Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS17505  |
| T6SS type | Type i3 |
| Strain | Serratia marcescens strain KZ11 |
| Replicon (RefSeq) | chromosome (NZ_PQGJ01000003) |
| Location | 580953..617916 |
| Function | anti-bacterial |
| Comment | Strains lacking structural components of T6SS-2 had reduced ability to antagonize E. coli K-12 during in vitro competition assays, with deletion of tssE2 having a greater effect |
| References | [1] Steele MI, Motta EVS, Gattu T, Martinez D, Moran NA. et al (2021) The Gut Microbiota Protects Bees from Invasion by a Bacterial Pathogen.. Microbiol Spectr. 9(2):e0039421. [PudMed:34523998] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | PpkA | PppA | TagF | TagH | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| C3R39_RS13860 | 576593..577888 | - | 1296 | WP_180995758.1 | MFS transporter | ||
| C3R39_RS13870 | 578099..579136 | - | 1038 | WP_033632715.1 | LacI family transcriptional regulator | ||
| C3R39_RS13875 (kynA) | 579432..580274 | + | 843 | WP_015378298.1 | tryptophan 2,3-dioxygenase | ||
| C3R39_RS13880 (sbmC) | 580297..580764 | + | 468 | WP_048324050.1 | DNA gyrase inhibitor SbmC | ||
| T6CP259553 | TssI | C3R39_RS13885 (vgrG) | 580953..582881 | - | 1929 | WP_103687224.1 | type VI secretion system tip protein VgrG |
| T6CP259554 | PpkA | C3R39_RS13890 | 583024..584469 | - | 1446 | WP_103687225.1 | serine/threonine protein kinase |
| T6CP259555 | TssH | C3R39_RS13895 (tssH) | 584519..587173 | - | 2655 | WP_103687226.1 | type VI secretion system ATPase TssH |
| T6CP259556 | TssG | C3R39_RS13900 (tssG) | 587230..588300 | - | 1071 | WP_103687227.1 | type VI secretion system baseplate subunit TssG |
| T6CP259557 | TssF | C3R39_RS13905 (tssF) | 588297..590183 | - | 1887 | WP_089184749.1 | type VI secretion system baseplate subunit TssF |
| T6CP259558 | TssE | C3R39_RS13910 | 590188..590763 | - | 576 | WP_004934985.1 | GPW/gp25 family protein |
| T6CP259559 | TagJ | C3R39_RS13915 | 590766..591569 | - | 804 | WP_048324037.1 | protein of avirulence locus ImpE |
| C3R39_RS13920 | 591603..592589 | - | 987 | WP_049278139.1 | hypothetical protein | ||
| T6CP259560 | PppA | C3R39_RS13925 | 592618..593391 | - | 774 | WP_004934976.1 | protein phosphatase 2C domain-containing protein |
| T6CP259561 | TagH | C3R39_RS13930 (tagH) | 593391..595118 | - | 1728 | WP_103687228.1 | type VI secretion system-associated FHA domain protein TagH |
| C3R39_RS13935 | 595288..595650 | - | 363 | WP_048324030.1 | hypothetical protein | ||
| C3R39_RS13940 | 595843..596202 | - | 360 | WP_072062316.1 | hypothetical protein | ||
| C3R39_RS13945 | 596248..596610 | - | 363 | WP_080347692.1 | type VI secretion protein | ||
| C3R39_RS13950 | 596614..597072 | - | 459 | WP_016927257.1 | type VI secretion system amidase immunity protein Tai4 | ||
| C3R39_RS13955 | 597069..597572 | - | 504 | WP_071525932.1 | type VI secretion system amidase effector protein Tae4 | ||
| T6CP259562 | TssD | C3R39_RS13960 | 597624..598106 | - | 483 | WP_004934962.1 | type VI secretion system tube protein Hcp |
| T6CP259563 | TssC | C3R39_RS13965 (tssC) | 598411..599916 | - | 1506 | WP_004934958.1 | type VI secretion system contractile sheath large subunit |
| T6CP259564 | TssB | C3R39_RS13970 (tssB) | 599920..600456 | - | 537 | WP_015378282.1 | type VI secretion system contractile sheath small subunit |
| T6CP259565 | TssA | C3R39_RS13975 (tssA) | 600579..601610 | - | 1032 | WP_103687229.1 | type VI secretion system protein TssA |
| T6CP259566 | TagF | C3R39_RS13980 (tagF) | 601634..602353 | - | 720 | WP_004934950.1 | type VI secretion system-associated protein TagF |
| T6CP259567 | TssM | C3R39_RS13985 (tssM) | 602372..606007 | - | 3636 | WP_103687230.1 | type VI secretion system membrane subunit TssM |
| T6CP259568 | TssL | C3R39_RS13990 | 606007..607209 | - | 1203 | WP_004934945.1 | DotU family type VI secretion system protein |
| T6CP259569 | TssK | C3R39_RS13995 (tssK) | 607231..608577 | - | 1347 | WP_049278152.1 | type VI secretion system baseplate subunit TssK |
| T6CP259570 | TssJ | C3R39_RS14000 (tssJ) | 608618..609148 | - | 531 | WP_042705419.1 | type VI secretion system lipoprotein TssJ |
| C3R39_RS14005 | 609178..609678 | - | 501 | WP_033632731.1 | hypothetical protein | ||
| T6CP259571 | PAAR | C3R39_RS14010 | 609727..610119 | - | 393 | WP_004934933.1 | DUF4150 domain-containing protein |
| C3R39_RS14015 | 610136..610771 | - | 636 | WP_103687231.1 | DUF3540 domain-containing protein | ||
| C3R39_RS14020 | 610802..611869 | - | 1068 | WP_048324022.1 | pentapeptide repeat-containing protein | ||
| C3R39_RS14025 | 611866..614418 | - | 2553 | WP_049279590.1 | DUF2169 domain-containing protein | ||
| C3R39_RS14030 | 614590..615090 | - | 501 | WP_015378272.1 | hypothetical protein | ||
| C3R39_RS14035 | 615177..615566 | - | 390 | WP_016927272.1 | DUF3592 domain-containing protein | ||
| T6CP259572 | TssI | C3R39_RS14040 (vgrG) | 615577..617916 | - | 2340 | WP_048324018.1 | type VI secretion system tip protein VgrG |
| C3R39_RS14045 | 618429..619361 | - | 933 | WP_103687232.1 | LysR family transcriptional regulator | ||
| C3R39_RS14050 (pcp) | 619459..620106 | + | 648 | WP_103687266.1 | pyroglutamyl-peptidase I | ||
| C3R39_RS14055 | 620141..621172 | - | 1032 | WP_103687233.1 | NADP-dependent oxidoreductase | ||
| C3R39_RS14060 (uspC) | 621257..621676 | - | 420 | WP_016927278.1 | universal stress protein UspC | ||
| C3R39_RS14065 (ydgT) | 621874..622089 | - | 216 | WP_004934895.1 | transcription modulator YdgT |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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