Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00905  |
| T6SS type | Type i1 |
| Strain | Escherichia coli strain TW-XM |
| Replicon (GenBank) | chromosome (KF678350) |
| Location | 1..25901 |
| Function | anti-eukaryotic; effector translocation |
| Comment | T6SS2-associated mutants only presented a significant decrease in the adherence and invasion of mice brain microvascular endothelial cells (BMEC) bEnd.3 and brain tissue of duck infection model. |
| References | [1] Ma J et al (2014) Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP011027 | TssD | Locus_01 (xmtA) | 1..480 | - | 480 | 611963703 | Hcp-like protein |
| T6CP011028 | TssA | Locus_02 (xmtB) | 498..1940 | - | 1443 | 611963704 | XmtB |
| T6CP011029 | TssM | Locus_03 (xmtC) | 1867..5334 | - | 3468 | 611963705 | IcmF-like protein |
| T6CP011030 | TssA | Locus_04 (xmtD) | 5414..6856 | - | 1443 | 611963706 | XmtD |
| Locus_05 (xmtE) | 6932..7570 | - | 639 | 611963707 | XmtE | ||
| T6CP011031 | TssH | Locus_06 (xmtF) | 7618..10377 | - | 2760 | 611963708 | putative ATP-dependent Clp protease |
| T6CP011032 | TssL | Locus_07 (xmtG) | 10387..11151 | - | 765 | 611963709 | XmtG |
| T6CP011033 | TssK | Locus_08 (xmtH) | 11156..12502 | - | 1347 | 611963710 | XmtH |
| T6CP011034 | TssJ | Locus_09 (xmtI) | 12505..13029 | - | 525 | 611963711 | XmtI |
| T6CP012400 | FHA | Locus_10 (xmtJ) | 13026..14306 | - | 1281 | 611963712 | XmtJ |
| T6CP011035 | TssG | Locus_11 (xmtK) | 14323..15372 | - | 1050 | 611963713 | XmtK |
| T6CP011036 | TssF | Locus_12 (xmtL) | 15336..17042 | - | 1707 | 611963714 | XmtL |
| T6CP011037 | TssE | Locus_13 (xmtM) | 17183..17608 | - | 426 | 611963715 | XmtM |
| T6CP011038 | TssC | Locus_14 (xmtN) | 17613..18140 | - | 528 | 611963716 | XmtN |
| T6CP011039 | TssC | Locus_15 (xmtO) | 18334..19098 | - | 765 | 611963717 | XmtO |
| T6CP011040 | TssB | Locus_16 (xmtP) | 19121..19624 | - | 504 | 611963718 | XmtP |
| Locus_17 (xmtQ) | 20095..20253 | - | 159 | 611963719 | hypothetical protein | ||
| T6CP011041 | TssD | Locus_18 (xmtR) | 20330..20848 | + | 519 | 611963720 | Hcp-like protein |
| T6CP011042 | TssI | Locus_19 (xmtS) | 21069..23051 | + | 1983 | 611963721 | XmtS |
| Locus_20 (xmtT) | 23158..24204 | + | 1047 | 611963722 | hypothetical protein | ||
| T6CP012401 | PAAR | Locus_21 (xmtU) | 24197..25636 | + | 1440 | 611963723 | hypothetical protein |
| Locus_22 (xmtV) | 25611..25901 | + | 291 | 611963724 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01479 |
xmtA (Hcp2A) | - | - | Escherichia coli strain TW-XM | chromosome (KF678350) | 1..480 (-) | 611963703 |
| EFF01480 |
xmtR (Hcp2B) | - | - | Escherichia coli strain TW-XM | chromosome (KF678350) | 20330..20848 (+) | 611963720 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00327 |
XmtV | EFF01498 |
Escherichia coli strain TW-XM | chromosome (KF678350) | 25611..25901 (+) | 611963724 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|