Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01301  |
| T6SS type | Type i3 |
| Strain | Burkholderia gladioli strain NGJ1 |
| Replicon (GenBank) | chromosome (LEKY01000074) |
| Location | 55199..85982 |
| Function | anti-bacterial; anti-eukaryotic; effector translocation |
| Comment | Burkholderia gladioli strain NGJ1 utilizes two different type VI secretion systems for antibacterial activity, and T6SS-1-strain was defective in Hcp-1 secretion but proficient in Hcp-2 secretion. On the other hand, T6SS-2-strain was defective in secretion of Hcp-2 but proficient in secretion of Hcp-1 |
| References | [1] Yadav SK, Magotra A, Ghosh S, Krishnan A, Pradhan A, Kumar R, Das J, Sharma M, Jha G. et al (2021) Immunity proteins of dual nuclease T6SS effectors function as transcriptional repressors.. EMBO Rep. 22(6):e51857. [PudMed:33786997] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TagF | TagH | TagJ | TssA | TssB | TssC | TssD | TssE | TssG | TssH | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP016236 | TssB | ACI79_RS29605 | 55199..55720 | - | 522 | 503454535 | - |
| T6CP016237 | TssC | ACI79_RS29610 | 55729..57222 | - | 1494 | 836692010 | - |
| T6CP016238 | TssD | ACI79_RS29615 | 57344..57847 | - | 504 | 738096046 | - |
| T6CP016239 | TagJ | ACI79_RS29620 | 57922..58743 | - | 822 | 836691984 | - |
| T6CP016240 | TssE | ACI79_RS29625 | 58757..59260 | - | 504 | 503454539 | - |
| ACI79_RS29630 | 59267..61156 | - | 1890 | 836691985 | - | ||
| T6CP016242 | TssG | ACI79_RS29635 | 61120..62136 | - | 1017 | 503454541 | - |
| T6CP016243 | TssH | ACI79_RS29640 | 62231..65089 | - | 2859 | 836691986 | - |
| T6CP016244 | TssI | ACI79_RS29660 | 68117..70003 | - | 1887 | 836691990 | - |
| T6CP016245 | TagH | ACI79_RS29670 | 70545..72629 | - | 2085 | 920807630 | - |
| T6CP016246 | TssK | ACI79_RS29675 | 72698..74035 | - | 1338 | 836691991 | - |
| T6CP016247 | TssL | ACI79_RS29680 | 74032..75438 | - | 1407 | 836691992 | - |
| T6CP016248 | TssM | ACI79_RS29685 | 75443..79048 | - | 3606 | 836691993 | - |
| T6CP016249 | TagF | ACI79_RS29690 | 79045..80688 | - | 1644 | 836691994 | - |
| T6CP016250 | TssA | ACI79_RS29710 | 84909..85982 | - | 1074 | 836691997 | - |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01894 |
ACI79_RS12840 (TseTBg1) | Tde | IMU00383 |
Burkholderia gladioli NGJ1 | chromosome (LEKY01000011) | 27037..27744 (-) | 836689521 |
| EFF01895 |
AC179_RS29610 (Hcp-2) | Tde | IMU00385 |
Burkholderia gladioli NGJ1 | chromosome (LEKY01000082) | 22675..23391 (-) | 836692495 |
| EFF01900 |
ACI79_RS22680 (TseTBg3) | Tde | IMU00384 |
Pseudomonas aeruginosa PAO1 | chromosome (LEKY01000067) | 197941..198465 (-) | 836690956 |
| EFF01896 |
AC179_RS29610 (Hcp-2) | - | - | Burkholderia gladioli NGJ1 | chromosome (LEKY01000074) | 57344..57847 (+) | 738096046 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00383 |
ACI79_RS12840 (TsiTBg1) | EFF01894 |
Burkholderia gladioli NGJ1 | chromosome (LEKY01000011) | 27037..27744 (-) | 836689521 |
| IMU00384 |
ACI79_RS22675 (TsiTBg3) | EFF01900 |
Burkholderia gladioli NGJ1 | chromosome (LEKY01000067) | 197212..197877 (-) | 920807205 |
| IMU00385 |
ACI79_RS32200 (TsiTBg2) | EFF01895 |
Burkholderia gladioli NGJ1 | chromosome (LEKY01000082) | 23400..23981 (-) | 920807827 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|