Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00068  |
| T6SS type | Type i3 |
| Strain | Burkholderia mallei ATCC 23344 |
| Replicon (RefSeq) | chromosome II (NC_006349) |
| Location | 376517..411529 |
| Function | - |
| Comment | - |
| References | [1] Schell MA et al (2007) Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BMA_RS17920 | 371884..372825 | - | 942 | WP_004190962.1 | LysR family transcriptional regulator | ||
| BMA_RS17925 | 372922..374237 | + | 1316 | pseudogene | D-serine ammonia-lyase | ||
| BMA_RS17930 | 374408..375322 | - | 915 | WP_004190523.1 | LysR family transcriptional regulator | ||
| BMA_RS17935 | 375504..376208 | + | 705 | WP_004190791.1 | SDR family oxidoreductase | ||
| BMA_RS26115 | 376770..376946 | - | 177 | WP_004190854.1 | hypothetical protein | ||
| BMA_RS17940 | 376995..377312 | - | 318 | WP_004205458.1 | chorismate lyase | ||
| BMA_RS17945 | 377249..377494 | - | 246 | WP_073699052.1 | chorismate lyase | ||
| BMA_RS17950 | 377622..378857 | - | 1236 | WP_038796415.1 | flavin-dependent oxidoreductase | ||
| BMA_RS17955 | 379131..379316 | - | 186 | WP_004190842.1 | hypothetical protein | ||
| BMA_RS17960 | 379335..381233 | + | 1899 | WP_004203280.1 | DUF3857 and transglutaminase domain-containing protein | ||
| T6CP011466 | FHA | BMA_RS17965 (tagH) | 381276..382712 | - | 1437 | WP_004190504.1 | type VI secretion system-associated FHA domain protein TagH |
| BMA_RS17970 | 382767..383168 | - | 402 | WP_004190377.1 | TssQ family T6SS-associated lipoprotein | ||
| T6CP000583 | TssJ | BMA_RS17975 (tssJ) | 383808..384326 | + | 519 | WP_004190712.1 | type VI secretion system lipoprotein TssJ |
| T6CP000584 | TssK | BMA_RS17980 (tssK) | 384323..385726 | + | 1404 | WP_004190585.1 | type VI secretion system baseplate subunit TssK |
| T6CP000585 | TssL | BMA_RS17985 | 385742..387058 | + | 1317 | WP_004190689.1 | DotU family type VI secretion system protein |
| T6CP000586 | TssM | BMA_RS17990 (tssM) | 387061..390690 | + | 3630 | WP_004190681.1 | type VI secretion system membrane subunit TssM |
| BMA_RS17995 (tagF) | 390687..391602 | + | 916 | pseudogene | type VI secretion system-associated protein TagF | ||
| BMA_RS18000 | 391587..391814 | - | 228 | WP_004190273.1 | hypothetical protein | ||
| BMA_RS18005 | 391813..394410 | + | 2598 | WP_004190797.1 | protein kinase | ||
| T6CP000587 | TssA | BMA_RS18010 (tssA) | 394463..395542 | + | 1080 | WP_004190988.1 | type VI secretion system protein TssA |
| T6CP000588 | TssB | BMA_RS18015 (tssB) | 395605..396183 | + | 579 | WP_004190671.1 | type VI secretion system contractile sheath small subunit |
| T6CP000589 | TssC | BMA_RS18020 (tssC) | 396176..397684 | + | 1509 | WP_004190849.1 | type VI secretion system contractile sheath large subunit |
| T6CP000590 | TssD | BMA_RS18025 | 397744..398235 | + | 492 | WP_004190698.1 | type VI secretion system tube protein Hcp |
| T6CP000591 | TssE | BMA_RS18030 (tssE) | 398254..398814 | + | 561 | WP_004196148.1 | type VI secretion system baseplate subunit TssE |
| T6CP000592 | TssF | BMA_RS18035 (tssF) | 398819..400690 | + | 1872 | WP_004190509.1 | type VI secretion system baseplate subunit TssF |
| T6CP000593 | TssG | BMA_RS18040 (tssG) | 400687..402177 | + | 1491 | WP_004196149.1 | type VI secretion system baseplate subunit TssG |
| T6CP000594 | TssH | BMA_RS18045 (tssH) | 402156..404810 | + | 2655 | WP_004190714.1 | type VI secretion system ATPase TssH |
| T6CP000595 | TssI | BMA_RS18050 (tssI) | 404807..407011 | + | 2205 | WP_004203275.1 | type VI secretion system tip protein VgrG |
| BMA_RS18055 | 407086..407739 | + | 654 | WP_004196151.1 | hypothetical protein | ||
| BMA_RS18060 | 407669..408727 | + | 1059 | WP_004196154.1 | RHS repeat protein | ||
| BMA_RS18065 | 408755..409875 | - | 1121 | WP_038802950.1 | IS3 family transposase | ||
| BMA_RS18070 | 409943..410536 | - | 594 | pseudogene | acyltransferase family protein | ||
| BMA_RS18075 | 410549..411529 | - | 981 | WP_011204340.1 | class I SAM-dependent methyltransferase | ||
| BMA_RS18080 | 412046..413470 | + | 1425 | WP_004190776.1 | cytosine permease | ||
| BMA_RS18085 | 413467..414405 | + | 939 | WP_004190245.1 | NAD-dependent protein deacetylase | ||
| BMA_RS18090 | 414368..415045 | + | 678 | WP_004190461.1 | DUF938 domain-containing protein | ||
| BMA_RS18095 | 415369..415512 | - | 144 | WP_004190588.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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