Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01253  |
| T6SS type | Type i5 |
| Strain | Vibrio parahaemolyticus strain 12-009A/1335 |
| Replicon (RefSeq) | chromosome (NZ_MYFF01000494) |
| Location | 7384..30649 |
| Function | anti-bacterial |
| Comment | T6SS1 can secrete VGRG and the activity was required for the observed bactericidal activity at 30°C |
| References | [1] Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunan LM, Camilli A, Grishin NV, Salomon D, Orth K. et al (2017) Acute Hepatopancreatic Necrosis Disease-Causing Vibrio parahaemolyticus Strains Maintain an Antibacterial Type VI Secretion System with Versatile Effector Repertoires.. Appl Environ Microbiol. 83(13). [PudMed:28432099] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagF | TagH | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| B5C29_RS20050 | 5007..6140 | - | 1134 | 1189147650 | exonuclease SbcCD subunit D | ||
| B5C29_RS20055 | 6237..7079 | - | 843 | 1189147651 | transhydrogenase beta subunit | ||
| B5C29_RS20060 | 7080..7370 | - | 291 | 491641481 | PAAR domain-containing protein | ||
| T6CP015696 | TssI | B5C29_RS20065 (tssI) | 7384..9219 | - | 1836 | 646568991 | type VI secretion system tip protein VgrG |
| T6CP015697 | TssD | B5C29_RS20070 | 9277..9756 | - | 480 | 491518336 | type VI secretion system tube protein Hcp |
| T6CP015698 | TssH | B5C29_RS20075 (tssH) | 9962..12529 | - | 2568 | 686278494 | type VI secretion system ATPase TssH |
| T6CP015699 | TssG | B5C29_RS20080 (tssG) | 12540..13505 | - | 966 | 686278493 | type VI secretion system baseplate subunit TssG |
| T6CP015700 | TssF | B5C29_RS20085 (tssF) | 13502..15325 | - | 1824 | 646403521 | type VI secretion system baseplate subunit TssF |
| T6CP015701 | TssE | B5C29_RS20090 (tssE) | 15322..15786 | - | 465 | 505126202 | type VI secretion system baseplate subunit TssE |
| B5C29_RS20095 | 15795..16592 | - | 798 | 686278492 | protein of avirulence locus | ||
| T6CP015702 | TssC | B5C29_RS20100 (tssC) | 16603..18114 | - | 1512 | 686278491 | type VI secretion system contractile sheath large subunit |
| T6CP015703 | TssC | B5C29_RS20105 (tssC) | 18170..19663 | - | 1494 | 491606251 | type VI secretion system contractile sheath large subunit |
| T6CP015704 | TssB | B5C29_RS20110 (tssB) | 19663..20193 | - | 531 | 491606249 | type VI secretion system contractile sheath small subunit |
| T6CP015705 | TssA | B5C29_RS20115 (tssA) | 20209..21330 | - | 1122 | 659012108 | type VI secretion system protein TssA |
| B5C29_RS20120 | 21327..22115 | - | 789 | 491606245 | serine/threonine-protein phosphatase | ||
| T6CP015706 | TagF | B5C29_RS20125 (tagF) | 22126..22821 | - | 696 | 686278490 | type VI secretion system-associated protein TagF |
| T6CP015707 | TssM | B5C29_RS20130 (tssM) | 22803..26321 | - | 3519 | 686278489 | type VI secretion system membrane subunit TssM |
| T6CP015708 | TssL | B5C29_RS20135 (tssL) | 26337..27629 | - | 1293 | 516016889 | type VI secretion system protein TssL, long form |
| T6CP015709 | TssK | B5C29_RS20140 (tssK) | 27641..28966 | - | 1326 | 516016888 | type VI secretion system baseplate subunit TssK |
| T6CP015710 | TssJ | B5C29_RS20145 (tssJ) | 28988..29443 | - | 456 | 491606235 | type VI secretion system lipoprotein TssJ |
| T6CP015711 | TagH | B5C29_RS20150 (tagH) | 29453..30649 | - | 1197 | 491606233 | type VI secretion system-associated FHA domain protein TagH |
| B5C29_RS20160 | 30972..33113 | + | 2142 | 686278487 | serine/threonine protein kinase | ||
| B5C29_RS20165 | 33225..34760 | + | 1536 | 686278486 | response regulator | ||
| B5C29_RS20170 | 34763..35098 | + | 336 | 686278485 | hypothetical protein | ||
| B5C29_RS27745 | 35134..35325 | + | 192 | 639576797 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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