Detailed information of regulator
Summary
| Regulator ID | REG0215  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | TCS regulatory pathway |
| KEGG pathway (determined by BlastKOALA) | Metabolic pathways (map01100); Biosynthesis of nucleotide sugars (map01250); Biosynthesis of cofactors (map01240); Pentose and glucuronate interconversions (map00040); Ascorbate and aldarate metabolism (map00053); Amino sugar and nucleotide sugar metabolism (map00520); O-Antigen nucleotide sugar biosynthesis (map00541) |
| Related T6SS | T6SS00372 (Type i4b) |
| Strain | Edwardsiella tarda EIB202 |
| Replicon | chromosome |
| Sequence | Protein sequence (389 a.a.); Nucleotide sequence (1167 bp) |
| Description | Putative repressors of esrB as identified by Tn-seq. |
| Reference |
External database links
| Locus tag (Gene) | ETAE_1202 (ugd) |
| Coordinates (Strand) | 1306603..1307769 (+) |
| NCBI ID | 502611067 |
| RefSeq | NC_013508 |
| Uniprot ID | D0ZFL3_EDWTE, A0A0H3DRP5_EDWTF |
| KEGG ID | etd:ETAF_1120, etr:ETAE_1202 |
| KEGG pathway (determined by BlastKOALA) | map01100; map01250; map01240; map00040; map00053; map00520; map00541 |
| PDB ID | - |
Target
| Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| ETAE_0886 (esrB) promoter | ↑ | - |
Pfam domain hit(s) of regulator
| Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| UDPG_MGDP_dh_N | PF03721.16 | 2.6e-31 | 1..168 |
| UDPG_MGDP_dh | PF00984.21 | 1e-26 | 192..281 |
| UDPG_MGDP_dh_C | PF03720.17 | 3.5e-06 | 301..375 |
Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
| Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-388 | MKIAISGTGYVGLSNGILLAQHHEVVALDIVAEKVEMLNRRQSPIVDKEIQEYLTHRSLNFRATLDKEEAYRGADFVIIATPTDYDPKSNYFNTASVEAVICDVLAINPAAVMIIKSTIPVGFTQQLRERLGIDNLIFSPEFLREGRALYDNLHPSRIVVGERSARAERFAALLQEGAIKQNIPTLLTDSTEAEAIKLFANTYLAMRVAYFNELDSYAEALGLNSRQIIEGVSLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYSSVPNNLIQAIVEANRTRKDFIADSIIARNPQVVGVYRLIMKSGSDNFRASSIQGIMKRIKAKGIKVVIFEPVMKEDSFFHSEVIRDLEQFKAMSDVIISNRMAPELDDVADKVYTRDIFGND |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
| Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.8936 | - | - |
Protein sequence of regulator: 389 a.a. .
>REG0215 NC_013508:1306603-1307769 [Edwardsiella tarda EIB202]
MKIAISGTGYVGLSNGILLAQHHEVVALDIVAEKVEMLNRRQSPIVDKEIQEYLTHRSLNFRATLDKEEAYRGADFVIIA
TPTDYDPKSNYFNTASVEAVICDVLAINPAAVMIIKSTIPVGFTQQLRERLGIDNLIFSPEFLREGRALYDNLHPSRIVV
GERSARAERFAALLQEGAIKQNIPTLLTDSTEAEAIKLFANTYLAMRVAYFNELDSYAEALGLNSRQIIEGVSLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYSSVPNNLIQAIVEANRTRKDFIADSIIARNPQVVGVYRLIMKSGSDNFRASSIQG
IMKRIKAKGIKVVIFEPVMKEDSFFHSEVIRDLEQFKAMSDVIISNRMAPELDDVADKVYTRDIFGND*
MKIAISGTGYVGLSNGILLAQHHEVVALDIVAEKVEMLNRRQSPIVDKEIQEYLTHRSLNFRATLDKEEAYRGADFVIIA
TPTDYDPKSNYFNTASVEAVICDVLAINPAAVMIIKSTIPVGFTQQLRERLGIDNLIFSPEFLREGRALYDNLHPSRIVV
GERSARAERFAALLQEGAIKQNIPTLLTDSTEAEAIKLFANTYLAMRVAYFNELDSYAEALGLNSRQIIEGVSLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYSSVPNNLIQAIVEANRTRKDFIADSIIARNPQVVGVYRLIMKSGSDNFRASSIQG
IMKRIKAKGIKVVIFEPVMKEDSFFHSEVIRDLEQFKAMSDVIISNRMAPELDDVADKVYTRDIFGND*
Nucleotide sequence of regulator: 1167 bp .
