Detailed information of component protein

Summary

Component ID	T6CP003806
Component protein type	TssB
T6SS ID (Type)	T6SS00372 (Type i4b)
Strain	Edwardsiella tarda EIB202
Replicon	chromosome
Sequence	Protein sequence (172 a.a.); Nucleotide sequence (516 bp)
Reference	[1] Yang M, Lv Y, Xiao J, et al. Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms. PLoS One. 2012;7(5):e36987. doi: 10.1371/journal.pone.0036987. Epub 2012 May 10. PMID: 22590641 [2] Lv Y, Xiao J, Liu Q, et al. Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol. 2012 May 25;157(1-2):190-9. doi: 10.1016/j.vetmic.2011.12.018. Epub 2011 Dec 22. PMID: 22227416 [3] Chakraborty S, Sivaraman J, Leung KY, et al. Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda. J Biol Chem. 2011 Nov 11;286(45):39417-30. doi: 10.1074/jbc.M111.295188. Epub 2011 Sep 27. PMID: 21953460 [4] Leung KY, Siame BA, Tenkink BJ, et al. Edwardsiella tarda - virulence mechanisms of an emerging gastroenteritis pathogen. Microbes Infect. 2012 Jan;14(1):26-34. doi: 10.1016/j.micinf.2011.08.005. Epub 2011 Sep 1. PMID: 21924375 [5] Jobichen C, Chakraborty S, Li M, et al. Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One. 2010 Sep 23;5(9):e12910. doi: 10.1371/journal.pone.0012910. PMID: 20886112 [6] Wang X, Wang Q, Xiao J, et al. Hemolysin EthA in Edwardsiella tarda is essential for fish invasion in vivo and in vitro and regulated by two-component system EsrA-EsrB and nucleoid protein HhaEt. Fish Shellfish Immunol. 2010 Dec;29(6):1082-91. doi: 10.1016/j.fsi.2010.08.025. Epub 2010 Sep 9. PMID: 20832475 [7] Wang X, Wang Q, Xiao J, et al. Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol. 2009 Sep;27(3):469-77. doi: 10.1016/j.fsi.2009.06.013. Epub 2009 Jun 27. PMID: 19563898 [8] Zheng J, Leung KY. Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol. 2007 Dec;66(5):1192-206. Epub 2007 Nov 6. PMID: 17986187 [9] Zhang J, Xiao J, Zhang Y, et al. A new target for the old regulator: H-NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda. Lett Appl Microbiol. 2014 Nov;59(5):557-64. doi: 10.1111/lam.12316. Epub 2014 Sep 12. PMID: 25131176

Experimental investigation has been performed on this T6SS

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External database links

Locus tag (Gene)	ETAE_RS11240
Coordinate (Strand)	2555386..2555901 (+)
NCBI ID	WP_015683417.1
RefSeq	NC_013508
Uniprot ID	A0A411H530_9GAMM, A0A0H3DWI7_EDWTF
KEGG ID	etd:ETAF_2199
PDB ID	-

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Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
T6SS_VipA	PF05591.14	3e-60	11..163

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-171	MANESKQHTLDRVRSPRVQITYDVEIGDAQEMKELPFVMGVLGDYSGQPATPLPKLKERKFVSIDRDNFNDVIKGVHPHLSFRTENTLSGDDSQLSVDLHFQSMADFTPERVAAQVEPLRKLMDIRSRLSDLKNKMYSNERLGEVLQGIIEDTEKLQSLGKETGFGEEKQP

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9963	-	-

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  Protein sequence: 172 a.a.    Download


  Nucleotide sequence: 516 bp    Download