Detailed information of regulator

Summary

Regulator ID	REG0341
Regulator type	protein
Regulatory pathway (from literatures)	TCS-RR
KEGG pathway (determined by BlastKOALA)	Two-component system (map02020); Biofilm formation - Escherichia coli (map02026)
Related T6SS	T6SS01214 (Type Unknown)
Strain	Klebsiella pneumoniae strain Kp52.145
Replicon	chromosome
Sequence	Protein sequence (217 a.a.); Nucleotide sequence (651 bp)
Description	The expression of tssB::lucFF was significantly higher in the h-ns, mgrB and rcsB mutant backgrounds than in the wild-type one and co-incubation of the h-ns, mgrB and rcsB mutants with E. coli in LB resulted in a significant reduction in E. coli survival.
Reference	[1] Storey D, McNally A, Åstrand M, et al. Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent. PLoS Pathog. 2020 Mar 19;16(3):e1007969. doi: 10.1371/journal.ppat.1007969. eCollection 2020 Mar. PMID: 32191774

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External database links

Locus tag (Gene)	BN49_RS21260 (rcsB)
Coordinates (Strand)	4066268..4066918 (+)
NCBI ID	489002368
RefSeq	NZ_FO834906
Uniprot ID	A0A0H3GVM1_KLEPH, J2LQ26_KLEPN, V0ARH3_KLEPN, A0A0E1CB82_KLEPN, W8UEU3_KLEPN, A0A2N4VH32_9ENTR, A6TBT4_KLEP7, A0A1Y6GE49_RAOOR, Q8GM84_KLEPN, A0A1Y0PX35_KLEPN, R4YCG2_KLEPR
KEGG ID	kpx:PMK1_00136, kpnu:LI86_07890, kpm:KPHS_37040, kpt:VK055_4883, kpy:KPNIH31_17640, kps:KPNJ2_01679, kpr:KPR_2075, kpn:KPN_02638, kpv:KPNIH29_18485, kpw:KPNIH30_18710, kpb:FH42_09310, kpa:KPNJ1_01711, kpnk:BN49_3854, kpg:KPNIH32_19040
KEGG pathway (determined by BlastKOALA)	map02020; map02026
PDB ID	-

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  Target

Target	Regulation (↓/↑)	Target sequence
phoPQ	↑	-

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Pfam domain hit(s) of regulator

Domain	Pfam ID	E-value	Aligned region
Response_reg	PF00072.26	1.2e-24	6..120
GerE	PF00196.21	3.4e-12	151..201

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Transmembrane helices

• Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-216	MNTMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPDLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISASGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVSLSATDKE

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Signal peptides

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9973	-	-

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  Protein sequence of regulator: 217 a.a.    .Download


  Nucleotide sequence of regulator: 651 bp    .Download