Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00303 experimental
T6SS type Type i1
Strain Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Replicon (RefSeq) chromosome (NC_011274)
Location 1114451..1137704
Function anti-eukaryotic
Comment Colonisation of chicken, ileum, caeca, liver and spleen.
References
[1] Silva CA et al (2012) Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 80(2):839-49. [PudMed:22083712]
[2] Pezoa D et al (2013) The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken. PLoS One. 8(5):e63917. [PudMed:23691117]
[3] Blondel CJ et al (2009) Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 0.6625. [PudMed:19653904]
[4] Blondel CJ et al (2010) Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 5(7):e11724. [PudMed:20661437]
[5] Blondel CJ et al (2013) The Type VI Secretion System encoded in SPI-19 is required for Salmonella Gallinarum survival within infected macrophages. Infect Immun. 81(4):1207-20. [PudMed:23357385]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentFHAPAARTssATssBTssCTssDTssFTssGTssHTssITssJTssKTssLTssM
Number11211211111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
SG_RS05180 1109709..1110815 + 1107 pseudogene Gfo/Idh/MocA family oxidoreductase
SG_RS05185 1110982..1111275 - 294 WP_000114401.1 hypothetical protein
SG_RS05190 1111306..1111524 + 219 WP_000880617.1 hypothetical protein
SG_RS05200 1112125..1112583 - 459 WP_000623372.1 DUF1311 domain-containing protein
SG_RS05205 1112707..1113078 - 372 WP_001227393.1 hypothetical protein
SG_RS22830 1113087..1113530 - 444 WP_071590439.1 hypothetical protein
SG_RS05210 1113546..1114418 - 873 WP_000248210.1 LysM peptidoglycan-binding domain-containing protein
T6CP008716 TssD SG_RS05215 1114451..1114930 - 480 WP_001284964.1 Hcp family type VI secretion system effector
SG_RS05220 1114918..1116321 - 1404 WP_000076069.1 type VI secretion system ImpA family N-terminal domain-containing protein
SG_RS05225 (tssM) 1116332..1119793 - 3462 WP_001137108.1 type VI secretion system membrane subunit TssM
SG_RS05230 (tssA) 1119872..1121284 - 1413 pseudogene type VI secretion system protein TssA
SG_RS05235 (tagO) 1121286..1122023 - 738 WP_000089148.1 type VI secretion system-associated protein TagO
T6CP003083 TssH SG_RS05240 1122020..1124683 - 2664 WP_000614300.1 AAA family ATPase
T6CP003084 TssL SG_RS05245 1124696..1125454 - 759 WP_000343978.1 type IVB secretion system protein IcmH/DotU
T6CP003085 TssK SG_RS05250 (tssK) 1125459..1126790 - 1332 WP_000246454.1 type VI secretion system baseplate subunit TssK
SG_RS05255 (tssJ) 1126793..1127296 - 504 WP_124084121.1 type VI secretion system lipoprotein TssJ
SG_RS05260 (tagH) 1127323..1128609 - 1287 WP_000796942.1 type VI secretion system-associated FHA domain protein TagH
SG_RS05265 (tssG) 1128634..1129722 - 1089 WP_000509049.1 type VI secretion system baseplate subunit TssG
SG_RS05270 (tssF) 1129686..1131539 - 1854 WP_000393869.1 type VI secretion system baseplate subunit TssF
SG_RS05275 (tssE) 1131544..1131960 - 417 WP_000611698.1 type VI secretion system baseplate subunit TssE
T6CP003089 TssC SG_RS05280 (tssC) 1131957..1133429 - 1473 WP_000058001.1 type VI secretion system contractile sheath large subunit
SG_RS05290 (tssB) 1133720..1134223 - 504 WP_000031252.1 type VI secretion system contractile sheath small subunit
T6CP008719 TssD SG_RS05300 1134853..1135371 + 519 WP_001142966.1 Hcp family type VI secretion system effector
T6CP003091 TssI SG_RS05305 1135593..1137704 + 2112 WP_000103449.1 type VI secretion system tip protein VgrG
SG_RS05310 1137806..1141606 + 3801 pseudogene RHS repeat protein
SG_RS24050 1141623..1142204 + 582 WP_001675352.1 hypothetical protein
SG_RS05320 1142197..1142601 + 405 WP_000622532.1 hypothetical protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector