Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00157 experimental
T6SS type Type i1
Strain Aeromonas hydrophila subsp. hydrophila ATCC 7966
Replicon (RefSeq) chromosome (NC_008570)
Location 1984799..2036268
Function -
Comment This T6SS can secrete HCP.
References
[1] Wang N et al (2015) Protective efficacy of recombinant hemolysin co-regulated protein (Hcp) of Aeromonas hydrophila in common carp (Cyprinus carpio). Fish Shellfish Immunol. 46(2):297-304. [PudMed:26093203]
[2] Suarez G et al (2010) A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin. J Bacteriol. 192(1):155-68. [PudMed:19880608]
[3] Sha J et al (2013) Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis. Microbiology. 159(Pt 6):1120-35. [PudMed:23519162]
[4] Bernard CS et al (2011) Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol. 193(9):2158-67. [PudMed:21378190]
[5] Khajanchi BK et al (2009) N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology. 155(Pt 11):3518-31. [PudMed:19729404]
[6] Suarez G et al (2010) Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells. Microbiology. 156(Pt 12):3678-88. [PudMed:20798163]
[7] Suarez G et al (2008) Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microb Pathog. 44(4):344-61. [PudMed:18037263]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentFHAPAARTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number112111111221111


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Component ID
Component
Locus tag (Gene)
Coordinate
Strand
Size (bp)
NCBI ID
Product
AHA_RS09135 (rrtA)1980299..1980856-558WP_011705695.1rhombosortase
AHA_RS091401980807..1981493+687WP_011705696.1DTW domain-containing protein
AHA_RS09145 (queC)1981516..1982223+708WP_011705697.17-cyano-7-deazaguanine synthase QueC
AHA_RS09150 (queE)1982285..1982956+672WP_045791049.17-carboxy-7-deazaguanine synthase QueE
AHA_RS091551982958..1983188+231WP_011705699.1DUF3820 family protein
AHA_RS091601983185..1983748+564WP_011705700.1cob(I)yrinic acid a,c-diamide adenosyltransferase
AHA_RS091651983815..1984219-405WP_011705701.1H-NS histone family protein
AHA_RS091701984799..1986379+1581WP_011705702.1Na+/H+ antiporter NhaC family protein
AHA_RS091751986466..1987047+582WP_011705703.1thymidine kinase
AHA_RS091801987116..1988453-1338WP_011705704.1flavohemoglobin expression-modulating QEGLA motif protein
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flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Regulator ID
Locus tag (Gene)
Regulator type
Regulatory pathway
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Target (Regulation)
REG0353 experimentalAHA_1842 (VasH)proteinQS regulatory pathwayAeromonas hydrophila subsp. hydrophila ATCC 7966chromosome (NC_008570)2010521..2012059 (+)117617496T6SS gene cluster promoter (PAHA1826) (↓)
REG0354 experimentalAHA_3923 (rpoN)proteinGlobal regulatorAeromonas hydrophila subsp. hydrophila ATCC 7966chromosome (NC_008570)4350676..4352115 (-)117618923T6SS gene cluster promoter (PAHA1826) (↓)
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experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Showing 1 to 3 of 3 rows

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
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Immunity protein ID
Locus tag (Gene)
Cognate effector
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
No matching records found

experimental Experimental investigation has been performed.
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Accessory protein ID
Locus tag (Gene)
Type            
Organism                
Replicon (Accession)
Coordinates (Strand)
NCBI ID
Related structure protein
Related effector
No matching records found