Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00372 |
T6SS type | Type i4b |
Strain | Edwardsiella tarda EIB202 |
Replicon (RefSeq) | chromosome (NC_013508) |
Location | 2555437..2575336 |
Function | anti-eukaryotic; effector translocation; adherence; virulence |
Comment | Virulence in blue gourami fish; virulence in several other fish models; invasion of cultured carp epithelial cells. |
References | [1] Wang X et al (2009) Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol. 27(3):469-77. [PudMed:19563898] [2] Leung KY et al (2012) Edwardsiella tarda - virulence mechanisms of an emerging gastroenteritis pathogen. Microbes Infect. 14(1):26-34. [PudMed:21924375] [3] Lv Y et al (2012) Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol. 157(1-2):190-9. [PudMed:22227416] [4] Jobichen C et al (2010) Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One. 5(9):e12910. [PudMed:20886112] [5] Yang M et al (2012) Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms. PLoS One. 7(5):e36987. [PudMed:22590641] [6] Chakraborty S et al (2011) Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda. J Biol Chem. 286(45):39417-30. [PudMed:21953460] [7] Zheng J et al (2007) Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol. 66(5):1192-206. [PudMed:17986187] [8] Zhang J et al (2014) A new target for the old regulator: H-NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda. Lett Appl Microbiol. 59(5):557-564. [PudMed:25131176] [9] Wang X et al (2010) Hemolysin EthA in Edwardsiella tarda is essential for fish invasion in vivo and in vitro and regulated by two-component system EsrA-EsrB and nucleoid protein HhaEt. Fish Shellfish Immunol. 29(6):1082-91. [PudMed:20832475] |
T6SS components and genome coordinates
Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
ETAE_RS11215 | 2550717..2550998 | - | 282 | WP_012849252.1 | YfcL family protein | ||
ETAE_RS11220 | 2551037..2551585 | - | 549 | WP_012849253.1 | elongation factor P hydroxylase | ||
ETAE_RS11225 | 2551686..2552486 | - | 801 | WP_012849254.1 | TSUP family transporter | ||
ETAE_RS11230 | 2552790..2554244 | - | 1455 | WP_071818527.1 | SH3 domain-containing protein | ||
ETAE_RS18215 | 2554576..2555136 | + | 561 | WP_172454866.1 | hypothetical protein | ||
T6CP003806 | TssB | ETAE_RS11240 (tssB) | 2555386..2555901 | + | 516 | WP_015683417.1 | type VI secretion system contractile sheath small subunit |
T6CP003807 | TssC | ETAE_RS11245 (tssC) | 2555898..2557385 | + | 1488 | WP_012849259.1 | type VI secretion system contractile sheath large subunit |
T6CP003808 | TssD | ETAE_RS11250 | 2557455..2557946 | + | 492 | WP_012849260.1 | type VI secretion system tube protein Hcp |
ETAE_RS11255 | 2558046..2559248 | + | 1203 | WP_012849261.1 | hypothetical protein | ||
T6CP003809 | TssE | ETAE_RS11260 (tssE) | 2559257..2559733 | + | 477 | WP_015461951.1 | type VI secretion system baseplate subunit TssE |
T6CP003810 | TssF | ETAE_RS11265 (tssF) | 2559737..2561578 | + | 1842 | WP_012849263.1 | type VI secretion system baseplate subunit TssF |
T6CP003811 | TssG | ETAE_RS11270 (tssG) | 2561575..2562600 | + | 1026 | WP_012849264.1 | type VI secretion system baseplate subunit TssG |
T6CP003812 | TssH | ETAE_RS11275 (tssH) | 2562752..2565331 | + | 2580 | WP_034168298.1 | type VI secretion system ATPase TssH |
T6CP003813 | TssI | ETAE_RS11280 | 2565331..2567316 | + | 1986 | WP_015461955.1 | type VI secretion system tip protein VgrG |
T6CP011796 | PAAR | ETAE_RS11285 | 2567411..2567713 | + | 303 | WP_012849267.1 | PAAR domain-containing protein |
T6CP003814 | TssA | ETAE_RS11290 (tssA) | 2567727..2568794 | + | 1068 | WP_012849268.1 | type VI secretion system protein TssA |
T6CP009342 | TssJ | ETAE_RS11295 | 2568781..2569422 | + | 642 | WP_012849269.1 | type VI secretion lipoprotein TssJ |
T6CP003815 | TssK | ETAE_RS11300 (tssK) | 2569522..2570910 | + | 1389 | WP_012849270.1 | type VI secretion system baseplate subunit TssK |
T6CP003816 | TssL | ETAE_RS11305 | 2570907..2571557 | + | 651 | WP_012849271.1 | DotU family type IV/VI secretion system protein |
T6CP003817 | TssM | ETAE_RS11310 | 2571554..2575336 | + | 3783 | WP_012849272.1 | type VI secretion system protein ImpL |
ETAE_RS11315 (mepA) | 2575468..2576286 | - | 819 | WP_034168301.1 | penicillin-insensitive murein endopeptidase | ||
ETAE_RS11320 (aroC) | 2576312..2577397 | - | 1086 | WP_012849274.1 | chorismate synthase | ||
ETAE_RS11325 (prmB) | 2577489..2578421 | - | 933 | WP_012849275.1 | 50S ribosomal protein L3 N(5)-glutamine methyltransferase | ||
ETAE_RS11330 (smrB) | 2578632..2579177 | + | 546 | WP_041692530.1 | endonuclease SmrB | ||
ETAE_RS11335 (sixA) | 2579228..2579704 | - | 477 | WP_012849277.1 | phosphohistidine phosphatase SixA |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|---|
EFF01477 | ETAE_1303 (EseL) | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 1411812..1412027 (-) | 502611166 |
EFF01478 | ETAE_2136 (EseM) | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2248536..2248751 (+) | 502611987 |
EFF00478 | ETAE_RS18215 | Tse | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2554576..2555136 (+) | 269139773 |
EFF00479 | ETAE_RS11250 | - | - | Edwardsiella tarda EIB202 | chromosome (NC_013508) | 2557455..2557946 (+) | 269139776 |
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.
Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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