SecReT6, T6SS database

Detailed information of effector

Summary

Effector ID	EFF01479
Effector type	-
Cognate immunity protein	-
Related T6SS (Type)	T6SS00905 (Type i1)
Strain	Escherichia coli strain TW-XM
Replicon	chromosome
Sequence	Protein sequence (160 a.a.); Nucleotide sequence (480 bp)
Description	Hcp2A
Reference	[1] Ma J, Sun M, Pan Z, et al. Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli. Emerg Microbes Infect. 2018 Mar 29;7(1):49. doi: 10.1038/s41426-018-0042-0. PMID: 29593238

Experimental investigation has been performed.

Bioinformatics investigation has been performed

External database links

Locus tag (Gene)	xmtA (Hcp2A)
Coordinates (Strand)	1..480 (-)
NCBI ID	611963703
GenBank	KF678350
Uniprot ID	Q6TKT6_ECOLX
KEGG ID	-
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
T6SS_HCP	PF05638.14	4.2e-22	7..143

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-159	MANPVYLTLNGELQGLISSGCSSMPSIGNKAQIAHQDQIMVTSLSHGLSRAQNVNHQELTITKPVDKSSPLLGKAISENECLTCDFVFYRTNRFGINEPYYKLKLANARLSNIGLTVPHTINDSPGQAEESVSFTYESINWEHSVAGTSAYSLWSERIF

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.5814	-	-

Protein sequence: 160 a.a. .

                                    >EFF01479 KF678350:c480-1  (Unknown) [Escherichia coli]
MANPVYLTLNGELQGLISSGCSSMPSIGNKAQIAHQDQIMVTSLSHGLSRAQNVNHQELTITKPVDKSSPLLGKAISENE
CLTCDFVFYRTNRFGINEPYYKLKLANARLSNIGLTVPHTINDSPGQAEESVSFTYESINWEHSVAGTSAYSLWSERIF*

                                

Nucleotide sequence: 480 bp .

                                    >EFF01479 KF678350:c480-1  (Unknown) [Escherichia coli]
ATGGCAAATCCCGTCTATCTGACACTGAACGGAGAACTTCAGGGGCTGATTTCATCCGGATGCTCGTCAATGCCGTCCAT
CGGTAACAAAGCCCAGATTGCACATCAGGATCAGATCATGGTGACGTCACTGTCCCATGGTCTGAGCCGTGCGCAGAATG
TCAACCATCAGGAGTTGACCATCACGAAACCGGTGGACAAATCCTCCCCTCTGCTGGGCAAGGCCATTTCAGAGAATGAA
TGTCTGACCTGTGATTTTGTATTCTACCGCACCAACCGCTTTGGAATTAATGAACCGTACTACAAGCTGAAACTGGCTAA
CGCCCGGCTCTCAAACATCGGCCTTACCGTTCCCCATACCATTAACGACAGTCCAGGGCAGGCGGAAGAGTCTGTGTCAT
TTACCTATGAGAGCATCAATTGGGAGCACAGCGTCGCCGGAACCAGTGCATACAGCCTTTGGAGTGAACGGATTTTCTAA

                                