Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00050  |
| T6SS type | Type i1 |
| Strain | Photorhabdus laumondii subsp. laumondii TTO1 |
| Replicon (RefSeq) | chromosome (NC_005126) |
| Location | 372357..415137 |
| Function | anti-bacterial |
| Comment | The ART-HYD1 toxin domain of Rhs is an antibacterial toxin delivered by the type VI secretion system. |
| References | [1] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] [2] Jur |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PLU_RS01690 | 368554..369261 | - | 708 | WP_011144738.1 | hypothetical protein | ||
| PLU_RS24845 | 369568..369969 | - | 402 | WP_058588885.1 | hypothetical protein | ||
| PLU_RS01695 | 370266..370646 | - | 381 | WP_011144740.1 | SMI1/KNR4 family protein | ||
| PLU_RS26320 | 370668..370968 | - | 301 | pseudogene | hypothetical protein | ||
| PLU_RS01700 | 370937..371134 | + | 198 | WP_011144742.1 | hypothetical protein | ||
| PLU_RS01705 | 371238..371789 | - | 552 | WP_011144743.1 | hypothetical protein | ||
| PLU_RS01710 | 372357..372677 | - | 321 | WP_011144744.1 | hypothetical protein | ||
| PLU_RS01715 | 373064..377092 | - | 4029 | pseudogene | PAAR domain-containing protein | ||
| PLU_RS01720 | 377114..377533 | - | 420 | WP_011144746.1 | DUF1795 domain-containing protein | ||
| T6CP000426 | TssI | PLU_RS01725 | 377581..379476 | - | 1896 | WP_011144747.1 | type VI secretion system tip protein VgrG |
| PLU_RS01730 | 379498..380166 | - | 669 | pseudogene | hypothetical protein | ||
| PLU_RS01735 | 380265..381647 | + | 1383 | WP_011144727.1 | IS4-like element ISPlu9 family transposase | ||
| PLU_RS01740 | 381658..382338 | - | 681 | pseudogene | ImpA family type VI secretion system protein | ||
| T6CP000427 | TssM | PLU_RS01745 (tssM) | 382431..385976 | - | 3546 | WP_011144748.1 | type VI secretion system membrane subunit TssM |
| T6CP009438 | TssA | PLU_RS01750 (tssA) | 385973..387406 | - | 1434 | WP_011144749.1 | type VI secretion system protein TssA |
| PLU_RS01755 (tagO) | 387412..388059 | - | 648 | WP_011144750.1 | type VI secretion system-associated protein TagO | ||
| PLU_RS01760 | 388056..388856 | - | 801 | WP_011144751.1 | Fis family transcriptional regulator | ||
| T6CP000428 | TssH | PLU_RS01765 (tssH) | 388853..391498 | - | 2646 | WP_011144752.1 | type VI secretion system ATPase TssH |
| T6CP000429 | TssL | PLU_RS01770 (icmH) | 391509..392279 | - | 771 | WP_011144753.1 | type IVB secretion system protein IcmH/DotU |
| T6CP000430 | TssK | PLU_RS01775 (tssK) | 392279..393631 | - | 1353 | WP_011144754.1 | type VI secretion system baseplate subunit TssK |
| T6CP000431 | TssJ | PLU_RS01780 (tssJ) | 393634..394200 | - | 567 | WP_011144755.1 | type VI secretion system lipoprotein TssJ |
| T6CP011440 | FHA | PLU_RS01785 (tagH) | 394200..395486 | - | 1287 | WP_011144756.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP000432 | TssG | PLU_RS01790 (tssG) | 395492..396544 | - | 1053 | WP_041379883.1 | type VI secretion system baseplate subunit TssG |
| T6CP000433 | TssF | PLU_RS01795 (tssF) | 396508..398355 | - | 1848 | WP_011144758.1 | type VI secretion system baseplate subunit TssF |
| T6CP008432 | TssE | PLU_RS01800 (tssE) | 398357..398797 | - | 441 | WP_011144759.1 | type VI secretion system baseplate subunit TssE |
| T6CP000434 | TssC | PLU_RS01805 (tssC) | 398804..400282 | - | 1479 | WP_011144760.1 | type VI secretion system contractile sheath large subunit |
| T6CP000435 | TssB | PLU_RS01810 (tssB) | 400306..400803 | - | 498 | WP_011144761.1 | type VI secretion system contractile sheath small subunit |
| T6CP008433 | TssD | PLU_RS01815 | 401704..402222 | + | 519 | WP_011144762.1 | Hcp family type VI secretion system effector |
| PLU_RS01820 | 402861..403703 | + | 843 | WP_011144763.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | ||
| PLU_RS01825 (gorA) | 403814..405169 | + | 1356 | WP_109791286.1 | glutathione-disulfide reductase | ||
| PLU_RS01830 | 405435..406523 | + | 1089 | WP_011144765.1 | DUF4297 domain-containing protein | ||
| PLU_RS01835 | 406520..408172 | + | 1653 | WP_011144766.1 | hypothetical protein | ||
| PLU_RS01840 (mobB) | 408253..408771 | - | 519 | WP_011144767.1 | molybdopterin-guanine dinucleotide biosynthesis protein B | ||
| PLU_RS01845 (mobA) | 408768..409358 | - | 591 | WP_041379884.1 | molybdenum cofactor guanylyltransferase MobA | ||
| PLU_RS01850 | 409576..410568 | + | 993 | WP_011144769.1 | serine/threonine protein kinase | ||
| PLU_RS01855 (dsbA) | 410589..411212 | + | 624 | WP_011144770.1 | thiol:disulfide interchange protein DsbA | ||
| PLU_RS01860 | 411368..412531 | - | 1164 | WP_041379885.1 | putative DNA binding domain-containing protein | ||
| PLU_RS01865 | 412510..415137 | - | 2628 | WP_011144772.1 | histidinol-phosphatase | ||
| PLU_RS01870 | 415165..415404 | - | 240 | WP_011144773.1 | hypothetical protein | ||
| PLU_RS01875 | 415530..416543 | + | 1014 | WP_011144774.1 | IS630-like element ISPlu10 family transposase | ||
| PLU_RS01880 (polA) | 417018..419807 | + | 2790 | WP_011144775.1 | DNA polymerase I |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF18620 |
Plu0353 (Tre23) | Tre | IMU17296 |
Photorhabdus laumondii subsp. laumondii TTO1 | chromosome (NC_005126) | 373064..377092 (-) | CAE12648.1 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU17296 |
Plu0352 (Tri23) | EFF18620 |
Photorhabdus laumondii subsp. laumondii TTO1 | chromosome (NC_005126) | 377114..377533 (-) | WP_011144746.1 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP26818 |
Plu0354 (EagR) | adaptor | Photorhabdus laumondii subsp. laumondii TTO1 | chromosome (NC_005126) | 372357..372677 (-) | WP_011144744.1 | - | Plu0353 (Tre23) |