Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01290  |
| T6SS type | Type i1 |
| Strain | Vibrio cholerae DL4215 |
| Replicon (RefSeq) | chromosome (NZ_MOLM01000011) |
| Location | 74535..98377 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Smooth isolates DL4211 and DL4215 produced Hcp at sufficient levels to be detected by western blots probed with Hcp antiserum and killed D. discoideum at levels comparable to V52, as well as engaging in T6SS-mediated virulence and intrabacterial competition. |
| References | [1] Unterweger D et al (2012) Constitutive type VI secretion system expression gives Vibrio cholerae intra- and interspecific competitive advantages. PLoS One. 7(10):e48320. [PudMed:23110230] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagH | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BL246_RS05905 | 70380..72059 | - | 1680 | 487887011 | RluA family pseudouridine synthase | ||
| BL246_RS05910 | 72831..73115 | + | 285 | 446448551 | type VI secretion system PAAR protein | ||
| BL246_RS05915 | 73183..74103 | + | 921 | 447109437 | sel1 repeat family protein | ||
| T6CP016002 | TssB | BL246_RS05920 (tssB) | 74535..75041 | + | 507 | 445953536 | type VI secretion system contractile sheath small subunit |
| T6CP016003 | TssC | BL246_RS05925 (tssC) | 75085..76560 | + | 1476 | 446030285 | type VI secretion system contractile sheath large subunit |
| T6CP016004 | TssE | BL246_RS05930 (tssE) | 76563..77000 | + | 438 | 446143145 | type VI secretion system baseplate subunit TssE |
| T6CP016005 | TssF | BL246_RS05935 (tssF) | 77006..78775 | + | 1770 | 446111937 | type VI secretion system baseplate subunit TssF |
| T6CP016006 | TssG | BL246_RS05940 (tssG) | 78739..79755 | + | 1017 | 487887020 | type VI secretion system baseplate subunit TssG |
| T6CP016007 | TagH | BL246_RS05945 (tagH) | 79758..81242 | + | 1485 | 1133529381 | type VI secretion system-associated FHA domain protein TagH |
| T6CP016008 | TssJ | BL246_RS05950 (tssJ) | 81245..81721 | + | 477 | 446968055 | type VI secretion system lipoprotein TssJ |
| T6CP016009 | TssK | BL246_RS05955 (tssK) | 81728..83062 | + | 1335 | 446380152 | type VI secretion system baseplate subunit TssK |
| T6CP016010 | TssL | BL246_RS05960 | 83065..83838 | + | 774 | 446005552 | type IVB secretion system protein IcmH/DotU |
| T6CP016011 | TssH | BL246_RS05965 (tssH) | 83864..86473 | + | 2610 | 446541785 | type VI secretion system ATPase TssH |
| BL246_RS05970 (vasH) | 86476..88068 | + | 1593 | 1133529382 | sigma-54 dependent T6SS transcriptional regulator VasH | ||
| BL246_RS05975 (tagO) | 88065..88721 | + | 657 | 694139269 | type VI secretion system-associated protein TagO | ||
| T6CP016012 | TssA | BL246_RS05980 (vasJ) | 88731..90137 | + | 1407 | 1133529384 | TssA family type VI secretion system protein VasJ |
| T6CP016013 | TssM | BL246_RS05985 (tssM) | 90198..93698 | + | 3501 | 446147150 | type VI secretion system membrane subunit TssM |
| T6CP016014 | TssA | BL246_RS05990 | 93749..95011 | + | 1263 | 1860428251 | ImpA family type VI secretion system protein |
| T6CP016015 | TssI | BL246_RS06000 (tssI) | 95264..98377 | + | 3114 | 1133529386 | type VI secretion system tip protein VgrG |
| BL246_RS06005 | 98364..98747 | + | 384 | 1133529387 | hypothetical protein | ||
| BL246_RS06010 | 99125..99385 | - | 261 | 446721926 | DUF3012 domain-containing protein | ||
| BL246_RS06015 (rbsD) | 99669..100088 | + | 420 | 446672572 | D-ribose pyranase | ||
| BL246_RS06020 (rbsA) | 100115..101617 | + | 1503 | 1133529388 | ribose ABC transporter ATP-binding protein RbsA | ||
| BL246_RS06025 (rbsC) | 101647..102615 | + | 969 | 487817684 | ribose ABC transporter permease |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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