Detailed information of component protein


Summary

Component ID T6CP008719
Component protein type TssD
T6SS ID (Type) T6SS00303 experimental (Type i1)
Strain Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Replicon chromosome
Sequence Protein sequence (173 a.a.); Nucleotide sequence (519 bp)
Reference
[1] Blondel CJ, Yang HJ, Castro B, et al. Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 2010 Jul 22;5(7):e11724. doi: 10.1371/journal.pone.0011724. PMID: 20661437
[2] Blondel CJ, Jiménez JC, Contreras I, et al. Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 2009 Aug 4;10:354. doi: 10.1186/1471-2164-10-354. PMID: 19653904
[3] Silva CA, Blondel CJ, Quezada CP, et al. Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 2012 Feb;80(2):839-49. doi: 10.1128/IAI.05497-11. Epub 2011 Nov 14. PMID: 22083712
[4] Blondel CJ, Jiménez JC, Leiva LE, et al. The type VI secretion system encoded in Salmonella pathogenicity island 19 is required for Salmonella enterica serotype Gallinarum survival within infected macrophages. Infect Immun. 2013 Apr;81(4):1207-20. doi: 10.1128/IAI.01165-12. Epub 2013 Jan 28. PMID: 23357385
[5] Pezoa D, Yang HJ, Blondel CJ, et al. The type VI secretion system encoded in SPI-6 plays a role in gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken. PLoS One. 2013 May 14;8(5):e63917. doi: 10.1371/journal.pone.0063917. Print 2013. PMID: 23691117
experimental Experimental investigation has been performed on this T6SS
External database links

Locus tag (Gene) SG_RS05300
Coordinate (Strand) 1134853..1135371 (+)
NCBI ID 447065710
RefSeq NC_011274
Uniprot ID M7RK68_SALDU, B5F2N5_SALA4, B5R7C3_SALG2, A0A2T9HRQ7_SALET
KEGG ID sea:SeAg_B1113, seg:SG1043
PDB ID -
Pfam domain hit(s)

Domain Pfam ID E-value Aligned region
T6SS_HCP PF05638.14 4.9e-33 8..155
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-172 MPTPCYISITGQTQGNITAGAFTADSVGNIYVQGHEDEMLVQEFLHNVTVPTDPQSGQPSGQRSHKPFIFTVALNKAVPLLYNALASGEMLPKTELHWWRTSVEGKQEHYFTTRLTDSTIVDMKLHMPHCQDPAKREFTQLLEVSLAYRKIEWEHVKSGTSGADDWRAPLEA


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9222 - -


  Protein sequence: 173 a.a.    

>T6CP008719 NC_011274:1134853-1135371 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] [TssD]
MPTPCYISITGQTQGNITAGAFTADSVGNIYVQGHEDEMLVQEFLHNVTVPTDPQSGQPSGQRSHKPFIFTVALNKAVPL
LYNALASGEMLPKTELHWWRTSVEGKQEHYFTTRLTDSTIVDMKLHMPHCQDPAKREFTQLLEVSLAYRKIEWEHVKSGT
SGADDWRAPLEA*

  Nucleotide sequence: 519 bp    

>T6CP008719 NC_011274:1134853-1135371 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] [TssD]
ATGCCAACACCGTGTTACATCTCAATTACGGGGCAAACCCAGGGCAATATCACCGCTGGTGCATTCACCGCAGATTCTGT
CGGCAATATCTACGTGCAGGGTCACGAGGATGAAATGCTGGTACAGGAATTCCTGCATAACGTGACCGTACCCACTGATC
CACAGTCCGGGCAGCCGAGCGGCCAGCGTTCGCACAAGCCGTTCATTTTTACCGTGGCGCTGAACAAAGCCGTACCGCTG
CTGTACAACGCGCTGGCGTCCGGTGAAATGCTGCCGAAAACCGAACTGCACTGGTGGCGTACTTCCGTTGAAGGCAAGCA
GGAGCATTACTTCACCACCCGCCTGACGGACTCAACGATTGTGGATATGAAACTGCATATGCCGCACTGTCAGGACCCGG
CAAAGCGCGAATTCACGCAGTTGCTCGAAGTCTCGCTGGCCTACCGCAAAATCGAGTGGGAACACGTCAAATCCGGCACC
TCTGGCGCGGATGACTGGCGCGCGCCGCTGGAAGCGTAA