Detailed information of effector


Summary

Effector ID EFF01820 experimental
Effector type Tme
Cognate immunity protein IMU00357 experimental
Related T6SS (Type) T6SS01168 experimental (Type i1)
Strain Vibrio cholerae C6706
Replicon chromosome
Sequence Protein sequence (1086 a.a.); Nucleotide sequence (3258 bp)
Description VasX protein
Reference
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
External database links

Locus tag (Gene) GPY04_RS16385 (VasX)
Coordinates (Strand) 405867..409124 (-)
NCBI ID 445992499
RefSeq NZ_CP046845
Uniprot ID UPI0001BAE095
KEGG ID -
PDB ID -
Pfam domain hit(s)

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Domain
Pfam ID
E-value
Aligned region
No matching records found
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-756MSNPNQAAKTGQTNDAQNPASACPFKQPLIGIIPVRYAFDVYDDQGQALHPLPKADRQWKGQFSIKQRSYTLRQLRDGWLYVYDETAKTLHEYEVVGCKLTKIDWSDDEANKPTHERGSKGESKSCLLYPAQHTLSIGYAHQRWTWRVCEHMRSNTSSRHAVMRKVSLKQFESNGTHPHAHFAQYLEDYVADIGTPAEQDIFKDTCTPSLPVEKSEEAVKGTEFKFVADKAVVSSSDYLQDLPEQNCGLFVALNDPLADVSDLFVTFTTQVAKRTKAIGDETQQHKMQMAELTRTLGRIRLEEKEIPDFVKQDPIRILELERAITEYCATAKLAEIESHHLASEGHSPSGNYALMQQQAEQKLAELKTLYRFEPTSAQMRKWRKKDNSFIDEVRWADLDNFLVEHYTELKGLDEQIKQHYAQFMSAFNQLGLDPLLFGMDNQDEVQQAYLLALTSQFLVVVTQVNHDEKSLEILKKDLSFDSPKNLMALASTGFSLQANQAINNHIQGFSTAFLSTSNPSDMVAFATAIANWDTFTGDERIQEKAWFKRWIEPVQSSFGALQKAVANQAKESWQAVMELLFPYQNQPKGGTPSLLANLRLLLVESLVREEAVLQHNPKYAAELKQFETKLNAILQEMNDALELKPGNVSPKNHQIATAQSAQRKLGQLLSSELPMMLTLKNQAAMNTFQQSVNEKLSALSKNVKTSSASVSQKLGGLGGLLFALNLWNTMTVLENIRYKVAQYPSWNPFKNPALGE
Transmembrane helix757-779AIYATGNTIVVAGAISAGRAWVT
Inside780-859IAEQGLLDRTLKNALNTTKVLGTKDALKTFAKSIALVATVGMIASALETWESWGKFNDSSKTDLERFGYLLKAGATGAQG
Transmembrane helix860-882IIFYIQFFTLLGSGIGGPSIAAI
Outside883-885SAG
Transmembrane helix886-908WMLAGFAVIGIVYLIGVILTNVF
Inside909-1085KRSELEIWLSKSTWGKESAHWPVGKELTELEHLLHRPSLRLSQVTQRKAAQWMDSGSLQWQLELTLPDYLKGQTIGLQITRLPAQPAYYQPQREAVTPILINEQQGKWSIEDNQPVYRITLGGSEKDTVGVCVALPLRWGKELSLKFYASGTRAGELDLQSAEANDIATRNLVVGKG


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.9607--


  Protein sequence: 1086 a.a.    .

