SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP009312
Component protein type	TssL
T6SS ID (Type)	T6SS00344 (Type i2)
Strain	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Replicon	chromosome
Sequence	Protein sequence (230 a.a.); Nucleotide sequence (690 bp)
Reference	[1] Sarris PF, Zoumadakis C, Panopoulos NJ, et al. Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 2011 Jan;11(1):157-66. doi: 10.1016/j.meegid.2010.09.006. Epub 2010 Oct 4. PMID: 20932940 [2] Hsieh PF, Lu YR, Lin TL, et al. Klebsiella pneumoniae Type VI Secretion System Contributes to Bacterial Competition, Cell Invasion, Type-1 Fimbriae Expression, and In Vivo Colonization. J Infect Dis. 2019 Jan 29;219(4):637-647. doi: 10.1093/infdis/jiy534. PMID: 30202982

Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene)	KP1_RS11235
Coordinate (Strand)	2302288..2302977 (+)
NCBI ID	WP_004176431.1
RefSeq	NC_012731
Uniprot ID	A0A7U7IGM2_KLEPN, V0B0K3_KLEPN, A0A7H4SFI2_KLEVA, A0A652Q1E0_9ENTR, A6T836_KLEP7, A0A3S4MD95_KLEAE, W9BP37_KLEPN, A0A377ZU02_KLEPN
KEGG ID	kpnk:BN49_2465, kpk:A593_21460, kpn:KPN_01325, kpv:KPNIH29_11390, kpy:KPNIH31_11040, kpt:VK055_1103
PDB ID	-

Pfam domain hit(s)

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Domain	Pfam ID	E-value	Aligned region
DotU	PF09850.11	3.3e-30	14..215

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Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction	Region	Sequence
Outside	1-229	VNEPKRGNAASIDIDALLQNTWLQVISLRHGPQFRDEEGYTLWQRCIADVERVQHELKASGLDDASCQHILTAQCALLDEAVKGRGVEDEACLQWYDIPLQGHFLGTMDAGDTLCERMRDVLREPAPNLAVVTCFQRVMLLGFIGSFRSLHDPERLKLVNALGERVPPFQCPATAPVLVESRAGLGISGWLAPWPVRIGLSVVVVLALWWGLNHWLDHLLLTLLPGEVK

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

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Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9974	-	-

Protein sequence: 230 a.a.

						>T6CP009312 NC_012731:2302288-2302977 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] [TssL]
VNEPKRGNAASIDIDALLQNTWLQVISLRHGPQFRDEEGYTLWQRCIADVERVQHELKASGLDDASCQHILTAQCALLDE
AVKGRGVEDEACLQWYDIPLQGHFLGTMDAGDTLCERMRDVLREPAPNLAVVTCFQRVMLLGFIGSFRSLHDPERLKLVN
ALGERVPPFQCPATAPVLVESRAGLGISGWLAPWPVRIGLSVVVVLALWWGLNHWLDHLLLTLLPGEVK*					

Nucleotide sequence: 690 bp

						>T6CP009312 NC_012731:2302288-2302977 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] [TssL]
GTGAATGAGCCTAAACGCGGCAACGCCGCGTCCATTGATATTGATGCGCTGCTGCAGAACACCTGGCTGCAGGTTATCAG
CCTGCGCCACGGCCCGCAGTTCCGCGATGAGGAAGGGTACACGCTATGGCAGCGCTGTATTGCTGATGTCGAGCGCGTGC
AACATGAGCTGAAGGCGAGCGGGCTTGATGACGCCAGCTGTCAGCATATTCTCACCGCCCAGTGCGCGCTGCTCGATGAA
GCAGTGAAAGGTCGCGGCGTGGAGGATGAGGCCTGCCTGCAGTGGTATGACATTCCGCTGCAGGGGCACTTCCTCGGCAC
CATGGACGCCGGCGACACCCTGTGCGAGCGGATGCGTGATGTGTTGCGTGAACCGGCGCCCAACCTGGCCGTGGTCACCT
GTTTTCAGCGGGTGATGCTGCTGGGTTTTATTGGCAGCTTTCGCTCCCTCCACGACCCCGAGCGCCTGAAGCTGGTCAAC
GCGCTCGGTGAGCGTGTTCCTCCTTTTCAGTGCCCGGCTACCGCTCCCGTACTGGTAGAGAGTCGCGCCGGTCTGGGGAT
AAGCGGCTGGCTGGCCCCATGGCCGGTACGTATTGGCCTGAGCGTGGTGGTGGTACTCGCCCTGTGGTGGGGGCTCAACC
ACTGGCTCGATCACCTGCTGCTGACCTTGTTACCGGGGGAGGTGAAATGA					