Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00372 experimental
T6SS type Type i4b
Strain Edwardsiella tarda EIB202
Replicon (RefSeq) chromosome (NC_013508)
Location 2555437..2575336
Function anti-eukaryotic; effector translocation; adherence; virulence
Comment Virulence in blue gourami fish; virulence in several other fish models; invasion of cultured carp epithelial cells.
References
[1] Wang X et al (2009) Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol. 27(3):469-77. [PudMed:19563898]
[2] Leung KY et al (2012) Edwardsiella tarda - virulence mechanisms of an emerging gastroenteritis pathogen. Microbes Infect. 14(1):26-34. [PudMed:21924375]
[3] Lv Y et al (2012) Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol. 157(1-2):190-9. [PudMed:22227416]
[4] Jobichen C et al (2010) Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One. 5(9):e12910. [PudMed:20886112]
[5] Yang M et al (2012) Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms. PLoS One. 7(5):e36987. [PudMed:22590641]
[6] Chakraborty S et al (2011) Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda. J Biol Chem. 286(45):39417-30. [PudMed:21953460]
[7] Zheng J et al (2007) Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol. 66(5):1192-206. [PudMed:17986187]
[8] Zhang J et al (2014) A new target for the old regulator: H-NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda. Lett Appl Microbiol. 59(5):557-564. [PudMed:25131176]
[9] Wang X et al (2010) Hemolysin EthA in Edwardsiella tarda is essential for fish invasion in vivo and in vitro and regulated by two-component system EsrA-EsrB and nucleoid protein HhaEt. Fish Shellfish Immunol. 29(6):1082-91. [PudMed:20832475]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentPAARTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number11111111111111


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Component ID
Component
Locus tag (Gene)
Coordinate
Strand
Size (bp)
NCBI ID
Product
ETAE_RS112152550717..2550998-282WP_012849252.1YfcL family protein
ETAE_RS112202551037..2551585-549WP_012849253.1elongation factor P hydroxylase
ETAE_RS112252551686..2552486-801WP_012849254.1TSUP family transporter
ETAE_RS112302552790..2554244-1455WP_071818527.1SH3 domain-containing protein
ETAE_RS182152554576..2555136+561WP_172454866.1hypothetical protein
T6CP003806TssBETAE_RS11240 (tssB)2555386..2555901+516WP_015683417.1type VI secretion system contractile sheath small subunit
T6CP003807TssCETAE_RS11245 (tssC)2555898..2557385+1488WP_012849259.1type VI secretion system contractile sheath large subunit
T6CP003808TssDETAE_RS112502557455..2557946+492WP_012849260.1type VI secretion system tube protein Hcp
ETAE_RS112552558046..2559248+1203WP_012849261.1hypothetical protein
T6CP003809TssEETAE_RS11260 (tssE)2559257..2559733+477WP_015461951.1type VI secretion system baseplate subunit TssE
Showing 1 to 10 of 25 rows rows per page
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Regulator ID
Locus tag (Gene)
Regulator type
Regulatory pathway
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Target (Regulation)
REG0206 experimentalETAE_2873 (RpoS)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)3025094..3026080 (-)502612732ETAE_0886 (esrB) promoter (↑)
REG0207 experimentalETAE_0035proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)35881..37008 (+)502609898ETAE_0886 (esrB) promoter (↑)
REG0208 experimentalETAE_0154 (hemB)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)159867..160889 (+)502610017ETAE_0886 (esrB) promoter (↑)
REG0209 experimentalETAE_0743 (cdsA)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)820052..820909 (+)502610607ETAE_0886 (esrB) promoter (↑)
REG0210 experimentalETAE_2082 (pyrF)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)2196136..2196858 (-)502611934ETAE_0886 (esrB) promoter (↑)
REG0211 experimentalETAE_1096 (dapA)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)1194778..1195659 (+)502610962ETAE_0886 (esrB) promoter (↑)
REG0212 experimentalETAE_2697 (cysS)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)2831230..2832615 (-)502612557ETAE_0886 (esrB) promoter (↑)
REG0213 experimentalETAE_1760proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (CP001135)1870377..1870535 (+)267984768ETAE_0886 (esrB) promoter (↑)
REG0214 experimentalETAE_1837proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (CP001135)1946159..1946284 (-)267984845ETAE_0886 (esrB) promoter (↑)
REG0215 experimentalETAE_1202 (ugd)proteinTCS regulatory pathwayEdwardsiella tarda EIB202chromosome (NC_013508)1306603..1307769 (+)502611067ETAE_0886 (esrB) promoter (↑)
Showing 1 to 10 of 42 rows rows per page

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Showing 1 to 4 of 4 rows

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Immunity protein ID
Locus tag (Gene)
Cognate effector
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
No matching records found

experimental Experimental investigation has been performed.
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Accessory protein ID
Locus tag (Gene)
Type            
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Related structure protein
Related effector
No matching records found