Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00303  |
| T6SS type | Type i1 |
| Strain | Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
| Replicon (RefSeq) | chromosome (NC_011274) |
| Location | 1114451..1137704 |
| Function | anti-eukaryotic |
| Comment | Colonisation of chicken, ileum, caeca, liver and spleen. |
| References | [1] Silva CA et al (2012) Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 80(2):839-49. [PudMed:22083712] [2] Pezoa D et al (2013) The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken. PLoS One. 8(5):e63917. [PudMed:23691117] [3] Blondel CJ et al (2009) Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 0.6625. [PudMed:19653904] [4] Blondel CJ et al (2010) Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 5(7):e11724. [PudMed:20661437] [5] Blondel CJ et al (2013) The Type VI Secretion System encoded in SPI-19 is required for Salmonella Gallinarum survival within infected macrophages. Infect Immun. 81(4):1207-20. [PudMed:23357385] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssB | TssC | TssD | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| SG_RS05180 | 1109709..1110815 | + | 1107 | pseudogene | Gfo/Idh/MocA family oxidoreductase | ||
| SG_RS05185 | 1110982..1111275 | - | 294 | WP_000114401.1 | hypothetical protein | ||
| SG_RS05190 | 1111306..1111524 | + | 219 | WP_000880617.1 | hypothetical protein | ||
| SG_RS05200 | 1112125..1112583 | - | 459 | WP_000623372.1 | DUF1311 domain-containing protein | ||
| SG_RS05205 | 1112707..1113078 | - | 372 | WP_001227393.1 | hypothetical protein | ||
| SG_RS22830 | 1113087..1113530 | - | 444 | WP_071590439.1 | hypothetical protein | ||
| SG_RS05210 | 1113546..1114418 | - | 873 | WP_000248210.1 | LysM peptidoglycan-binding domain-containing protein | ||
| T6CP008716 | TssD | SG_RS05215 | 1114451..1114930 | - | 480 | WP_001284964.1 | Hcp family type VI secretion system effector |
| SG_RS05220 | 1114918..1116321 | - | 1404 | WP_000076069.1 | type VI secretion system ImpA family N-terminal domain-containing protein | ||
| SG_RS05225 (tssM) | 1116332..1119793 | - | 3462 | WP_001137108.1 | type VI secretion system membrane subunit TssM | ||
| SG_RS05230 (tssA) | 1119872..1121284 | - | 1413 | pseudogene | type VI secretion system protein TssA | ||
| SG_RS05235 (tagO) | 1121286..1122023 | - | 738 | WP_000089148.1 | type VI secretion system-associated protein TagO | ||
| T6CP003083 | TssH | SG_RS05240 | 1122020..1124683 | - | 2664 | WP_000614300.1 | AAA family ATPase |
| T6CP003084 | TssL | SG_RS05245 | 1124696..1125454 | - | 759 | WP_000343978.1 | type IVB secretion system protein IcmH/DotU |
| T6CP003085 | TssK | SG_RS05250 (tssK) | 1125459..1126790 | - | 1332 | WP_000246454.1 | type VI secretion system baseplate subunit TssK |
| SG_RS05255 (tssJ) | 1126793..1127296 | - | 504 | WP_124084121.1 | type VI secretion system lipoprotein TssJ | ||
| SG_RS05260 (tagH) | 1127323..1128609 | - | 1287 | WP_000796942.1 | type VI secretion system-associated FHA domain protein TagH | ||
| SG_RS05265 (tssG) | 1128634..1129722 | - | 1089 | WP_000509049.1 | type VI secretion system baseplate subunit TssG | ||
| SG_RS05270 (tssF) | 1129686..1131539 | - | 1854 | WP_000393869.1 | type VI secretion system baseplate subunit TssF | ||
| SG_RS05275 (tssE) | 1131544..1131960 | - | 417 | WP_000611698.1 | type VI secretion system baseplate subunit TssE | ||
| T6CP003089 | TssC | SG_RS05280 (tssC) | 1131957..1133429 | - | 1473 | WP_000058001.1 | type VI secretion system contractile sheath large subunit |
| SG_RS05290 (tssB) | 1133720..1134223 | - | 504 | WP_000031252.1 | type VI secretion system contractile sheath small subunit | ||
| T6CP008719 | TssD | SG_RS05300 | 1134853..1135371 | + | 519 | WP_001142966.1 | Hcp family type VI secretion system effector |
| T6CP003091 | TssI | SG_RS05305 | 1135593..1137704 | + | 2112 | WP_000103449.1 | type VI secretion system tip protein VgrG |
| SG_RS05310 | 1137806..1141606 | + | 3801 | pseudogene | RHS repeat protein | ||
| SG_RS24050 | 1141623..1142204 | + | 582 | WP_001675352.1 | hypothetical protein | ||
| SG_RS05320 | 1142197..1142601 | + | 405 | WP_000622532.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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