>EFF01820 NZ_CP046845:c409124-405867 Type VI Membrane-disrupting Effector (Tme) [Vibrio cholerae C6706]
MSNPNQAAKTGQTNDAQNPASACPFKQPLIGIIPVRYAFDVYDDQGQALHPLPKADRQWKGQFSIKQRSYTLRQLRDGWL
YVYDETAKTLHEYEVVGCKLTKIDWSDDEANKPTHERGSKGESKSCLLYPAQHTLSIGYAHQRWTWRVCEHMRSNTSSRH
AVMRKVSLKQFESNGTHPHAHFAQYLEDYVADIGTPAEQDIFKDTCTPSLPVEKSEEAVKGTEFKFVADKAVVSSSDYLQ
DLPEQNCGLFVALNDPLADVSDLFVTFTTQVAKRTKAIGDETQQHKMQMAELTRTLGRIRLEEKEIPDFVKQDPIRILEL
ERAITEYCATAKLAEIESHHLASEGHSPSGNYALMQQQAEQKLAELKTLYRFEPTSAQMRKWRKKDNSFIDEVRWADLDN
FLVEHYTELKGLDEQIKQHYAQFMSAFNQLGLDPLLFGMDNQDEVQQAYLLALTSQFLVVVTQVNHDEKSLEILKKDLSF
DSPKNLMALASTGFSLQANQAINNHIQGFSTAFLSTSNPSDMVAFATAIANWDTFTGDERIQEKAWFKRWIEPVQSSFGA
LQKAVANQAKESWQAVMELLFPYQNQPKGGTPSLLANLRLLLVESLVREEAVLQHNPKYAAELKQFETKLNAILQEMNDA
LELKPGNVSPKNHQIATAQSAQRKLGQLLSSELPMMLTLKNQAAMNTFQQSVNEKLSALSKNVKTSSASVSQKLGGLGGL
LFALNLWNTMTVLENIRYKVAQYPSWNPFKNPALGEAIYATGNTIVVAGAISAGRAWVTIAEQGLLDRTLKNALNTTKVL
GTKDALKTFAKSIALVATVGMIASALETWESWGKFNDSSKTDLERFGYLLKAGATGAQGIIFYIQFFTLLGSGIGGPSIA
AISAGWMLAGFAVIGIVYLIGVILTNVFKRSELEIWLSKSTWGKESAHWPVGKELTELEHLLHRPSLRLSQVTQRKAAQW
MDSGSLQWQLELTLPDYLKGQTIGLQITRLPAQPAYYQPQREAVTPILINEQQGKWSIEDNQPVYRITLGGSEKDTVGVC
VALPLRWGKELSLKFYASGTRAGELDLQSAEANDIATRNLVVGKG*

  Nucleotide sequence: 3258 bp    .

