Detailed information of component protein


Summary

Component ID T6CP003089
Component protein type TssC
T6SS ID (Type) T6SS00303 experimental (Type i1)
Strain Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Replicon chromosome
Sequence Protein sequence (491 a.a.); Nucleotide sequence (1473 bp)
Reference
[1] Blondel CJ, Yang HJ, Castro B, et al. Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 2010 Jul 22;5(7):e11724. doi: 10.1371/journal.pone.0011724. PMID: 20661437
[2] Blondel CJ, Jiménez JC, Contreras I, et al. Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 2009 Aug 4;10:354. doi: 10.1186/1471-2164-10-354. PMID: 19653904
[3] Silva CA, Blondel CJ, Quezada CP, et al. Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 2012 Feb;80(2):839-49. doi: 10.1128/IAI.05497-11. Epub 2011 Nov 14. PMID: 22083712
[4] Blondel CJ, Jiménez JC, Leiva LE, et al. The type VI secretion system encoded in Salmonella pathogenicity island 19 is required for Salmonella enterica serotype Gallinarum survival within infected macrophages. Infect Immun. 2013 Apr;81(4):1207-20. doi: 10.1128/IAI.01165-12. Epub 2013 Jan 28. PMID: 23357385
[5] Pezoa D, Yang HJ, Blondel CJ, et al. The type VI secretion system encoded in SPI-6 plays a role in gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken. PLoS One. 2013 May 14;8(5):e63917. doi: 10.1371/journal.pone.0063917. Print 2013. PMID: 23691117
experimental Experimental investigation has been performed on this T6SS
External database links

Locus tag (Gene) SG_RS05280
Coordinate (Strand) 1131957..1133429 (-)
NCBI ID 445980146
RefSeq NC_011274
Uniprot ID B5R7C1_SALG2
KEGG ID seg:SG1041
PDB ID -
Pfam domain hit(s)

Domain Pfam ID E-value Aligned region
VipB PF05943.14 3.1e-123 69..368
VipB_2 PF18945.2 2.2e-42 378..488
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-490 MSLQEEELVSTRTEQGSHAPSLLDEIMAQTRIQPGADGYDIARQGVTAFIASLLQSTSSAEPVNKLAVDSMIADIDARISRQMDAIIHAPQFQQLESFWRSMKALVDRVDFRENIKVHVLHVTKAELLEDFEFAPEITQSGFYKHVYSSGFGQFGGEPIAAVLGAYEFKNTTPDMKLLNYVSAVGAMAHAPFLSSVSPEFMGLKSWTELPNIKDLYAIFEGPAYTKWRALRDSEDSRYLGLTAPRFLLRQPYSATENPIKSFNYAEDVSHSHEHYLWGNTAWMLASNIADSFAKYRWAPNIIGPQSGGAVKDLPVHLYESMGQIQAKIPTEVLITDRREFELAEEGFITLTMRKNSDNAAFFSANSVQKPKHFPGKDAETNYKLGTQLPYLFIINRLAHYIKVLQREQLGSWKERSDLERELNIWVRQYVADQENPPADVRSRKPLRGAKVEVLDVDGEPGWYQVAISARPHFKYMGASFELSLVGRLDK


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9397 - -


  Protein sequence: 491 a.a.    

>T6CP003089 NC_011274:c1133429-1131957 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] [TssC]
MSLQEEELVSTRTEQGSHAPSLLDEIMAQTRIQPGADGYDIARQGVTAFIASLLQSTSSAEPVNKLAVDSMIADIDARIS
RQMDAIIHAPQFQQLESFWRSMKALVDRVDFRENIKVHVLHVTKAELLEDFEFAPEITQSGFYKHVYSSGFGQFGGEPIA
AVLGAYEFKNTTPDMKLLNYVSAVGAMAHAPFLSSVSPEFMGLKSWTELPNIKDLYAIFEGPAYTKWRALRDSEDSRYLG
LTAPRFLLRQPYSATENPIKSFNYAEDVSHSHEHYLWGNTAWMLASNIADSFAKYRWAPNIIGPQSGGAVKDLPVHLYES
MGQIQAKIPTEVLITDRREFELAEEGFITLTMRKNSDNAAFFSANSVQKPKHFPGKDAETNYKLGTQLPYLFIINRLAHY
IKVLQREQLGSWKERSDLERELNIWVRQYVADQENPPADVRSRKPLRGAKVEVLDVDGEPGWYQVAISARPHFKYMGASF
ELSLVGRLDK*

