11230 (tssK) | 2300948..2302291 | + | 1344 | WP_004224345.1 | type VI secretion system baseplate subunit TssK |
| T6CP009312 | TssL | KP1_RS11235 | 2302288..2302977 | + | 690 | WP_004176431.1 | type VI secretion system protein TssL, short form |
| T6CP011754 | TagL | KP1_RS11240 | 2302974..2304680 | + | 1707 | WP_014907726.1 | OmpA family protein |
| T6CP009456 | TssD | KP1_RS11245 (hcp) | 2304685..2305176 | + | 492 | WP_002902160.1 | type VI secretion system effector Hcp |
| T6CP003500 | TssH | KP1_RS11250 (tssH) | 2305440..2308094 | + | 2655 | WP_015874721.1 | type VI secretion system ATPase TssH |
| T6CP003501 | TssI | KP1_RS11255 (vgrG) | 2308087..2310786 | + | 2700 | WP_041168969.1 | type VI secretion system tip protein VgrG |
| KP1_RS11260 | 2310789..2311199 | + | 411 | WP_064175886.1 | DUF4431 domain-containing protein | ||
| KP1_RS11265 | 2311217..2313139 | + | 1923 | WP_015874724.1 | LysM peptidoglycan-binding domain-containing protein | ||
| KP1_RS27675 | 2313136..2313658 | + | 523 | pseudogene | hypothetical protein | ||
| KP1_RS30230 | 2313827..2313931 | + | 105 | WP_015874726.1 | transposase | ||
| KP1_RS30235 | 2313903..2314094 | + | 192 | WP_015874727.1 | transposase | ||
| KP1_RS28790 | 2314145..2314939 | + | 795 | WP_086074293.1 | IS3 family transposase | ||
| KP1_RS27685 | 2314926..2315996 | + | 1071 | WP_014907718.1 | TIGR02594 family protein | ||
| KP1_RS27690 | 2316173..2316518 | + | 346 | pseudogene | maltose transporter permease | ||
| KP1_RS11290 | 2317266..2318474 | + | 1209 | WP_032430730.1 | hypothetical protein | ||
| T6CP003502 | TssM | KP1_RS11295 | 2318471..2321926 | + | 3456 | WP_049127998.1 | type VI secretion protein VasK |
| T6CP009457 | TssA | KP1_RS11300 (tssA) | 2321926..2323524 | + | 1599 | WP_015874732.1 | type VI secretion system protein TssA |
| T6CP011753 | PAAR | KP1_RS11305 | 2323555..2324610 | + | 1056 | WP_014907714.1 | PAAR domain-containing protein |
| KP1_RS11310 | 2324607..2325077 | + | 471 | WP_015874733.1 | hypothetical protein | ||
| T6CP003503 | TssF | KP1_RS11315 (tssF) | 2325154..2326908 | + | 1755 | WP_004190505.1 | type VI secretion system baseplate subunit TssF |
| T6CP003504 | TssG | KP1_RS11320 (tssG) | 2326872..2327957 | + | 1086 | WP_004190503.1 | type VI secretion system baseplate subunit TssG |
| T6CP003505 | TssJ | KP1_RS11325 (tssJ) | 2327935..2328477 | + | 543 | WP_004176417.1 | type VI secretion system lipoprotein TssJ |
| KP1_RS11330 | 2328604..2329098 | + | 495 | WP_014907712.1 | hypothetical protein | ||
| KP1_RS11335 (bdcA) | 2329165..2329878 | - | 714 | WP_014907711.1 | SDR family oxidoreductase | ||
| KP1_RS11340 | 2329952..2330545 | + | 594 | WP_014907710.1 | TetR/AcrR family transcriptional regulator | ||
| KP1_RS11345 | 2330550..2331305 | - | 756 | WP_004151596.1 | SDR family oxidoreductase | ||
| KP1_RS11350 | 2331464..2332342 | + | 879 | WP_015874735.1 | AraC family transcriptional regulator | ||
| KP1_RS11355 | 2332393..2332599 | - | 207 | WP_004212334.1 | DUF1471 domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0203 |
KP1_3314 (hns) | protein | Global regulator | Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 | chromosome (NC_012731) | 3140175..3140582 (+) | 238895262 | KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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