Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00947 experimental
T6SS type Type Unknown
Strain Escherichia coli strain PE050 VgrG island
Replicon (GenBank) chromosome I (KX118292)
Location 1..4946
Function anti-bacterial
Comment ETEC strains lacking vt1 or vgrG displayed a marked impairment in their capacity to kill Δvt1Δvti1 recipient cells, and vgrG and icmF are required for the antibacterial capacity of vt1+ strains.
References
[1] Jiale Ma, Min Sun, Zihao Pan, Chengping Lu, Huochun Yao et al (2018) Diverse Toxic Effectors Are Harbored by vgrG Islands for Interbacterial Antagonism in Type VI Secretion System. Biochim Biophys Acta Gen Subj. 1862(7):1635-1643. [PudMed:29674124]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentVt6AVt6BVt6CVt6D
Number1111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
T6CP016163 Vt6A Locus_01 (vt6A) 1..2481 + 2481 1062685202 Vgr family protein
T6CP016164 Vt6B Locus_02 (vt6B) 2514..3167 + 654 1062685203 VT6 amidase_2 toxin protein
T6CP016165 Vt6C Locus_03 (vt6C) 3177..3626 + 450 1062685204 VT6 immunity protein
T6CP016166 Vt6D Locus_04 (vt6D) 3732..4946 + 1215 1062685205 hypothetical protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF01527 experimental vt6B (VT1) Tae IMU00328 experimental Escherichia coli strain PE050 chromosome (KX118292) 2514..3167 (+) 1062685203
EFF01531 experimental vt6C (VTI1) Tse - Escherichia coli strain PE050 chromosome (KX118292) 3177..3626 (+) 1062685204

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
IMU00328 experimental vt6C (VTI1) EFF01527 experimental Escherichia coli strain PE050 chromosome (KX118292) 3177..3626 (+) 1062685203

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector