Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
T6SS ID | T6SS00157 ![]() |
T6SS type | Type i1 |
Strain | Aeromonas hydrophila subsp. hydrophila ATCC 7966 |
Replicon (RefSeq) | chromosome (NC_008570) |
Location | 1984799..2036268 |
Function | - |
Comment | This T6SS can secrete HCP. |
References | [1] Wang N et al (2015) Protective efficacy of recombinant hemolysin co-regulated protein (Hcp) of Aeromonas hydrophila in common carp (Cyprinus carpio). Fish Shellfish Immunol. 46(2):297-304. [PudMed:26093203] [2] Suarez G et al (2010) A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin. J Bacteriol. 192(1):155-68. [PudMed:19880608] [3] Sha J et al (2013) Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis. Microbiology. 159(Pt 6):1120-35. [PudMed:23519162] [4] Bernard CS et al (2011) Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol. 193(9):2158-67. [PudMed:21378190] [5] Khajanchi BK et al (2009) N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology. 155(Pt 11):3518-31. [PudMed:19729404] [6] Suarez G et al (2010) Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells. Microbiology. 156(Pt 12):3678-88. [PudMed:20798163] [7] Suarez G et al (2008) Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microb Pathog. 44(4):344-61. [PudMed:18037263] |

T6SS components and genome coordinates
Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 |

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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
---|---|---|---|---|---|---|---|
AHA_RS09135 (rrtA) | 1980299..1980856 | - | 558 | WP_011705695.1 | rhombosortase | ||
AHA_RS09140 | 1980807..1981493 | + | 687 | WP_011705696.1 | DTW domain-containing protein | ||
AHA_RS09145 (queC) | 1981516..1982223 | + | 708 | WP_011705697.1 | 7-cyano-7-deazaguanine synthase QueC | ||
AHA_RS09150 (queE) | 1982285..1982956 | + | 672 | WP_045791049.1 | 7-carboxy-7-deazaguanine synthase QueE | ||
AHA_RS09155 | 1982958..1983188 | + | 231 | WP_011705699.1 | DUF3820 family protein | ||
AHA_RS09160 | 1983185..1983748 | + | 564 | WP_011705700.1 | cob(I)yrinic acid a,c-diamide adenosyltransferase | ||
AHA_RS09165 | 1983815..1984219 | - | 405 | WP_011705701.1 | H-NS histone family protein | ||
AHA_RS09170 | 1984799..1986379 | + | 1581 | WP_011705702.1 | Na+/H+ antiporter NhaC family protein | ||
AHA_RS09175 | 1986466..1987047 | + | 582 | WP_011705703.1 | thymidine kinase | ||
AHA_RS09180 | 1987116..1988453 | - | 1338 | WP_011705704.1 | flavohemoglobin expression-modulating QEGLA motif protein |
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.


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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
---|---|---|---|---|---|---|---|---|
REG0353 ![]() | AHA_1842 (VasH) | protein | QS regulatory pathway | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | chromosome (NC_008570) | 2010521..2012059 (+) | 117617496 | T6SS gene cluster promoter (PAHA1826) (↓) |
REG0354 ![]() | AHA_3923 (rpoN) | protein | Global regulator | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | chromosome (NC_008570) | 4350676..4352115 (-) | 117618923 | T6SS gene cluster promoter (PAHA1826) (↓) |
Showing 1 to 2 of 2 rows


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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|---|
EFF00200 ![]() | AHA_RS05640 (VgrG1) | Tre | - | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | chromosome (NC_008570) | 1212752..1215535 (+) | 117619461 |
EFF00201 ![]() | AHA_RS09205 (VgrG2) | - | - | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | chromosome (NC_008570) | 1991311..1993542 (+) | 117621074 |
EFF00202 ![]() | AHA_RS09310 (VgrG3) | - | - | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | chromosome (NC_008570) | 2019669..2021714 (+) | 117620092 |
Showing 1 to 3 of 3 rows


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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
---|---|---|---|---|---|---|
No matching records found |

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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
---|---|---|---|---|---|---|---|---|
No matching records found |