Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS17505 experimental
T6SS type Type i3
Strain Serratia marcescens strain KZ11
Replicon (RefSeq) chromosome (NZ_PQGJ01000003)
Location 580953..617916
Function anti-bacterial
Comment Strains lacking structural components of T6SS-2 had reduced ability to antagonize E. coli K-12 during in vitro competition assays, with deletion of tssE2 having a greater effect
References
[1] Steele MI, Motta EVS, Gattu T, Martinez D, Moran NA. et al (2021) The Gut Microbiota Protects Bees from Invasion by a Bacterial Pathogen.. Microbiol Spectr. 9(2):e0039421. [PudMed:34523998]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentPAARPpkAPppATagFTagHTagJTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number1111111111111121111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
C3R39_RS13860 576593..577888 - 1296 WP_180995758.1 MFS transporter
C3R39_RS13870 578099..579136 - 1038 WP_033632715.1 LacI family transcriptional regulator
C3R39_RS13875 (kynA) 579432..580274 + 843 WP_015378298.1 tryptophan 2,3-dioxygenase
C3R39_RS13880 (sbmC) 580297..580764 + 468 WP_048324050.1 DNA gyrase inhibitor SbmC
T6CP259553 TssI C3R39_RS13885 (vgrG) 580953..582881 - 1929 WP_103687224.1 type VI secretion system tip protein VgrG
T6CP259554 PpkA C3R39_RS13890 583024..584469 - 1446 WP_103687225.1 serine/threonine protein kinase
T6CP259555 TssH C3R39_RS13895 (tssH) 584519..587173 - 2655 WP_103687226.1 type VI secretion system ATPase TssH
T6CP259556 TssG C3R39_RS13900 (tssG) 587230..588300 - 1071 WP_103687227.1 type VI secretion system baseplate subunit TssG
T6CP259557 TssF C3R39_RS13905 (tssF) 588297..590183 - 1887 WP_089184749.1 type VI secretion system baseplate subunit TssF
T6CP259558 TssE C3R39_RS13910 590188..590763 - 576 WP_004934985.1 GPW/gp25 family protein
T6CP259559 TagJ C3R39_RS13915 590766..591569 - 804 WP_048324037.1 protein of avirulence locus ImpE
C3R39_RS13920 591603..592589 - 987 WP_049278139.1 hypothetical protein
T6CP259560 PppA C3R39_RS13925 592618..593391 - 774 WP_004934976.1 protein phosphatase 2C domain-containing protein
T6CP259561 TagH C3R39_RS13930 (tagH) 593391..595118 - 1728 WP_103687228.1 type VI secretion system-associated FHA domain protein TagH
C3R39_RS13935 595288..595650 - 363 WP_048324030.1 hypothetical protein
C3R39_RS13940 595843..596202 - 360 WP_072062316.1 hypothetical protein
C3R39_RS13945 596248..596610 - 363 WP_080347692.1 type VI secretion protein
C3R39_RS13950 596614..597072 - 459 WP_016927257.1 type VI secretion system amidase immunity protein Tai4
C3R39_RS13955 597069..597572 - 504 WP_071525932.1 type VI secretion system amidase effector protein Tae4
T6CP259562 TssD C3R39_RS13960 597624..598106 - 483 WP_004934962.1 type VI secretion system tube protein Hcp
T6CP259563 TssC C3R39_RS13965 (tssC) 598411..599916 - 1506 WP_004934958.1 type VI secretion system contractile sheath large subunit
T6CP259564 TssB C3R39_RS13970 (tssB) 599920..600456 - 537 WP_015378282.1 type VI secretion system contractile sheath small subunit
T6CP259565 TssA C3R39_RS13975 (tssA) 600579..601610 - 1032 WP_103687229.1 type VI secretion system protein TssA
T6CP259566 TagF C3R39_RS13980 (tagF) 601634..602353 - 720 WP_004934950.1 type VI secretion system-associated protein TagF
T6CP259567 TssM C3R39_RS13985 (tssM) 602372..606007 - 3636 WP_103687230.1 type VI secretion system membrane subunit TssM
T6CP259568 TssL C3R39_RS13990 606007..607209 - 1203 WP_004934945.1 DotU family type VI secretion system protein
T6CP259569 TssK C3R39_RS13995 (tssK) 607231..608577 - 1347 WP_049278152.1 type VI secretion system baseplate subunit TssK
T6CP259570 TssJ C3R39_RS14000 (tssJ) 608618..609148 - 531 WP_042705419.1 type VI secretion system lipoprotein TssJ
C3R39_RS14005 609178..609678 - 501 WP_033632731.1 hypothetical protein
T6CP259571 PAAR C3R39_RS14010 609727..610119 - 393 WP_004934933.1 DUF4150 domain-containing protein
C3R39_RS14015 610136..610771 - 636 WP_103687231.1 DUF3540 domain-containing protein
C3R39_RS14020 610802..611869 - 1068 WP_048324022.1 pentapeptide repeat-containing protein
C3R39_RS14025 611866..614418 - 2553 WP_049279590.1 DUF2169 domain-containing protein
C3R39_RS14030 614590..615090 - 501 WP_015378272.1 hypothetical protein
C3R39_RS14035 615177..615566 - 390 WP_016927272.1 DUF3592 domain-containing protein
T6CP259572 TssI C3R39_RS14040 (vgrG) 615577..617916 - 2340 WP_048324018.1 type VI secretion system tip protein VgrG
C3R39_RS14045 618429..619361 - 933 WP_103687232.1 LysR family transcriptional regulator
C3R39_RS14050 (pcp) 619459..620106 + 648 WP_103687266.1 pyroglutamyl-peptidase I
C3R39_RS14055 620141..621172 - 1032 WP_103687233.1 NADP-dependent oxidoreductase
C3R39_RS14060 (uspC) 621257..621676 - 420 WP_016927278.1 universal stress protein UspC
C3R39_RS14065 (ydgT) 621874..622089 - 216 WP_004934895.1 transcription modulator YdgT
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector