Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


T6SS ID T6SS17501 experimental
T6SS type Type i3
Strain Neisseria cinerea isolate CCUG346T (346T)
Replicon (GenBank) chromosome (346T_plasmid)
Location 26951..47415
Function anti-bacterial
Comment Competition assays between N. cinerea 346T or the ΔT6SS mutant against N. cinerea 27178A which lacks a T6SS and Nte/Nti pairs identified in N. cinerea 346T were performed. The survival of N. cinerea 27178A was reduced by around an order of magnitude following incubation with N. cinerea 346T compared with the ΔT6SS mutant, confirming that the N. cinerea 346T T6SS is active during inter-bacterial competition.
[1] Custodio R, Ford RM, Ellison CJ, Liu G, Mickute G, Tang CM, Exley RM. et al (2021) Type VI secretion system killing by commensal Neisseria is influenced by expression of type four pili.. Elife. 10. [PudMed:34232858]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
Locus_08 26395..26946 + 552 pseudogene ype VI secretion-associated protein, BMA_A0400 family; Members of this protein family are found exclusively, although not universally, in bacterial species that possess a type VI secretion system. Genes are found in type VI secretion-associated gene clusters. The specific function is unknown. This model represents the rather well-conserved amino-terminal domain of a protein family in which carboxy-terminal regions, when present, show little conservation. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]
T6CP259504 TssA Locus_09 26951..28018 + 1068 pseudogene -
T6CP259505 TssB Locus_10 28086..28604 + 519 pseudogene or Hcp2
T6CP259506 TssC Locus_11 28638..30137 + 1500 pseudogene -
Locus_12 36746..36757 + 12 pseudogene Factor Xa recognition and cleavage site
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector