Detailed information of regulator
Summary
| Regulator ID | REG0288  |
| Regulator type | protein |
| Regulatory pathway (from literatures) | TCS-RR |
| KEGG pathway (determined by BlastKOALA) | - |
| Related T6SS | T6SS00002 (Type i1) |
| Strain | Vibrio cholerae O1 biovar El Tor str. N16961 |
| Replicon | chromosome |
| Sequence | Protein sequence (219 a.a.); Nucleotide sequence (657 bp) |
| Description | VxrB activates expression of the T6SS genes. Use Vibrio cholerae O1 biovar El Tor str. N16961 gene information as Vibrio cholerae O1 El Tor A1552 annotation |
| Reference |
External database links
| Locus tag (Gene) | VCA0566 (VxrB) |
| Coordinates (Strand) | 504728..505384 (+) |
| NCBI ID | 446737785 |
| RefSeq | NC_002506 |
| Uniprot ID | A0A0K9UPH6_VIBCL, A0A0F4FFH1_VIBCL |
| KEGG ID | vcq:EN18_01245 |
| KEGG pathway (determined by BlastKOALA) | - |
| PDB ID | - |
Target
| Target | Regulation (↓/↑) | Target sequence |
|---|---|---|
| Unknown | ↑ | - |
Pfam domain hit(s) of regulator
| Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| Trans_reg_C | PF00486.30 | 6.2e-24 | 145..216 |
| Response_reg | PF00072.26 | 4.4e-17 | 6..112 |
Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
| Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-218 | VKQTLLLVEDDKNLADGLLVSLEQAGYDCLHAETIADVKQHWDKADLVILDRQLPDGDSVQHLMDWKKIKDIPVILLTALVTVKDKVTGLDAGANDYLTKPFAEAELFARIRAQLRSPDSGQDDSKVVTSNLTIDKATREVFFNGESITLTRTEFDLLLFLASNLGRVFTRDELLDHVWGYNHFPTTRTVDTHVLQLRQKLPGLEIETLRGVGYKMKA |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
| Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.9950 | - | - |
Protein sequence of regulator: 219 a.a. .
>REG0288 NC_002506:504728-505384 [Vibrio cholerae O1 biovar El Tor str. N16961]
VKQTLLLVEDDKNLADGLLVSLEQAGYDCLHAETIADVKQHWDKADLVILDRQLPDGDSVQHLMDWKKIKDIPVILLTAL
VTVKDKVTGLDAGANDYLTKPFAEAELFARIRAQLRSPDSGQDDSKVVTSNLTIDKATREVFFNGESITLTRTEFDLLLF
LASNLGRVFTRDELLDHVWGYNHFPTTRTVDTHVLQLRQKLPGLEIETLRGVGYKMKA*
VKQTLLLVEDDKNLADGLLVSLEQAGYDCLHAETIADVKQHWDKADLVILDRQLPDGDSVQHLMDWKKIKDIPVILLTAL
VTVKDKVTGLDAGANDYLTKPFAEAELFARIRAQLRSPDSGQDDSKVVTSNLTIDKATREVFFNGESITLTRTEFDLLLF
LASNLGRVFTRDELLDHVWGYNHFPTTRTVDTHVLQLRQKLPGLEIETLRGVGYKMKA*
Nucleotide sequence of regulator: 657 bp .
>REG0288 NC_002506:504728-505384 [Vibrio cholerae O1 biovar El Tor str. N16961]
GTGAAACAGACACTGCTTCTCGTTGAAGATGATAAAAACCTCGCTGACGGTCTACTCGTCAGTTTAGAGCAAGCCGGTTA
TGACTGTTTACATGCAGAAACGATCGCAGATGTGAAACAGCATTGGGACAAGGCGGATCTCGTTATCCTTGATCGCCAAC
TGCCTGATGGTGATTCTGTACAGCATCTAATGGATTGGAAAAAAATTAAAGATATCCCAGTGATTCTTTTAACTGCATTG
GTCACAGTAAAAGACAAAGTGACTGGCCTTGATGCAGGCGCAAACGACTATCTCACTAAACCTTTTGCAGAAGCTGAGCT
GTTTGCACGTATCCGCGCACAGCTGCGCTCACCAGATAGTGGGCAAGATGACAGTAAAGTGGTGACGTCTAACTTAACAA
TTGATAAAGCGACTCGTGAAGTTTTCTTCAATGGCGAATCGATCACCCTAACTCGAACCGAGTTTGATTTACTGCTCTTT
TTAGCGAGTAATTTAGGCCGAGTATTTACTCGCGATGAATTACTGGATCACGTATGGGGATATAACCATTTCCCGACGAC
GCGCACCGTAGATACTCACGTTTTGCAGCTGCGCCAAAAGTTGCCTGGGCTTGAAATTGAAACGCTACGCGGTGTTGGTT
ACAAAATGAAAGCGTGA
GTGAAACAGACACTGCTTCTCGTTGAAGATGATAAAAACCTCGCTGACGGTCTACTCGTCAGTTTAGAGCAAGCCGGTTA
TGACTGTTTACATGCAGAAACGATCGCAGATGTGAAACAGCATTGGGACAAGGCGGATCTCGTTATCCTTGATCGCCAAC
TGCCTGATGGTGATTCTGTACAGCATCTAATGGATTGGAAAAAAATTAAAGATATCCCAGTGATTCTTTTAACTGCATTG
GTCACAGTAAAAGACAAAGTGACTGGCCTTGATGCAGGCGCAAACGACTATCTCACTAAACCTTTTGCAGAAGCTGAGCT
GTTTGCACGTATCCGCGCACAGCTGCGCTCACCAGATAGTGGGCAAGATGACAGTAAAGTGGTGACGTCTAACTTAACAA
TTGATAAAGCGACTCGTGAAGTTTTCTTCAATGGCGAATCGATCACCCTAACTCGAACCGAGTTTGATTTACTGCTCTTT
TTAGCGAGTAATTTAGGCCGAGTATTTACTCGCGATGAATTACTGGATCACGTATGGGGATATAACCATTTCCCGACGAC
GCGCACCGTAGATACTCACGTTTTGCAGCTGCGCCAAAAGTTGCCTGGGCTTGAAATTGAAACGCTACGCGGTGTTGGTT
ACAAAATGAAAGCGTGA