>EFF01820 NZ_CP046845:c409124-405867 Type VI Membrane-disrupting Effector (Tme) [Vibrio cholerae C6706]
ATGAGTAATCCCAATCAAGCTGCGAAAACAGGACAGACCAATGATGCGCAAAATCCCGCCAGTGCATGTCCTTTTAAACA
GCCGTTAATAGGGATAATTCCTGTTCGTTACGCCTTTGATGTTTATGATGATCAAGGTCAAGCATTACATCCTTTACCCA
AAGCGGATCGACAGTGGAAAGGTCAATTCTCTATCAAGCAGCGCAGTTACACTTTAAGGCAACTGCGTGATGGCTGGCTC
TATGTCTATGATGAAACAGCAAAAACACTGCACGAATATGAAGTCGTTGGCTGCAAGTTGACCAAAATTGATTGGTCTGA
TGATGAGGCAAACAAACCCACTCACGAGCGCGGTTCGAAAGGTGAAAGCAAAAGCTGTTTACTCTATCCCGCCCAGCACA
CGCTCTCTATCGGTTATGCGCATCAACGATGGACGTGGCGAGTGTGTGAGCATATGCGCTCCAATACCAGCAGCCGTCAT
GCTGTGATGCGTAAAGTGAGCCTTAAACAGTTTGAGTCCAATGGTACTCACCCTCATGCACATTTTGCTCAGTATCTTGA
AGACTATGTGGCGGACATCGGGACGCCAGCTGAGCAGGATATTTTTAAAGATACCTGTACCCCTTCATTACCGGTAGAGA
AAAGTGAAGAAGCGGTGAAAGGTACGGAATTCAAATTCGTTGCCGACAAAGCGGTGGTAAGCAGCAGTGATTATTTGCAA
GATTTGCCGGAGCAAAACTGCGGTTTATTTGTGGCGCTGAATGACCCTTTAGCGGATGTGTCAGATTTATTTGTTACTTT
TACTACCCAAGTGGCAAAGCGAACTAAAGCGATTGGTGATGAAACGCAACAGCATAAAATGCAGATGGCAGAGCTGACAC
GCACATTAGGCCGAATTCGTCTTGAAGAAAAAGAAATTCCCGATTTTGTAAAACAAGATCCGATCCGTATTTTAGAGCTA
GAAAGAGCCATTACTGAATATTGTGCTACGGCAAAATTGGCCGAAATCGAATCTCATCATTTAGCCAGTGAAGGGCATTC
CCCATCGGGAAACTATGCCTTGATGCAGCAGCAAGCGGAGCAGAAACTGGCGGAATTGAAAACACTCTATCGCTTTGAAC
CCACCAGTGCTCAGATGCGCAAGTGGCGCAAAAAAGACAACAGCTTTATTGATGAAGTGCGTTGGGCGGATTTAGATAAC
TTTTTGGTGGAGCATTACACCGAGCTCAAAGGATTGGATGAACAGATTAAACAACACTATGCGCAGTTTATGTCTGCCTT
CAACCAGCTCGGCCTTGACCCGCTTCTGTTTGGTATGGATAACCAAGATGAGGTTCAGCAAGCGTATTTGTTAGCATTAA
CTAGCCAATTTTTAGTGGTGGTTACGCAAGTCAATCATGATGAAAAATCGCTTGAGATCCTAAAAAAAGATCTCAGTTTT
GATTCACCGAAAAACCTCATGGCCCTCGCGTCAACAGGCTTTTCCCTGCAGGCAAATCAAGCCATTAACAACCATATCCA
AGGGTTTAGCACCGCTTTTCTCTCTACAAGTAATCCTAGTGATATGGTGGCGTTTGCGACCGCAATCGCTAACTGGGATA
CGTTCACGGGGGATGAACGTATTCAGGAGAAAGCATGGTTTAAGAGATGGATTGAACCCGTTCAATCGAGTTTTGGTGCA
CTGCAAAAAGCGGTCGCCAATCAAGCCAAAGAGAGTTGGCAAGCGGTGATGGAGTTGCTGTTTCCTTATCAGAATCAGCC
CAAAGGAGGGACGCCCAGTTTGTTGGCTAACCTTCGTTTACTGTTGGTGGAAAGCCTAGTTCGAGAAGAGGCGGTGCTGC
AACATAACCCCAAGTATGCGGCTGAGCTTAAGCAATTTGAGACTAAGCTGAATGCCATTTTGCAAGAGATGAATGATGCT
CTGGAACTCAAACCCGGTAATGTGAGCCCGAAAAACCATCAAATTGCGACCGCGCAATCCGCACAACGTAAGCTAGGGCA
ATTACTCAGTAGTGAGCTGCCGATGATGCTGACGCTCAAAAACCAAGCTGCGATGAACACTTTTCAGCAGTCGGTAAATG
AGAAACTGAGCGCGCTATCGAAAAACGTCAAAACCAGTAGCGCGTCGGTGAGTCAGAAACTGGGTGGATTAGGGGGCTTG
CTGTTTGCGTTGAACCTATGGAATACCATGACGGTTTTGGAGAATATCCGCTATAAGGTCGCACAATACCCCAGTTGGAA
TCCTTTTAAGAACCCGGCGTTGGGCGAAGCCATTTATGCCACTGGCAACACTATTGTAGTCGCCGGTGCCATTAGTGCTG
GGCGAGCTTGGGTGACGATTGCTGAGCAAGGGTTGTTAGATCGTACACTGAAAAACGCCTTAAATACCACGAAAGTTTTG
GGCACAAAAGATGCCCTAAAAACCTTTGCTAAATCGATCGCCTTGGTGGCTACCGTGGGCATGATTGCCAGCGCATTAGA
AACATGGGAAAGCTGGGGTAAGTTTAATGACAGCAGTAAAACCGATCTTGAACGCTTCGGTTATTTGTTAAAAGCTGGAG
CAACGGGAGCACAGGGAATTATTTTTTATATTCAGTTTTTCACACTCTTAGGTAGTGGAATTGGTGGACCCTCCATAGCT
GCGATTTCTGCAGGTTGGATGCTCGCCGGTTTTGCTGTGATTGGTATTGTCTATTTGATCGGGGTGATTTTGACCAATGT
GTTTAAACGCTCAGAGTTAGAAATTTGGTTATCAAAATCGACGTGGGGGAAAGAGAGTGCTCATTGGCCAGTGGGCAAAG
AATTGACCGAGTTAGAGCACCTTCTCCATCGTCCGAGTCTTCGGTTGAGTCAAGTTACGCAACGTAAAGCAGCGCAATGG
ATGGATTCAGGTTCTTTACAATGGCAGTTGGAACTCACGTTACCCGATTATCTTAAGGGGCAGACGATAGGCTTACAAAT
CACCCGTTTGCCAGCGCAGCCGGCATATTATCAACCGCAAAGGGAGGCGGTAACACCAATACTCATCAATGAACAACAGG
GCAAATGGAGTATTGAAGATAATCAGCCAGTGTATCGTATTACACTGGGTGGCAGTGAGAAGGATACTGTCGGAGTTTGC
GTTGCACTGCCCCTGCGTTGGGGCAAGGAGCTGAGCCTCAAATTCTATGCCAGTGGAACTCGCGCGGGGGAATTGGATTT
ACAATCTGCAGAGGCGAATGATATTGCCACAAGAAATCTCGTTGTAGGAAAAGGTTAA