Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01214  |
| T6SS type | Type Unknown |
| Strain | Klebsiella pneumoniae strain Kp52.145 |
| Replicon (RefSeq) | chromosome (NZ_FO834906) |
| Location | 950009..972445 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Kp52145 T6SS-dependent intra and inter species bacterial competition is dependent on VgrG4 and GST-VgrG4 caused a strong inhibition of yeast growth show VgrG4 is a bona fide T6SS toxin and that the C-terminal extension containing the DUF2345 domain is sufficient for the anti-bacterial and anti-eukaryotic effect |
| References | [1] Storey D, McNally A, |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssC | TssE | TssF | TssG | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BN49_RS05915 | 945115..945792 | + | 678 | WP_004143925.1 | energy-coupling factor ABC transporter transmembrane protein | ||
| BN49_RS05920 | 945801..946625 | + | 825 | WP_002915614.1 | energy-coupling factor ABC transporter ATP-binding protein | ||
| BN49_RS05925 | 946622..948145 | + | 1524 | WP_046042498.1 | cobyric acid synthase | ||
| BN49_RS05930 (cobU) | 948139..948684 | + | 546 | WP_004890028.1 | bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase | ||
| BN49_RS05935 (cobT) | 948728..949783 | + | 1056 | WP_016529969.1 | nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | ||
| BN49_RS30880 | 949803..949940 | + | 138 | WP_156720420.1 | hypothetical protein | ||
| T6CP015358 | TssE | BN49_RS05940 (tssE) | 950009..950434 | - | 426 | WP_004181152.1 | type VI secretion system baseplate subunit TssE |
| T6CP015359 | TssJ | BN49_RS05945 (tssJ) | 950438..950716 | - | 279 | pseudogene | type VI secretion system lipoprotein TssJ |
| BN49_RS05950 | 950730..951962 | - | 1233 | pseudogene | IS3 family transposase | ||
| BN49_RS05960 | 952054..952311 | - | 258 | pseudogene | type VI secretion lipoprotein TssJ | ||
| T6CP015360 | TssG | BN49_RS05965 (tssG) | 952292..953374 | - | 1083 | WP_004181150.1 | type VI secretion system baseplate subunit TssG |
| T6CP015361 | TssF | BN49_RS05970 (tssF) | 953338..955098 | - | 1761 | WP_016531437.1 | type VI secretion system baseplate subunit TssF |
| BN49_RS05975 | 955255..955851 | - | 597 | WP_077254440.1 | hypothetical protein | ||
| BN49_RS29920 | 955863..956621 | - | 759 | WP_101999050.1 | hypothetical protein | ||
| BN49_RS05990 | 957144..957404 | - | 261 | WP_009485635.1 | PAAR domain-containing protein | ||
| T6CP015362 | TssA | BN49_RS05995 | 957477..957896 | - | 420 | WP_162869795.1 | ImpA domain protein |
| T6CP015363 | TssM | BN49_RS06000 | 957862..961227 | - | 3366 | WP_046042502.1 | type VI secretion protein VasK |
| BN49_RS06005 | 961224..962363 | - | 1140 | WP_046042504.1 | hypothetical protein | ||
| BN49_RS06010 | 962669..963040 | - | 372 | WP_016530473.1 | hypothetical protein | ||
| BN49_RS06015 | 963149..964222 | - | 1074 | WP_009485630.1 | hypothetical protein | ||
| BN49_RS06020 | 964262..965713 | - | 1452 | WP_032104126.1 | hypothetical protein | ||
| T6CP015364 | TssI | BN49_RS06025 (vgrG) | 965716..968271 | - | 2556 | WP_046042506.1 | type VI secretion system tip protein VgrG |
| BN49_RS06030 | 968487..970181 | - | 1695 | WP_170925904.1 | OmpA family protein | ||
| T6CP015365 | TssL | BN49_RS06035 | 970193..970858 | - | 666 | WP_004181140.1 | type VI secretion system protein TssL, short form |
| T6CP015366 | TssK | BN49_RS06040 (tssK) | 970855..972195 | - | 1341 | WP_004142901.1 | type VI secretion system baseplate subunit TssK |
| T6CP015367 | TssC | BN49_RS06045 | 972197..972445 | - | 249 | WP_004142899.1 | hypothetical protein |
| BN49_RS06060 (mltA) | 974088..975185 | + | 1098 | WP_046042519.1 | murein transglycosylase A | ||
| BN49_RS06065 (tcdA) | 975273..976094 | + | 822 | WP_016530752.1 | tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA | ||
| BN49_RS06070 (csdE) | 976137..976568 | - | 432 | WP_004142894.1 | cysteine desulfurase sulfur acceptor subunit CsdE |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed. Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|