  Nucleotide sequence: 1473 bp    

>T6CP003089 NC_011274:c1133429-1131957 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] [TssC]
ATGTCTTTACAGGAAGAAGAACTTGTTTCCACCCGCACTGAACAGGGAAGCCATGCCCCGTCGTTGCTTGATGAAATCAT
GGCACAAACCCGTATCCAGCCCGGCGCTGACGGTTATGATATTGCCCGTCAGGGCGTAACGGCTTTTATTGCCAGCCTCC
TGCAATCCACTTCATCTGCAGAACCCGTAAACAAACTGGCCGTGGACAGCATGATTGCGGACATCGACGCCCGTATCAGC
CGTCAGATGGATGCTATTATTCACGCCCCTCAGTTTCAGCAACTGGAGTCGTTCTGGCGTTCAATGAAAGCGCTGGTCGA
TCGCGTTGATTTTCGTGAGAATATTAAGGTGCATGTCCTCCATGTCACCAAAGCGGAATTGCTGGAAGATTTCGAGTTCG
CGCCGGAGATTACCCAGTCCGGCTTCTATAAGCATGTTTATTCCAGCGGGTTTGGGCAGTTTGGCGGCGAACCGATTGCG
GCTGTGCTGGGCGCATATGAGTTCAAAAATACCACGCCGGATATGAAGCTGCTGAACTATGTCAGCGCCGTCGGCGCAAT
GGCTCACGCGCCGTTCCTTTCTTCCGTGTCGCCGGAGTTTATGGGCCTGAAATCATGGACCGAGCTGCCCAATATCAAGG
ATCTCTACGCCATTTTTGAAGGTCCGGCCTACACAAAATGGCGCGCCCTGCGTGATTCCGAAGATTCCCGCTACCTGGGA
CTGACCGCGCCGCGTTTTCTGCTTCGCCAGCCCTATTCCGCGACCGAAAACCCGATTAAAAGCTTCAACTACGCCGAAGA
TGTGAGCCACAGCCACGAGCATTATTTGTGGGGCAATACCGCCTGGATGCTGGCCAGTAATATAGCCGATTCGTTCGCGA
AATACCGGTGGGCGCCCAATATTATCGGGCCGCAGAGCGGCGGCGCAGTAAAAGATCTGCCGGTACATTTATATGAGTCA
ATGGGGCAGATTCAGGCCAAGATCCCGACGGAGGTGTTGATCACCGACCGCCGTGAGTTCGAGCTGGCCGAAGAGGGGTT
CATCACCCTGACCATGCGTAAAAACAGCGATAATGCGGCGTTTTTCTCGGCTAACAGCGTTCAGAAACCCAAGCATTTTC
CGGGCAAAGACGCCGAGACCAACTACAAGCTGGGTACGCAGTTGCCTTATCTGTTCATTATTAACCGCCTCGCGCACTAC
ATTAAGGTGCTGCAACGCGAGCAGCTTGGGTCGTGGAAAGAGAGAAGCGATCTGGAGCGGGAGCTGAATATTTGGGTGCG
CCAGTATGTCGCCGATCAGGAGAATCCGCCTGCTGATGTCCGCAGCCGTAAGCCGCTGCGTGGCGCTAAAGTGGAGGTGC
TGGATGTGGACGGCGAGCCGGGCTGGTATCAGGTGGCGATTTCCGCAAGGCCGCACTTTAAATATATGGGCGCGTCGTTT
GAATTGTCTTTAGTCGGACGGTTAGATAAGTGA