Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00256  |
| T6SS type | Type i1 |
| Strain | Yersinia pseudotuberculosis YPIII |
| Replicon (RefSeq) | chromosome (NC_010465) |
| Location | 418592..452916 |
| Function | - |
| Comment | - |
| References | [1] Zhang W et al (2011) Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257] [2] Zhang W et al (2012) A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| YPK_RS01905 | 413857..414084 | + | 228 | WP_042593159.1 | hypothetical protein | ||
| YPK_RS01910 (malK) | 414088..415197 | + | 1110 | WP_002212091.1 | maltose/maltodextrin ABC transporter ATP-binding protein MalK | ||
| YPK_RS01915 | 415268..416539 | + | 1272 | WP_002212092.1 | maltoporin | ||
| YPK_RS01920 (malM) | 416780..417691 | + | 912 | WP_002212093.1 | maltose operon protein MalM | ||
| YPK_RS01925 | 418162..418440 | + | 279 | WP_041176035.1 | hypothetical protein | ||
| T6CP008675 | TssD | YPK_RS01930 | 418592..419110 | - | 519 | WP_002212097.1 | Hcp family type VI secretion system effector |
| T6CP002528 | TssB | YPK_RS01935 (tssB) | 419634..420131 | + | 498 | WP_002212098.1 | type VI secretion system contractile sheath small subunit |
| T6CP002529 | TssC | YPK_RS01940 (tssC) | 420199..421680 | + | 1482 | WP_002230616.1 | type VI secretion system contractile sheath large subunit |
| T6CP008676 | TssE | YPK_RS01945 (tssE) | 421687..422127 | + | 441 | WP_002212100.1 | type VI secretion system baseplate subunit TssE |
| T6CP002530 | TssF | YPK_RS01950 (tssF) | 422127..423947 | + | 1821 | WP_011193201.1 | type VI secretion system baseplate subunit TssF |
| T6CP002531 | TssG | YPK_RS01955 (tssG) | 423911..424981 | + | 1071 | WP_012303451.1 | type VI secretion system baseplate subunit TssG |
| T6CP011646 | FHA | YPK_RS01960 (tagH) | 425107..426423 | + | 1317 | WP_012303452.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP002532 | TssJ | YPK_RS01965 (tssJ) | 426423..426968 | + | 546 | WP_012104358.1 | type VI secretion system lipoprotein TssJ |
| T6CP002533 | TssK | YPK_RS01970 (tssK) | 426971..428317 | + | 1347 | WP_002212105.1 | type VI secretion system baseplate subunit TssK |
| T6CP002534 | TssL | YPK_RS01975 | 428317..429084 | + | 768 | WP_002212106.1 | type IVB secretion system protein IcmH/DotU |
| T6CP002535 | TssH | YPK_RS01980 (tssH) | 429095..431698 | + | 2604 | WP_012303453.1 | type VI secretion system ATPase TssH |
| YPK_RS01985 | 431695..432492 | + | 798 | WP_002212108.1 | Fis family transcriptional regulator | ||
| YPK_RS01990 (tagO) | 432489..433175 | + | 687 | WP_012303454.1 | type VI secretion system-associated protein TagO | ||
| T6CP008677 | TssA | YPK_RS01995 (tssA) | 433181..434569 | + | 1389 | WP_012303455.1 | type VI secretion system protein TssA |
| T6CP002536 | TssM | YPK_RS02000 (tssM) | 434601..438134 | + | 3534 | WP_012104359.1 | type VI secretion system membrane subunit TssM |
| T6CP008678 | TssA | YPK_RS23295 | 438259..439566 | + | 1308 | WP_012303456.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP002537 | TssI | YPK_RS02010 | 439588..441810 | + | 2223 | WP_012303457.1 | type VI secretion system tip protein VgrG |
| YPK_RS02015 | 441816..442274 | + | 459 | WP_002213383.1 | DcrB-related protein | ||
| YPK_RS02020 | 442267..446142 | + | 3876 | pseudogene | PAAR/RHS domain-containing protein | ||
| YPK_RS21475 | 446442..446861 | + | 420 | WP_012303459.1 | hypothetical protein | ||
| YPK_RS02035 | 447145..447390 | + | 246 | WP_012303460.1 | hypothetical protein | ||
| YPK_RS02040 | 447390..447878 | + | 489 | WP_012303461.1 | immunity 26/phosphotriesterase HocA family protein | ||
| YPK_RS21645 | 447924..448286 | - | 363 | WP_012303462.1 | SymE family type I addiction module toxin | ||
| YPK_RS02050 | 448283..448372 | - | 90 | pseudogene | type I addiction module toxin, SymE family | ||
| YPK_RS22990 | 448361..448450 | + | 90 | pseudogene | hypothetical protein | ||
| YPK_RS22995 | 448570..448644 | + | 75 | pseudogene | hypothetical protein | ||
| YPK_RS02055 | 448646..452215 | + | 3570 | pseudogene | RHS repeat protein | ||
| YPK_RS02060 | 452212..452493 | + | 282 | WP_011193190.1 | hypothetical protein | ||
| T6CP002538 | TssI | YPK_RS02065 | 452695..452916 | + | 222 | WP_012303466.1 | type IV secretion protein Rhs |
| YPK_RS21650 | 452917..453186 | - | 270 | WP_080513700.1 | SymE family type I addiction module toxin | ||
| YPK_RS02070 | 453206..454105 | - | 900 | WP_002210024.1 | sugar phosphate isomerase/epimerase | ||
| YPK_RS02075 | 454102..455232 | - | 1131 | WP_002210025.1 | Gfo/Idh/MocA family oxidoreductase | ||
| YPK_RS02080 | 455502..456368 | + | 867 | WP_012303467.1 | AraC family transcriptional regulator | ||
| YPK_RS02085 (rbsD) | 456528..457031 | - | 504 | WP_011193187.1 | D-ribose pyranase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0195 |
YPK_RS08345 (YpsR) | protein | QS regulatory pathway | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 1837676..1838413 (+) | 488140651 | T6SS transcripts (↓) |
| REG0196 |
YPK_RS03965 (YtbR) | protein | QS regulatory pathway | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 900476..901219 (+) | 488140447 | T6SS transcripts (↓) |
| REG0197 |
YPK_RS08350 (ypsI) | protein | QS regulatory pathway | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 1838406..1839050 (-) | 501053391 | T6SS transcripts (↓) |
| REG0198 |
YPK_RS03970 (ytbI) | protein | QS regulatory pathway | Yersinia pseudotuberculosis YPIII | chromosome (NC_010465) | 901200..901850 (-) | 488144695 | T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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