>REG0215 NC_013508:1306603-1307769 [Edwardsiella tarda EIB202]
ATGAAGATTGCGATTAGCGGTACGGGCTACGTCGGCCTGTCCAACGGAATTTTGCTGGCTCAGCATCATGAGGTCGTCGC
CCTGGATATCGTGGCGGAAAAGGTCGAGATGCTTAACCGGCGTCAGTCACCGATCGTGGATAAGGAGATCCAAGAGTACC
TCACTCACCGGTCCCTGAACTTCCGTGCGACGCTGGACAAGGAAGAGGCGTACCGCGGCGCAGATTTTGTCATCATTGCG
ACGCCGACCGACTATGATCCCAAGAGCAACTACTTTAACACCGCCAGCGTAGAGGCGGTGATCTGTGATGTGCTGGCGAT
CAATCCGGCGGCGGTGATGATCATCAAGTCGACCATTCCCGTCGGATTCACTCAGCAGCTGCGTGAGCGCCTGGGGATCG
ATAACCTGATCTTTTCGCCGGAGTTTCTGCGCGAGGGGCGGGCTCTGTATGACAACCTGCACCCGTCGCGTATCGTGGTC
GGTGAGCGCTCCGCGCGCGCGGAGCGCTTTGCTGCGCTGCTGCAGGAGGGGGCGATTAAGCAGAATATCCCGACCCTGCT
GACTGATTCGACGGAGGCAGAGGCGATCAAGCTGTTTGCCAACACTTACCTGGCGATGCGGGTCGCCTATTTTAACGAGC
TGGATAGCTATGCTGAGGCGCTGGGGCTCAACAGCCGTCAGATTATTGAGGGGGTTAGCCTCGATCCGCGTATCGGCAAC
CACTATAACAATCCTTCGTTTGGCTACGGCGGCTACTGTCTGCCGAAGGATACCAAGCAGCTCTTGGCCAACTACTCCTC
GGTGCCCAATAATCTGATCCAGGCGATTGTTGAGGCCAACCGTACGCGTAAAGACTTTATCGCCGACTCGATTATTGCGC
GTAATCCGCAGGTGGTGGGCGTGTACCGGCTGATCATGAAGAGCGGTTCGGATAACTTCCGCGCCTCCTCGATTCAGGGG
ATCATGAAGCGTATCAAGGCCAAGGGGATTAAAGTGGTGATCTTTGAGCCAGTGATGAAAGAGGATAGCTTCTTCCACTC
CGAGGTGATCCGTGACCTGGAGCAGTTCAAGGCGATGTCGGATGTGATCATCTCGAACCGCATGGCGCCGGAGCTGGATG
ATGTGGCGGACAAGGTCTACACCCGCGATATCTTTGGCAATGACTAA
ATGAAGATTGCGATTAGCGGTACGGGCTACGTCGGCCTGTCCAACGGAATTTTGCTGGCTCAGCATCATGAGGTCGTCGC
CCTGGATATCGTGGCGGAAAAGGTCGAGATGCTTAACCGGCGTCAGTCACCGATCGTGGATAAGGAGATCCAAGAGTACC
TCACTCACCGGTCCCTGAACTTCCGTGCGACGCTGGACAAGGAAGAGGCGTACCGCGGCGCAGATTTTGTCATCATTGCG
ACGCCGACCGACTATGATCCCAAGAGCAACTACTTTAACACCGCCAGCGTAGAGGCGGTGATCTGTGATGTGCTGGCGAT
CAATCCGGCGGCGGTGATGATCATCAAGTCGACCATTCCCGTCGGATTCACTCAGCAGCTGCGTGAGCGCCTGGGGATCG
ATAACCTGATCTTTTCGCCGGAGTTTCTGCGCGAGGGGCGGGCTCTGTATGACAACCTGCACCCGTCGCGTATCGTGGTC
GGTGAGCGCTCCGCGCGCGCGGAGCGCTTTGCTGCGCTGCTGCAGGAGGGGGCGATTAAGCAGAATATCCCGACCCTGCT
GACTGATTCGACGGAGGCAGAGGCGATCAAGCTGTTTGCCAACACTTACCTGGCGATGCGGGTCGCCTATTTTAACGAGC
TGGATAGCTATGCTGAGGCGCTGGGGCTCAACAGCCGTCAGATTATTGAGGGGGTTAGCCTCGATCCGCGTATCGGCAAC
CACTATAACAATCCTTCGTTTGGCTACGGCGGCTACTGTCTGCCGAAGGATACCAAGCAGCTCTTGGCCAACTACTCCTC
GGTGCCCAATAATCTGATCCAGGCGATTGTTGAGGCCAACCGTACGCGTAAAGACTTTATCGCCGACTCGATTATTGCGC
GTAATCCGCAGGTGGTGGGCGTGTACCGGCTGATCATGAAGAGCGGTTCGGATAACTTCCGCGCCTCCTCGATTCAGGGG
ATCATGAAGCGTATCAAGGCCAAGGGGATTAAAGTGGTGATCTTTGAGCCAGTGATGAAAGAGGATAGCTTCTTCCACTC
CGAGGTGATCCGTGACCTGGAGCAGTTCAAGGCGATGTCGGATGTGATCATCTCGAACCGCATGGCGCCGGAGCTGGATG
ATGTGGCGGACAAGGTCTACACCCGCGATATCTTTGGCAATGACTAA