Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00372 ![]() |
T6SS type | Type i4b |
Strain | Edwardsiella tarda EIB202 |
Replicon (RefSeq) | chromosome (NC_013508) |
Location | 2555437..2575336 |
Function | anti-eukaryotic; effector translocation; adherence; virulence |
Comment | Virulence in blue gourami fish; virulence in several other fish models; invasion of cultured carp epithelial cells. |
References | [1] Wang X et al (2009) Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol. 27(3):469-77. [PudMed:19563898] [2] Leung KY et al (2012) Edwardsiella tarda - virulence mechanisms of an emerging gastroenteritis pathogen. Microbes Infect. 14(1):26-34. [PudMed:21924375] [3] Lv Y et al (2012) Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol. 157(1-2):190-9. [PudMed:22227416] [4] Jobichen C et al (2010) Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One. 5(9):e12910. [PudMed:20886112] [5] Yang M et al (2012) Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms. PLoS One. 7(5):e36987. [PudMed:22590641] [6] Chakraborty S et al (2011) Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda. J Biol Chem. 286(45):39417-30. [PudMed:21953460] [7] Zheng J et al (2007) Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol. 66(5):1192-206. [PudMed:17986187] [8] Zhang J et al (2014) A new target for the old regulator: H-NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda. Lett Appl Microbiol. 59(5):557-564. [PudMed:25131176] [9] Wang X et al (2010) Hemolysin EthA in Edwardsiella tarda is essential for fish invasion in vivo and in vitro and regulated by two-component system EsrA-EsrB and nucleoid protein HhaEt. Fish Shellfish Immunol. 29(6):1082-91. [PudMed:20832475] |

T6SS components and genome coordinates
Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |

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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
ETAE_RS11215 | 2550717..2550998 | - | 282 | WP_012849252.1 | YfcL family protein | ||
ETAE_RS11220 | 2551037..2551585 | - | 549 | WP_012849253.1 | elongation factor P hydroxylase | ||
ETAE_RS11225 | 2551686..2552486 | - | 801 | WP_012849254.1 | TSUP family transporter | ||
ETAE_RS11230 | 2552790..2554244 | - | 1455 | WP_071818527.1 | SH3 domain-containing protein | ||
ETAE_RS18215 | 2554576..2555136 | + | 561 | WP_172454866.1 | hypothetical protein | ||
T6CP003806 | TssB | ETAE_RS11240 (tssB) | 2555386..2555901 | + | 516 | WP_015683417.1 | type VI secretion system contractile sheath small subunit |
T6CP003807 | TssC | ETAE_RS11245 (tssC) | 2555898..2557385 | + | 1488 | WP_012849259.1 | type VI secretion system contractile sheath large subunit |
T6CP003808 | TssD | ETAE_RS11250 | 2557455..2557946 | + | 492 | WP_012849260.1 | type VI secretion system tube protein Hcp |
ETAE_RS11255 | 2558046..2559248 | + | 1203 | WP_012849261.1 | hypothetical protein | ||
T6CP003809 | TssE | ETAE_RS11260 (tssE) | 2559257..2559733 | + | 477 | WP_015461951.1 | type VI secretion system baseplate subunit TssE |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.


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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|---|
EFF01477 ![]() | ETAE_1303 (EseL) | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 1411812..1412027 (-) | 502611166 |
EFF01478 ![]() | ETAE_2136 (EseM) | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2248536..2248751 (+) | 502611987 |
EFF00478 ![]() | ETAE_RS18215 | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2554576..2555136 (+) | 269139773 |
EFF00479 ![]() | ETAE_RS11250 | - | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2557455..2557946 (+) | 269139776 |
Showing 1 to 4 of 4 rows


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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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No matching records found |